Results 31 to 40 of about 265,934 (241)

Personalized dosing of nicotine replacement therapy versus standard dosing for the treatment of individuals with tobacco dependence: study protocol for a randomized placebo-controlled trial

Trials, 2020
Background Medications for smoking cessation are currently only effective in helping a minority of smokers quit. Drug development is slow and expensive; as such, there is much interest in optimizing the effectiveness of existing treatments and ...
Laurie Zawertailo, Christian S. Hendershot, Rachel F. Tyndale, Bernard Le Foll, Andriy V. Samokhvalov, Kevin E. Thorpe, Andrew Pipe, Robert D. Reid, Peter Selby   +8 more
doaj   +1 more source

Improved treatment of nicotine addiction and emerging pulmonary drug delivery [PDF]

, 2012
Nicotine addiction remains the leading cause of death and disease in developed and developing nations and a major cause of mortality around the world.
Rahman, Shafiqur, Islam, Nazrul
core   +1 more source

SUATU KAJIAN MOLEKULER KETERGANTUNGAN NIKOTIN

Jurnal Farmasi Sains dan Komunitas, 2016
: Nicotine, a simple chemical substance from tobacco, stimulates addiction by neuroadaptation inducing rewards system in human brain. Molecular mechanism of nicotine addiction in rewards system are mediated by nicotinic acetylcholine receptor (nAChR) and 
Agustina Setiawati
doaj   +1 more source

Reward responsivity and the development of nicotine dependence

, 2008
Different theories have been proposed to explain the development of nicotine dependence. Some theories suggest that nicotine has direct reinforcing properties, either positive or negative.
Kalamboka, Natasha
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Study on Nicotine Dependency Levels of Smoking University Students Depending On Socio-Demographic Features, and Smoking Habits

Tobacco Induced Diseases, 2018
Smoking is a common addictive behavior found among young people particularly university students. In the case of smoking addiction the substance nicotine has the most important influence. Therefore, in the fight against smoking addiction it is considered
Canan Yoruk, Görkem Yararbas
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lateral Habenula contribution in Nicotine addiction : focus on Dopamine, GABA and Serotonin Interactions [PDF]

, 2011
Compelling evidence has shown a pivotal role of dopaminergic function in drug addiction. Recently, the Habenula (Hb) has attracted a great deal of attention as another target for nicotine in the brain because of its role in regulating dopamine (DA ...
Zammit, Christian, Zammit C, Di Giovanni, Giuseppe, Muscat, Richard, Pitruzzella A, Muscat R, Pierucci M, Valentino, Mario, Benigno, Arcangelo, Di Giovanni G., Pierucci, Massimo, Valentino M, Pitruzzella, Alessandro   +12 more
core  

If the data contradict the theory, throw out the data: Nicotine addiction in the 2010 report of the Surgeon General

Harm Reduction Journal, 2011
The reports of US Surgeon General on smoking are considered the authoritative statement on the scientific state of the art in this field. The previous report on nicotine addiction published in 1988 is one of the most cited references in scientific ...
Frenk Hanan, Dar Reuven
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source