Multifactorial Etiology of Adolescent Nicotine Addiction: A Review of the Neurobiology of Nicotine Addiction and Its Implications for Smoking Cessation Pharmacotherapy [PDF]
Frontiers in Public Health, 2021 Nicotine is the primary pharmacologic component of tobacco, and its highly addictive nature is responsible for its widespread use and significant withdrawal effects that result in challenges to smoking cessation therapeutics.
Supriya D Mahajan +2 more
exaly +4 more sources
Mechanisms of Nicotine Addiction. [PDF]
Cold Spring Harb Perspect Med, 2021 Tobacco smoking results in more than five million deaths each year and accounts for ∼90% of all deaths from lung cancer.3 Nicotine, the major reinforcing component of tobacco smoke, acts in the brain through the neuronal nicotinic acetylcholine receptors (nAChRs).
Picciotto MR, Kenny PJ.
europepmc +4 more sources
Hippocampal Metabolomics Reveal the Mechanism of α-Conotoxin [S9K]TxID Attenuating Nicotine Addiction [PDF]
Marine DrugsNicotine is the main substance responsible for the development of tobacco addiction. The α3β4 nicotinic acetylcholine receptors (nAChRs) are a potential key target for mitigating nicotine reward.
Meiting Wang +9 more
doaj +2 more sources
Pathways and Networks-Based Analysis of Candidate Genes Associated with Nicotine Addiction [PDF]
PLoS ONE, 2015 Nicotine is the addictive substance in tobacco and it has a broad impact on both the central and peripheral nervous systems. Over the past decades, an increasing number of genes potentially involved in nicotine addiction have been identified by different
Rui Fan, Xinhua Liu, Feng Cheng
exaly +2 more sources
Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction [PDF]
Frontiers in NeuroscienceNicotine, recognized as the principal addictive component in tobacco, is mechanistically linked to its interaction with neuronal nicotinic acetylcholine receptors (nAChRs).
Jian Jiang +7 more
doaj +2 more sources
Glycyrrhizic acid mitigates the risk of nicotine addiction and nicotine withdrawal: The modulation of kynurenine aminotransferase II [PDF]
Journal of Advanced Pharmaceutical Technology & ResearchNicotine, a key addictive compound in cigarettes, contributes to withdrawal symptoms that hinder smoking cessation success. Understanding the neurochemical basis of nicotine addiction and withdrawal is critical for developing effective therapies.
Mahardian Rahmadi +5 more
doaj +2 more sources
Assessing Perceptions and Behaviors Related to Vaping Nicotine: The Nicotine Addiction Perceptions Scale [PDF]
Tobacco Use InsightsBackground Existent research examining perceptions of nicotine addiction use largely surface level items that fail to address the complexity of nicotine addiction.
Allison A. Temourian +2 more
doaj +2 more sources
Combining neuroimaging and brain stimulation to test alternative causal pathways for nicotine addiction in schizophrenia [PDF]
Brain StimulationThe smoking rate is high in patients with schizophrenia. Brain stimulation targeting conventional brain circuits associated with nicotine addiction has also yielded mixed results.
Xiaoming Du +16 more
doaj +2 more sources
A single-center case-control study of the association between dorsal striatal damage and nicotine addiction [PDF]
Frontiers in NeurologyBackgroundSmoking is closely linked to pulmonary diseases, cardiovascular diseases, cancer, and other health issues, posing a significant threat to human health.
Chuya Jing +20 more
doaj +2 more sources
Nicotine Addiction: Neurobiology and Mechanism. [PDF]
J Pharmacopuncture, 2020 Nicotine, primary component of tobaco produces craving and withdrawal effect both in humans and animals. Nicotine shows a close resemblance to other addictive drugs in molecular, neuroanatomical and pharmacological, particularly the drugs which enhances the cognitive functions.
Tiwari RK +3 more
europepmc +5 more sources