Results 71 to 80 of about 1,665 (158)
Computational Design of α‐Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes
Chemistry – A European Journal, Volume 30, Issue 7, February 1, 2024.FoldX was benchmarked as the best energy prediction method, and seven accurate molecular models of α‐conotoxin/nAChRs were developed as surrogates for the experimental complexes. The combined use of FoldX and these molecular models emerged as an effective approach to predict α‐conotoxins with improved pharmaceutical properties.
Xiaosa Wu +6 more
wiley +1 more source
, 2016 A liquid chromatographic column containing immobilized α3β4 nicotinic acetylcholine receptors (α3β4-nAChRs) has been used to determine the equilibrium association constants (Ka), desorption rate constants (kd), and adsorption rate constants (ka) for the ...
Irving W. Wainer (2299381) +3 more
core +1 more source
The FASEB Journal, Volume 38, Issue 1, 15 January 2024.Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J.
Andrew A. George +12 more
wiley +1 more source
Frontiers in Human Neuroscience, 2014 The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3 and β4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. The habenulo-interpeduncular (Hb-IPN) tract is particularly enriched in α3β4 nAChRs.
Marta A Ślimak +9 more
doaj +1 more source
, 2015 Opioids are excellent pain relievers. A major side-effect of chronic opioid treatment is constipation whereas withdrawal following chronic exposure leads to diarrhea and increased gastrointestinal motility.
Gade, Aravind
core +1 more source
Nicotinic acetylcholine receptors mediate lung cancer growth
Frontiers in Physiology, 2013 Ion channels modulate ion flux across cell membranes, activate signal transduction pathways, and influence cellular transport – vital biological functions that are inexorably linked to cellular processes that go awry during carcinogenesis.
Ma. Reina eImprogo +3 more
doaj +1 more source
Synthesis and Evaluation of the Aristotelia Alkaloids at the α3β4 Nicotinic Acetylcholine Receptor
Substance use disorders remain a major public health concern in the United States, affecting over 48 million individuals in 2024. Yet, while nearly a third of all overdose deaths in the US have been linked to stimulants like cocaine, there are currently ...
Lisa E. Rusali (11172039)
core +1 more source
Arecoline activation of other nAChR subtypes.
, 2015 100 μM arecoline was applied to cells expressing the nAChR subunits indicated. Responses of human α3β4, α7, and mouse muscle (α1β1εδ) subunits were barely at the threshold of detection, less than 1% the ACh maximum, extrapolated from comparisons to ACh ...
Clare Stokes (816556) +2 more
core +1 more source
Scientific ReportsNicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related behaviors.
Asuka Tsuzuki +7 more
doaj +1 more source
Effects of Chronic Menthol at Alpha3Beta4 (α3β4)-Containing Nicotinic Acetylcholine Receptors
, 2018 Some heteropentameric nicotinic acetylcholine receptors (nAChRs) are up-regulated by chronic nicotine. Menthol is present in ∼ 30% of tobacco cigarettes sold in the United States.
Patowary, Suparna +4 more
core