Results 91 to 100 of about 1,665 (158)

Evaluation of (S)-T1 and (S)-T2 ligands targeting α3β4 nAChR as potential nicotine addiction pharmacotherapy [PDF]

Objectives Substance use disorders (SUDs) represent a significant global health concern, demanding the development of effective pharmacological treatments.
Limpikirati, Patanachai, Rodsiri, Ratchanee, Thanusuwannasak, Thanundorn, Islamie, Ridho, Vajragupta, Opa, Sarasamkan, Jiradanai, Nianpanich, Saranda, Kanasuwan, Apinan   +7 more
core   +1 more source

Structure-function Analysis of α-conotoxin PeIA and the Inhibition of Rat α3β4 Nicotinic Acetylcholine Receptors

, 2018
posterThe α3β4 nicotinic acetylcholine receptor (nAChR) subtype is widely expressed by neurons of the peripheral nervous system including those of dorsal root ganglion (DRG).
Kearns, Ireland
core  

α3-myc and β4-myc nAChR subunits form functional ligand-activated ion channels in CHO cells.

, 2013
A) Schematic drawing of nAChR subunits C-terminally fused to a 6X-myc tag localized to the extracellular side of the cell membrane. B) Confocal image of a CHO cell transfected with α3-myc and β4-myc and cell surface labeled with anti-myc antibodies shows
Juan L. Brusés (406197)
core   +1 more source

Synthesis and Biological Evaluation of Bupropion Analogues as Potential Pharmacotherapies for Smoking Cessation

, 2016
Bupropion (2a) analogues were synthesized and tested for their ability to inhibit monoamine uptake and to antagonize the effects of human α3β4*, α4β2, α4β4, and α1* nAChRs.
Ronald J. Lukas (781724), S. Wayne Mascarella (1307766), Hernán A. Navarro (1309674), F. Ivy Carroll (445446), J. Brek Eaton (1343394), Bruce E. Blough (1322406), M. Imad Damaj (296657)   +6 more
core   +1 more source

Molekulare Determinanten der β4-nAChr-Untereinheit in Kanal-Funktion und Nikotin-assoziiertem Verhalten

, 2012
These studies establish that the β4 nicotinic receptor subunit regulates nicotine intake and nociception in mice and identify the residues in this molecule that control α3β4 nAChR channel activity.
Slimak, Marta Anna
core   +1 more source

Structural differences determine the relative selectivity of nicotinic compounds for native α4β2^*-, α6β2^*-, α3β4^*- and α7-nicotine acetylcholine receptors [PDF]

, 2010
Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and pharmacological and functional properties.
Breining, Scott R., Drenan, Ryan M., Fedorov, Nikolai B., Bencherif, Merouane, Whiteaker, Paul, Lester, Henry A., Yohannes, Daniel, Grady, Sharon R., Marks, Michael J., Wageman, Charles R., McKinney, Sheri   +10 more
core  

Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001. [PDF]

Neuropharmacology, 2015
Cippitelli A, Brunori G, Gaiolini KA, Zaveri NT, Toll L.   +4 more
europepmc   +1 more source

Nachr subtypes present in the rodent habenulo-interpeduncular pathway and their involvement in 3h-acetylcholine release

, 2008
The habenula (Hb) is a diencephalic structure that receives substantial input from multiple parts of the limbic system, and communicates with the nucleus interpeduncularis (IPN) by means of the fasciculus retroflexus.
A. Zanardi, F. Clementi, L. Pucci, M. Marks, A. Collins, C. Gotti, M. Moretti, M. Zoli, S. Grady   +8 more
core  

Nicotinic Agonist Inhibits Cardiomyocyte Apoptosis in CVB3-Induced Myocarditis via α3β4-nAChR/PI3K/Akt-Dependent Survivin Upregulation. [PDF]

Oxid Med Cell Longev, 2019
Li P, Yan Y, Shi Y, Cheng B, Zhan Y, Wang Q, Ye Q, Weng Y, Wu T, Wu R.   +9 more
europepmc   +1 more source

An accessory orthosteric ligand binding site in the (α3)₃(β4)₂ nicotinic acetylcholine receptor regulates channel activation. [PDF]

Cell Rep
Kulkarni GC, Jurek MJ, Riley AP, Peters CJ.   +3 more
europepmc   +1 more source