Results 81 to 90 of about 1,665 (158)

Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor

Marine Drugs, 2018
α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype.
Jie Ren, Rui Li, Jiong Ning, Xiaopeng Zhu, Dongting Zhangsun, Yong Wu, Sulan Luo   +6 more
doaj   +1 more source

Neuronal nicotinic acetylcholine receptor antibodies in autoimmune central nervous system disorders

Frontiers in Immunology
BackgroundNeuronal nicotinic acetylcholine receptors (nAChRs) are abundant in the central nervous system (CNS), playing critical roles in brain function. Antigenicity of nAChRs has been well demonstrated with antibodies to ganglionic AChR subtypes (i.e.,
Maria Pechlivanidou, Aigli G. Vakrakou, Katerina Karagiorgou, Katerina Karagiorgou, Erdem Tüzün, Eleni Karachaliou, Eleni Karachaliou, Elisabeth Chroni, Theodora Afrantou, Nikolaos Grigoriadis, Christina Argyropoulou, Nikolaos Paschalidis, Elif Şanlı, Aikaterini Tsantila, Maria Dandoulaki, Elpinickie I. Ninou, Paraskevi Zisimopoulou, Renato Mantegazza, Francesca Andreetta, Leon Dudeck, Johann Steiner, Jon Martin Lindstrom, Dimitrios Tzanetakos, Konstantinos Voumvourakis, Sotirios Giannopoulos, Georgios Tsivgoulis, Socrates J. Tzartos, Socrates J. Tzartos, Socrates J. Tzartos, John Tzartos   +29 more
doaj   +1 more source

Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor

, 2021
Conotoxins are marine peptide toxins from marine cone snails. The α-conotoxin RegIIA can selectively act on human (h) α3β4 nicotinic acetylcholine receptor (nAChR), and is an important lead for drug development.
Liang Xue (174224), Tao Jiang (28401), Han Shen Tae (20023188), Rilei Yu (228408), Meiling Zheng (4610461)   +4 more
core  

α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release

, 1998
Neuronal nicotinic acetylcholine receptors (nAChRs) with putative α3β4-subunits have been implicated in the mediation of signaling in various systems, including ganglionic transmission peripherally and nicotine-evoked neurotransmitter release centrally ...
Siqin Luo, G. Edward Cartier, Jennifer M. Kulak, Doju Yoshikami, Baldomero M. Olivera, Richard B. Jacobsen, J. Michael McIntosh   +6 more
core   +1 more source

αB-Conotoxin VxXXIVA differentially blocks α9α10, α7, α3β4 and α4β2 nAChRs.

, 2013
nAChR subtypes were expressed as described in Materials and Methods. “C” indicates control responses to ACh. Oocytes were then exposed to 10 µM peptide for 5 min, followed by application of ACh. The peptide blocked α9α10 but not α7, α3β4 or α4β2 nAChRs.
Sandeep Chhabra (187303), Yuanyan Hu (277908), J. Michael McIntosh (277909), Raymond S. Norton (221364), Sulan Luo (277905), Sean Christensen (277906), Dongting Zhangsun (277907), Yong Wu (165587), Xiaopeng Zhu (16758)   +8 more
core   +1 more source

Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins

, 2016
α-Conotoxins represent a large group of pharmacologically active peptides that antagonize nicotinic acetylcholine receptors (nAChRs). The α3β4 nAChR, a predominant subtype in the peripheral nervous system, has been implicated in various ...
Cuny, Hartmut, Adams, David J, Kompella, Shiva N, Tae, Han-Shen, Yu, Rilei   +4 more
core   +1 more source

Interaction of Noncompetitive Inhibitors with an Immobilized α3β4 Nicotinic Acetylcholine Receptor Investigated by Affinity Chromatography, Quantitative−Structure Activity Relationship Analysis, and Molecular Docking

, 2016
A large number of drug substances act as noncompetitive inhibitors (NCIs) of the nicotinic acetylcholine receptor (nAChR) by blocking the ion flux through the channel.
Jack R. Collins (17042), Irving W. Wainer (2299381), Krzysztof Jozwiak (1307436), Sarangan Ravichandran (2433616)   +3 more
core   +1 more source

Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies

, 2016
Nicotine binds to nicotinic acetylcholine receptors (nAChR), which can exist as many different subtypes. The α4β2 nAChR is the most prevalent subtype in the brain and possesses the most evidence linking it to nicotine seeking behavior.
Travis M. LaVoi (1864786), Laura E. Maida (1864783), Gregory S. Welmaker (1613095), Marc A. Giulianotti (205967), Radleigh G. Santos (205964), Yaohong Zhang (1815328), Lawrence Toll (375148), Adel Nefzi (827946), Jinhua Wu (1399762), Richard A. Houghten (1262139), Yongping Yu (1520146)   +10 more
core   +1 more source

Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies

, 2013
Nicotine binds to nicotinic acetylcholine receptors (nAChR), which can exist as many different subtypes. The α4β2 nAChR is the most prevalent subtype in the brain and possesses the most evidence linking it to nicotine seeking behavior.
Santos, Radleigh, LaVoi, Travis, Toll, Lawrence, Yu, Yongping, Giulianotti, Marc, Houghten, Richard A., Zhang, Yaohong, Nefzi, Adel, Wu, Jinhua, Maida, Laura E., Welmaker, Greg   +10 more
core   +1 more source

Effects of asperparaline A on the ACh-induced responses of chicken α3β4 (A), α4β2 (B) and α7 (C) nAChRs expressed in Xenopus laevis oocytes.

, 2013
After three successive control applications of ACh, 10 µM asperparaline A was continuously bath-applied and then co-applied with 100 µM ACh. Asperparaline A blocked the ACh-response of
Saori Kataoka (353742), Koichi Hirata (52794), Kazuhiko Matsuda (353746), Hideo Hayashi (353744), Shogo Furutani (353743)   +4 more
core   +1 more source