Results 81 to 90 of about 10,698 (157)

Effects of Chronic Menthol at Alpha3Beta4 (α3β4)-Containing Nicotinic Acetylcholine Receptors

, 2018
Some heteropentameric nicotinic acetylcholine receptors (nAChRs) are up-regulated by chronic nicotine. Menthol is present in ∼ 30% of tobacco cigarettes sold in the United States.
Patowary, Suparna, Kim, Charlene H., Lester, Henry A., Henderson, Brandon J., Bavan, Selvan   +4 more
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Arecoline activation of other nAChR subtypes.

, 2015
100 μM arecoline was applied to cells expressing the nAChR subunits indicated. Responses of human α3β4, α7, and mouse muscle (α1β1εδ) subunits were barely at the threshold of detection, less than 1% the ACh maximum, extrapolated from comparisons to ACh ...
Clare Stokes (816556), Nicole A. Horenstein (816555), Roger L. Papke (685990)   +2 more
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Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor

Marine Drugs, 2018
α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype.
Jie Ren, Rui Li, Jiong Ning, Xiaopeng Zhu, Dongting Zhangsun, Yong Wu, Sulan Luo   +6 more
doaj   +1 more source

Neuronal nicotinic acetylcholine receptor antibodies in autoimmune central nervous system disorders

Frontiers in Immunology
BackgroundNeuronal nicotinic acetylcholine receptors (nAChRs) are abundant in the central nervous system (CNS), playing critical roles in brain function. Antigenicity of nAChRs has been well demonstrated with antibodies to ganglionic AChR subtypes (i.e.,
Maria Pechlivanidou, Aigli G. Vakrakou, Katerina Karagiorgou, Katerina Karagiorgou, Erdem Tüzün, Eleni Karachaliou, Eleni Karachaliou, Elisabeth Chroni, Theodora Afrantou, Nikolaos Grigoriadis, Christina Argyropoulou, Nikolaos Paschalidis, Elif Şanlı, Aikaterini Tsantila, Maria Dandoulaki, Elpinickie I. Ninou, Paraskevi Zisimopoulou, Renato Mantegazza, Francesca Andreetta, Leon Dudeck, Johann Steiner, Jon Martin Lindstrom, Dimitrios Tzanetakos, Konstantinos Voumvourakis, Sotirios Giannopoulos, Georgios Tsivgoulis, Socrates J. Tzartos, Socrates J. Tzartos, Socrates J. Tzartos, John Tzartos   +29 more
doaj   +1 more source

Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins

, 2016
α-Conotoxins represent a large group of pharmacologically active peptides that antagonize nicotinic acetylcholine receptors (nAChRs). The α3β4 nAChR, a predominant subtype in the peripheral nervous system, has been implicated in various ...
Han Shen Tae (19586293), Hartmut Cuny (20022879), Shiva N Kompella (20211633), David Adams (19587271), Rilei Yu (228408)   +4 more
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α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release

, 1998
Neuronal nicotinic acetylcholine receptors (nAChRs) with putative α3β4-subunits have been implicated in the mediation of signaling in various systems, including ganglionic transmission peripherally and nicotine-evoked neurotransmitter release centrally ...
Siqin Luo, G. Edward Cartier, Jennifer M. Kulak, Doju Yoshikami, Baldomero M. Olivera, Richard B. Jacobsen, J. Michael McIntosh   +6 more
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αB-Conotoxin VxXXIVA differentially blocks α9α10, α7, α3β4 and α4β2 nAChRs.

, 2013
nAChR subtypes were expressed as described in Materials and Methods. “C” indicates control responses to ACh. Oocytes were then exposed to 10 µM peptide for 5 min, followed by application of ACh. The peptide blocked α9α10 but not α7, α3β4 or α4β2 nAChRs.
Sandeep Chhabra (187303), Yuanyan Hu (277908), J. Michael McIntosh (277909), Raymond S. Norton (221364), Sulan Luo (277905), Sean Christensen (277906), Dongting Zhangsun (277907), Yong Wu (165587), Xiaopeng Zhu (16758)   +8 more
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Interaction of Noncompetitive Inhibitors with an Immobilized α3β4 Nicotinic Acetylcholine Receptor Investigated by Affinity Chromatography, Quantitative−Structure Activity Relationship Analysis, and Molecular Docking

, 2016
A large number of drug substances act as noncompetitive inhibitors (NCIs) of the nicotinic acetylcholine receptor (nAChR) by blocking the ion flux through the channel.
Jack R. Collins (17042), Irving W. Wainer (2299381), Krzysztof Jozwiak (1307436), Sarangan Ravichandran (2433616)   +3 more
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Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies

, 2016
Nicotine binds to nicotinic acetylcholine receptors (nAChR), which can exist as many different subtypes. The α4β2 nAChR is the most prevalent subtype in the brain and possesses the most evidence linking it to nicotine seeking behavior.
Travis M. LaVoi (1864786), Laura E. Maida (1864783), Gregory S. Welmaker (1613095), Marc A. Giulianotti (205967), Radleigh G. Santos (205964), Yaohong Zhang (1815328), Lawrence Toll (375148), Adel Nefzi (827946), Jinhua Wu (1399762), Richard A. Houghten (1262139), Yongping Yu (1520146)   +10 more
core   +1 more source

Structure-function Analysis of α-conotoxin PeIA and the Inhibition of Rat α3β4 Nicotinic Acetylcholine Receptors

, 2018
posterThe α3β4 nicotinic acetylcholine receptor (nAChR) subtype is widely expressed by neurons of the peripheral nervous system including those of dorsal root ganglion (DRG).
Kearns, Ireland
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