Degradation kinetics of α‐conotoxin TxID [PDF]
FEBS Open Bio, 2019 α‐Conotoxin TxID is a potent α3β4 nicotinic acetylcholine receptor (nAChR) antagonist. The stability and forced degradation of TxID under different stress conditions were analyzed. The major degradation products of TxID were analyzed using liquid chromatography–tandem mass spectrometry.
Pan Xu, Dongting Zhangsun, Sulan Luo
exaly +6 more sources
Fluorescently Labeled α-Conotoxin TxID, a New Probe for α3β4 Neuronal Nicotinic Acetylcholine Receptors [PDF]
Marine Drugs, 2022 Neuronal nicotinic acetylcholine receptors (nAChRs) are important ion channel membrane proteins that are widely distributed in the central nervous system (CNS) and peripheral nervous system (PNS).
Meiling Huang +2 more
exaly +6 more sources
DSPE-PEG Modification of α-Conotoxin TxID [PDF]
Marine Drugs, 2019 In order to improve stability of a peptide marine drug lead, α-conotoxin TxID, we synthesized and modified TxID at the N-terminal with DSPE-PEG-NHS by a nucleophilic substitution reaction to prepare the DSPE-PEG-TxID for the first time.
Dongting Zhangsun +2 more
exaly +6 more sources
α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice [PDF]
Marine Drugs, 2020 Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom.
Jinpeng Yu +2 more
exaly +6 more sources
Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor [PDF]
Marine Drugs, 2018 α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype.
Jie Ren, Rui Li, Xiaopeng Zhu
exaly +6 more sources
Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID [PDF]
Marine Drugs, 2023 α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively.
Jianying Dong, Ting Xie, Xiaopeng Zhu
exaly +5 more sources
Hippocampal Metabolomics Reveal the Mechanism of α-Conotoxin [S9K]TxID Attenuating Nicotine Addiction [PDF]
Marine DrugsNicotine is the main substance responsible for the development of tobacco addiction. The α3β4 nicotinic acetylcholine receptors (nAChRs) are a potential key target for mitigating nicotine reward.
Cheng Cui +2 more
exaly +5 more sources
α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors [PDF]
Journal of Medicinal Chemistry, 2017 α3β4 nAChRs have been implicated in various pathophysiological conditions. However, the expression profile of α3β4 nAChRs and α6/α3β4 nAChRs overlap in a variety of tissues.
Dongting Zhangsun +2 more
exaly +4 more sources
Journal of Medicinal Chemistry, 2018 The α3β4 nicotinic acetylcholine receptor (nAChR) is an important target implicated in various disease states. α-Conotoxin TxID (1) is the most potent antagonist of α3β4 nAChR, but it also exhibits inhibition of α6/α3β4 nAChR.
Jinpeng Yu +2 more
exaly +6 more sources
Characterization of a novel alpha-conotoxin TxID from Conus textile that potently blocks rat alpha3/beta4 nicotinic acetylcholine receptors [PDF]
J Med Chem, 2013 The alpha 3 beta 4 nAChRs are implicated in pain sensation in the PNS and addiction to nicotine in the CNS. We identified an alpha-4/6-conotoxin (CTx) TxID from Conus textile.
Wu, Yong +9 more
core +3 more sources