Results 51 to 60 of about 1,665 (158)

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, Volume 46, Issue 1, Page 179-197, January 2026.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

GLP‐1 Agonist Attenuates Nicotine Reward‐Related Behavior by Regulating the Prepro‐Orexin in the Hypothalamus and Prepro‐Glucagon in the Nucleus Tractus Solitarius

Behavioural Neurology, Volume 2026, Issue 1, 2026.
Tobacco consumption has significantly increased globally, contributing to various degenerative diseases such as lung cancer and cardiovascular disorders. Nicotine, the primary addictive component in tobacco, exerts its effects by stimulating nicotinic acetylcholine receptors (nAChRs), leading to excessive dopamine release in the ventral tegmental area (
M. Rahmadi, C. Ardianto, R. Rodsiri, D. Anggraini, A. P. S. A. Firdaussy, I. N. B. Sumartha, A. D. Nurhan, Mohd Salman   +7 more
wiley   +1 more source

Monkey adrenal chromaffin cells express α6β4* nicotinic acetylcholine receptors. [PDF]

PLoS ONE, 2014
Nicotinic acetylcholine receptors (nAChRs) that contain α6 and β4 subunits have been demonstrated functionally in human adrenal chromaffin cells, rat dorsal root ganglion neurons, and on noradrenergic terminals in the hippocampus of adolescent mice.
Alicia Hernández-Vivanco, Arik J Hone, Mick L Scadden, Beatriz Carmona-Hidalgo, J Michael McIntosh, Almudena Albillos   +5 more
doaj   +1 more source

Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor.

PLoS ONE, 2013
BackgroundThe cholinergic anti-inflammatory pathway is an endogenous mechanism by which the autonomic nervous system attenuates macrophage activation via nicotinic acetylcholine receptors (nAChR).
Andrea Nemethova, Klaus Michel, Pedro J Gomez-Pinilla, Guy E Boeckxstaens, Michael Schemann   +4 more
doaj   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies

ChemMedChem, Volume 20, Issue 20, October 15, 2025.
Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean‐François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: the first report on the mode of action. [PDF]

PLoS ONE, 2011
Asperparalines produced by Aspergillus japonicus JV-23 induce paralysis in silkworm (Bombyx mori) larvae, but the target underlying insect toxicity remains unknown. In the present study, we have investigated the actions of asperparaline A on ligand-gated
Koichi Hirata, Saori Kataoka, Shogo Furutani, Hideo Hayashi, Kazuhiko Matsuda   +4 more
doaj   +1 more source

Cross Talk between α7 and α3β4 Nicotinic Receptors Prevents Their Desensitization in Human Chromaffin Cells

, 2021
The physical interaction and functional cross talk among the different subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) expressed in the various tissues is unknown. Here, we have investigated this issue between the only two nAChRs subtypes
Medina-Polo, José, Jesús Blázquez, Ewere Omodolor, Romidan, Sanz-Lázaro, Sara, Sanz Lázaro, Sara, Sara Sanz-Lázaro, José Medina-Polo, Jiménez Pompa, Amanda, Almudena Albillos, Albillos, Almudena, Omodolor, Romidan Ewere, Medina Polo, José, McIntosh, J. Michael, Albillos Martínez, María Almudena, McIntosh, J Michael, Carmen González-Enguita, Blázquez, Jesús, González Enguita, Carmen, Jiménez-Pompa, Amanda, Romidan Ewere Omodolor, González-Enguita, Carmen, J. Michael McIntosh, Amanda Jiménez-Pompa   +22 more
core   +1 more source

α7 Nicotinic acetylcholine receptor-specific antibody induces inflammation and amyloid β42 accumulation in the mouse brain to impair memory.

PLoS ONE, 2015
Nicotinic acetylcholine receptors (nAChRs) expressed in the brain are involved in regulating cognitive functions, as well as inflammatory reactions. Their density is decreased upon Alzheimer disease accompanied by accumulation of β-amyloid (Aβ42), memory
Olena Lykhmus, Larysa Voytenko, Lyudmyla Koval, Sergiy Mykhalskiy, Victor Kholin, Kateryna Peschana, Marios Zouridakis, Socrates Tzartos, Sergiy Komisarenko, Maryna Skok   +9 more
doaj   +1 more source

Rescue of amyloid-Beta-induced inhibition of nicotinic acetylcholine receptors by a peptide homologous to the nicotine binding domain of the alpha 7 subtype.

PLoS ONE, 2013
Alzheimer's disease (AD) is characterized by brain accumulation of the neurotoxic amyloid-β peptide (Aβ) and by loss of cholinergic neurons and nicotinic acetylcholine receptors (nAChRs).
Arthur A Nery, Margaret H Magdesian, Cleber A Trujillo, Luciana B Sathler, Maria A Juliano, Luiz Juliano, Henning Ulrich, Sergio T Ferreira   +7 more
doaj   +1 more source