Results 71 to 80 of about 10,698 (157)

Alterations in Neuronal Nicotinic Acetylcholine Receptors in the Pathogenesis of Various Cognitive Impairments

CNS Neuroscience &Therapeutics, Volume 30, Issue 10, October 2024.
Changes of neuronal nAChRs in various cognitive impairments. The function of nAChRs is related to learning and memory and anti‐neurotoxicity. The modifications of nAChRs have their characteristics in different cognitive impairments. A variety of nAChR agonists and inhibitors have been and are being tested for treatment of cognitive impairment ...
Zhi‐Zhong Guan
wiley   +1 more source

The human‐specific nicotinic receptor subunit CHRFAM7A reduces α7 receptor function in human induced pluripotent stem cells‐derived and transgenic mouse neurons

European Journal of Neuroscience, Volume 60, Issue 5, Page 4893-4906, September 2024.
Abstract We investigated the impact of the human‐specific gene CHRFAM7A on the function of α7 nicotinic acetylcholine receptors (α7 nAChRs) in two different types of neurons: human‐induced pluripotent stem cell (hiPSC)‐derived cortical neurons, and superior cervical ganglion (SCG) neurons, taken from transgenic mice expressing CHRFAM7A. dupα7, the gene
Ilayda Görgülü, Vinita Jagannath, Stephanie Pons, Filip Koniuszewski, Matthias Groszer, Uwe Maskos, Sigismund Huck, Petra Scholze   +7 more
wiley   +1 more source

Computational Design of α‐Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes

Chemistry – A European Journal, Volume 30, Issue 7, February 1, 2024.
FoldX was benchmarked as the best energy prediction method, and seven accurate molecular models of α‐conotoxin/nAChRs were developed as surrogates for the experimental complexes. The combined use of FoldX and these molecular models emerged as an effective approach to predict α‐conotoxins with improved pharmaceutical properties.
Xiaosa Wu, Arik J. Hone, Yen‐Hua Huang, Richard J. Clark, J. Michael McIntosh, Quentin Kaas, David J. Craik   +6 more
wiley   +1 more source

Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption

Frontiers in Human Neuroscience, 2014
The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3 and β4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. The habenulo-interpeduncular (Hb-IPN) tract is particularly enriched in α3β4 nAChRs.
Marta A Ślimak, Jessica L Ables, Silke eFrahm, Beatriz eAntolin-Fontes, Beatriz eAntolin-Fontes, Julio eSantos-Torres, Milena eMoretti, Cecilia eGotti, Ines eIbañez-Tallon, Ines eIbañez-Tallon   +9 more
doaj   +1 more source

Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism

The FASEB Journal, Volume 38, Issue 1, 15 January 2024.
Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J.
Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J. Michael McIntosh, Paul Whiteaker   +12 more
wiley   +1 more source

Displacement and Nonlinear Chromatographic Techniques in the Investigation of Interaction of Noncompetitive Inhibitors with an Immobilized α3β4 Nicotinic Acetylcholine Receptor Liquid Chromatographic Stationary Phase

, 2016
A liquid chromatographic column containing immobilized α3β4 nicotinic acetylcholine receptors (α3β4-nAChRs) has been used to determine the equilibrium association constants (Ka), desorption rate constants (kd), and adsorption rate constants (ka) for the ...
Irving W. Wainer (2299381), Jun Haginaka (2942976), Krzysztof Jozwiak (1307436), Ruin Moaddel (442934)   +3 more
core   +1 more source

Nicotinic acetylcholine receptors mediate lung cancer growth

Frontiers in Physiology, 2013
Ion channels modulate ion flux across cell membranes, activate signal transduction pathways, and influence cellular transport – vital biological functions that are inexorably linked to cellular processes that go awry during carcinogenesis.
Ma. Reina eImprogo, Lindsey G Soll, Andrew R Tapper, Paul D Gardner   +3 more
doaj   +1 more source

Synthesis and Evaluation of the Aristotelia Alkaloids at the α3β4 Nicotinic Acetylcholine Receptor

Substance use disorders remain a major public health concern in the United States, affecting over 48 million individuals in 2024. Yet, while nearly a third of all overdose deaths in the US have been linked to stimulants like cocaine, there are currently ...
Lisa E. Rusali (11172039)
core   +1 more source

Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus

Marine Drugs
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating ...
Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak   +19 more
doaj   +1 more source

Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice

Scientific Reports
Nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related behaviors.
Asuka Tsuzuki, Miwako Yamasaki, Kohtarou Konno, Taisuke Miyazaki, Norio Takei, Susumu Tomita, Michisuke Yuzaki, Masahiko Watanabe   +7 more
doaj   +1 more source