Results 91 to 100 of about 10,698 (157)

Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies

, 2013
Nicotine binds to nicotinic acetylcholine receptors (nAChR), which can exist as many different subtypes. The α4β2 nAChR is the most prevalent subtype in the brain and possesses the most evidence linking it to nicotine seeking behavior.
Santos, Radleigh, LaVoi, Travis, Toll, Lawrence, Yu, Yongping, Giulianotti, Marc, Houghten, Richard A., Zhang, Yaohong, Nefzi, Adel, Wu, Jinhua, Maida, Laura E., Welmaker, Greg   +10 more
core   +1 more source

Effects of asperparaline A on the ACh-induced responses of chicken α3β4 (A), α4β2 (B) and α7 (C) nAChRs expressed in Xenopus laevis oocytes.

, 2013
After three successive control applications of ACh, 10 µM asperparaline A was continuously bath-applied and then co-applied with 100 µM ACh. Asperparaline A blocked the ACh-response of
Saori Kataoka (353742), Koichi Hirata (52794), Kazuhiko Matsuda (353746), Hideo Hayashi (353744), Shogo Furutani (353743)   +4 more
core   +1 more source

Nachr subtypes present in the rodent habenulo-interpeduncular pathway and their involvement in 3h-acetylcholine release

, 2008
The habenula (Hb) is a diencephalic structure that receives substantial input from multiple parts of the limbic system, and communicates with the nucleus interpeduncularis (IPN) by means of the fasciculus retroflexus.
A. Zanardi, F. Clementi, L. Pucci, M. Marks, A. Collins, C. Gotti, M. Moretti, M. Zoli, S. Grady   +8 more
core   +2 more sources

Structural differences determine the relative selectivity of nicotinic compounds for native α4β2^*-, α6β2^*-, α3β4^*- and α7-nicotine acetylcholine receptors [PDF]

, 2010
Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and pharmacological and functional properties.
Breining, Scott R., Drenan, Ryan M., Fedorov, Nikolai B., Bencherif, Merouane, Whiteaker, Paul, Lester, Henry A., Yohannes, Daniel, Grady, Sharon R., Marks, Michael J., Wageman, Charles R., McKinney, Sheri   +10 more
core  

Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001. [PDF]

Neuropharmacology, 2015
Cippitelli A, Brunori G, Gaiolini KA, Zaveri NT, Toll L.   +4 more
europepmc   +1 more source

Co-activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
Lee R, Kim G, Black ER, Kim S.
europepmc   +1 more source

Nicotinic Agonist Inhibits Cardiomyocyte Apoptosis in CVB3-Induced Myocarditis via α3β4-nAChR/PI3K/Akt-Dependent Survivin Upregulation. [PDF]

Oxid Med Cell Longev, 2019
Li P, Yan Y, Shi Y, Cheng B, Zhan Y, Wang Q, Ye Q, Weng Y, Wu T, Wu R.   +9 more
europepmc   +1 more source

Toxicological and pharmacodynamic evaluation of Nixodine-S [(S)-6-Methylnicotine] relative to (S)-nicotine. [PDF]

Toxicol Rep
Smith ML, Costigan S, Campbell JP, Avila R, Weil RE, McKinney WJ.   +5 more
europepmc   +1 more source

An accessory orthosteric ligand binding site in the (α3)₃(β4)₂ nicotinic acetylcholine receptor regulates channel activation. [PDF]

Cell Rep
Kulkarni GC, Jurek MJ, Riley AP, Peters CJ.   +3 more
europepmc   +1 more source

Sustained abstinence in severe ketamine use disorder following ibogaine treatment case report. [PDF]

Front Psychiatry
Pérez Rosal SR, Faber SC, Backmund M.
europepmc   +1 more source