Results 71 to 80 of about 1,038 (93)

Molecular mechanisms of α-conotoxin [S9K]TxID selectively targeting the rat α3β4 nicotinic acetylcholine receptor

International Journal of Biological Macromolecules
α3β4 nicotinic acetylcholine receptor (nAChR) is a potential therapeutic target for the treatment of drug dependence and addiction, lung cancer, overeating and obesity and other disorders.
Jinpeng Yu, Shuqi Zhao, Jianying Dong
exaly   +2 more sources

Enhancing Stability and Albumin Binding Efficiency of α-Conotoxin GI through Fatty Acid Modification.

Biochemistry, 2023
α-Conotoxin GI is a competitive blocker of muscle-type acetylcholine receptors and holds the potential for being developed as a molecular probe or a lead compound for drug discovery.
Panpan Qi, Q. He, Junjie Zhang, Yuanyuan Lian, Ting Xie, Jianying Dong, Dongting Zhangsun, Yong Wu, S. Luo   +8 more
semanticscholar   +1 more source

Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3β2 and α3β4 Nicotinic Receptors via an Electrostatic Mechanism.

ACS Chemical Neuroscience, 2023
Understanding the determinants of α-conotoxin (α-CTX) selectivity for different nicotinic acetylcholine receptor (nAChR) subtypes is a prerequisite for the design of tool compounds to study nAChRs.
Yves Haufe, Veeresh Kuruva, Ziyana Samanani, Gonxhe Lokaj, Guy Kamnesky, PranavKumar Shadamarshan, Rezvan Shahoei, Dana Katz, Jared M. Sampson, Michael Pusch, A. Brik, A. Nicke, Abba E. Leffler   +12 more
semanticscholar   +1 more source

Dissecting oxidative folding of conotoxins using 3D structures of cysteine mutants predicted by AlphaFold 3: A case study of α-conotoxin RgIA, χ-conotoxin CMrVIA and ω-conotoxin MVIIA-Gly.

Toxicon
The ability of AlphaFold 3 to accurately predict the 3D structure of polypeptides has been explored to investigate the oxidative folding steps of conotoxins.
K. Radhakrishna, Patil Kanchan Rajshekhar, R. Arshitha, K. Patil, Shweta Dhannura, K. H. Gowd   +5 more
semanticscholar   +1 more source

Variable peptide processing of a Conus (Asprella) neocostatus α-conotoxin generates bioactive toxiforms that are potent against distinct nicotinic acetylcholine receptor subtypes.

Biochemical Pharmacology
Conusvenoms are composed of peptides that are commonly post-translationally modified, increasing their chemical diversity beyond what is encoded in the genome and enhancing their potency and selectivity. This study describes how PTMs alter an α-conotoxin'
C. M. Ramones, Ryoichi Taguchi, Ella Mae E Gamba, Abe Ernest Johann E. Isagan, M. Watkins, Meljune Chicote, Michael C Velarde, A. J. L. Villaraza, Eizadora T Yu, Baldomero M Olivera, G. Concepcion, A. Lluisma   +11 more
semanticscholar   +1 more source

The α3β4 nAChR tissue distribution identified by fluorescent α-conotoxin [D11A]LvIA.

International Journal of Biological Macromolecules
α3β4, a vital subtype of neuronal nicotinic acetylcholine receptors (nAChRs), is widely distributed in the brain, ganglia, and adrenal glands, associated with addiction and neurological diseases.
Chenxing Xu, Nan Wang, Tao Ma, Shengrong Pei, Meiting Wang, Jinpeng Yu, Dongting Zhangsun, Xiaopeng Zhu, S. Luo   +8 more
semanticscholar   +1 more source

α-Conotoxin LvID, an antagonist of α7 nicotinic acetylcholine receptor, mitigates Alzheimer-associated phenotypes by inhibiting Aβ deposition and reactive astrogliosis.

International Journal of Biological Macromolecules
Alzheimer's disease (AD) is the most common form of dementia in older adults. Neuritic plaques and reactive astrogliosis are neuropathological hallmarks of AD.
Song Yue, Haonan Xing, Xiaoxue Du, Yufei Wang, Runtian Qin, Jinsheng He, Jinpeng Yu, Dongting Zhangsun, D. Craik, J. M. McIntosh, Yili Wu, Xiaopeng Zhu, Sulan Luo   +12 more
semanticscholar   +1 more source

Identification of key determinants in α subunit for α-conotoxin [D1G, ΔQ14]LvIC selectively targeting rat α6/α3β4 nicotinic acetylcholine receptor.

Neuropharmacology
nAChRs containing α6 subunit (α6* nAChRs) are identified as being involved in Parkinson's disease, dyskinesia, drug addiction, and other disorders. Among these, α6β4 nAChR is recognized as a highly promising target for the development of non-opioid ...
Baixue An, Zepei Tang, Ke Hu, Pengcheng Wei, Dongting Zhangsun, Xiaopeng Zhu, Jinpeng Yu, Sulan Luo   +7 more
semanticscholar   +1 more source

Site-specific post-translational modifications regulate the binding affinity of Conus amadis α-conotoxin Am2005 to Ac-AChBP.

Journal of Biomolecular Structure and Dynamics
Post-translational modifications (PTMs) play a pivotal role in diversifying the structure and function of peptide toxins from marine cone snails, which have proven applications in the treatment of neuropathic pain.
Shweta Dhannura, Marimuthu Vijayasarathy, K. Patil, B. Manjunath, Rajesh Sonti, Prasanna D. Revanasiddappa, K. H. Gowd   +6 more
semanticscholar   +1 more source

α-conotoxin TxID and its mutants targeting α3β4 nAChR subtype

Toxicon, 2019
Dongting Zhangsun, Yong Wu, Manqi Zhangsun, Xiaopeng Zhu, Jinpeng Yu, Jie Ren, Q. Kaas, P. Harvey, D. Craik, J. McIntosh, S. Luo   +10 more
semanticscholar   +1 more source