Results 31 to 40 of about 1,665 (158)

Epigallocatechin Gallate Ameliorates Nicotine Withdrawal Conditions‐Induced Somatic and Affective Behavior Changes in Mice and Its Molecular Mechanism

Behavioural Neurology, Volume 2023, Issue 1, 2023., 2023
In nicotine withdrawal (NW) conditions, molecular changes, such as increasing corticotropin‐releasing factor (CRF) in the amygdala, and melanocortin signaling in the hypothalamus, can occur in the brain, leading to increased feeding behavior and body weight as somatic changes as well as high anxiety‐like behavior as an affective changes.
Mahardian Rahmadi, Ahmad D. Nurhan, Retno I. A. Rahmawati, Theresia F. Damayanti, Djoko A. Purwanto, Junaidi Khotib, Enzo Emanuele   +6 more
wiley   +1 more source

Different efficiency of auxiliary/chaperone proteins to promote the functional reconstitution of honeybee glutamate and acetylcholine receptors in Xenopus laevis oocytes

Insect Molecular Biology, Volume 31, Issue 5, Page 620-633, October 2022., 2022
Insect ionotropic receptors are difficult to express in heterologous system. Honeybee GluR‐1 is functional when co‐expressed with honeybee chaperone proteins but not α7, α2α8β1 and α2α7α8β1 nAChRs. Expression of α1‐containing nAChRs critically depends on α1 N terminus.
Lorène Brunello, Claudine Ménard, Matthieu Rousset, Michel Vignes, Pierre Charnet, Thierry Cens   +5 more
wiley   +1 more source

(−)-Adaline from the Adalia Genus of Ladybirds Is a Potent Antagonist of Insect and Specific Mammalian Nicotinic Acetylcholine Receptors

Molecules, 2022
Ladybird beetles (Coleoptera: Coccinellidae) possess strong chemical defences that are secreted in response to stress and are also found on the coating of eggs, which are rich in alkaloids that are responsible for their toxicity to other species.
David P. Richards, Rohit N. Patel, Ian R. Duce, Bhupinder P. S. Khambay, Michael A. Birkett, John A. Pickett, Ian R. Mellor   +6 more
doaj   +1 more source

Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of α4β2- nicotinic acetylcholine receptor intracellular structures.

PLoS ONE, 2021
Sleep-related hypermotor epilepsy (SHE) is a group of seizure disorders prominently associated with mutations in nicotinic acetylcholine receptors (nAChR). The most prevalent central nervous system nAChR subtype contains α4 and β2 subunits, in two ratios.
Maegan M Weltzin, Andrew A George, Ronald J Lukas, Paul Whiteaker   +3 more
doaj   +1 more source

Degradation kinetics of α‐conotoxin TxID

FEBS Open Bio, 2019
α‐Conotoxin (CTx) TxID is a potent α3β4 nicotinic acetylcholine receptor (nAChR) antagonist that has been suggested as a potential drug candidate to treat addiction and small cell lung cancer.
Pan Xu, Yang Xiong, Yiqiao Liu, Shurun Yu, Dongting Zhangsun, Yong Wu, Sulan Luo   +6 more
doaj   +1 more source

(-)-Pentylsedinine, a New Alkaloid from the Leaves of with Agonist Activity at Nicotinic Acetylcholine Receptor

Natural Product Communications, 2015
Lobelia tupa , also called devil's tobacco, is a native plant from the center-south of Chile which has been used by the native people of Chile as a hallucinogenic and anesthetic plant.
Cristian Paz, José Becerra, Mario Silva, Viviana Burgos, Matthias Heydenreich, Bernd Schmidt, Thu Tran, Irina Vetter   +7 more
doaj   +1 more source

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

Frontiers in Pharmacology, 2017
(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, using [125I ...
Teagan R. Wall, Brandon J. Henderson, George Voren, Charles R. Wageman, Purnima Deshpande, Bruce N. Cohen, Sharon R. Grady, Michael J. Marks, Michael J. Marks, Daniel Yohannes, Paul J. Kenny, Merouane Bencherif, Henry A. Lester   +12 more
doaj   +1 more source

High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes

SLAS Discovery, 2022
There is substantial evidence that in addition to nicotine, other compounds found in tobacco smoke significantly influence smoking behavior. Further, recent years have seen an explosion in the availability of non-combusted products that deliver nicotine,
Michelle Kassner, J. Brek Eaton, Nanyun Tang, Joachim L. Petit, Nathalie Meurice, Hongwei Holly Yin, Paul Whiteaker   +6 more
doaj   +1 more source

Alterations in Neuronal Nicotinic Acetylcholine Receptors in the Pathogenesis of Various Cognitive Impairments. [PDF]

CNS Neurosci Ther
Changes of neuronal nAChRs in various cognitive impairments. The function of nAChRs is related to learning and memory and anti‐neurotoxicity. The modifications of nAChRs have their characteristics in different cognitive impairments. A variety of nAChR agonists and inhibitors have been and are being tested for treatment of cognitive impairment ...
Guan ZZ.
europepmc   +2 more sources

Suggested conserved amino acid sequence for reversal of α3β4 nAChR inhibition by Aβ.

, 2013
Suggested conserved amino acid sequence for reversal of α3β4 nAChR inhibition by Aβ.
Cleber A. Trujillo (350391), Luciana B. Sathler (435560), Sergio T. Ferreira (310090), Luiz Juliano (56592), Arthur A. Nery (435559), Margaret H. Magdesian (347034), Henning Ulrich (184271), Maria A. Juliano (92351)   +7 more
core   +1 more source