α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice [PDF]
Marine Drugs, 2020 Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom.
Xiaodan Li +6 more
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AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology. [PDF]
Br J Pharmacol, 2015 The α3β4 subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediating nicotine reinforcement processes. AT-1001 has been recently described as a high-affinity and selective α3β4 nAChR antagonist that blocks nicotine self ...
Cippitelli A +13 more
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Marine Drugs, 2022 α6β4 nAChR is expressed in the peripheral and central nervous systems and is associated with pain, addiction, and movement disorders. Natural α-conotoxins (α-CTxs) can effectively block different nAChR subtypes with higher efficacy and selectivity ...
Liujun Wang +5 more
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Marine Drugs, 2022 Neuronal nicotinic acetylcholine receptors (nAChRs) are important ion channel membrane proteins that are widely distributed in the central nervous system (CNS) and peripheral nervous system (PNS).
Meiling Huang +5 more
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Cell surface localization of α3β4 nicotinic acetylcholine receptors is regulated by N-cadherin homotypic binding and actomyosin contractility. [PDF]
PLoS ONE, 2013 Neuronal nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central and peripheral nervous system and are localized at synaptic and extrasynaptic sites of the cell membrane.
Juan L Brusés
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The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. [PDF]
Behav Brain Res, 2017 The strong reinforcing effects of nicotine and the negative symptoms such as anxiety experienced during a quit attempt often lead to relapse and low success rates for smoking cessation.
Yuan M +5 more
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Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion. [PDF]
Eur J NeurosciABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Ciscato M, Chouvaeff M, Mourot A.
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Marine Drugs, 2022 Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in
Yuan Ma +9 more
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The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes [PDF]
Protein & Cell, 2017 The α3* nAChRs, which are considered to be promising drug targets for problems such as pain, addiction, cardiovascular function, cognitive disorders etc., are found throughout the central and peripheral nervous system.
Manyu Xu +5 more
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Nicotinic acetylcholine receptors in pain modulation [PDF]
Frontiers in PharmacologyChronic pain is widely recognized as a major global health problem that affects approximately one-fifth of the adult population and is associated with significant physical, psychological, and socioeconomic burden.
Junya Cheng, Junliang Chang, Shuai Li
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