Results 41 to 50 of about 917,242 (94)

Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli

, 2016
α-Conotoxin LvIA is derived from Conus lividus, native to Hainan, and is the most selective inhibitor of α3β2 nicotinic acetylcholine receptors (nAChRs) known to date.
Jinpeng Yu, Xiaopeng Zhu, Sulan Luo, Yaning Zhang, Jianpeng Bi, Dongting Zhangsun, Xiaodan Li   +6 more
core   +1 more source

What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. [PDF]

J Med Chem, 2023
Straub CJ, Rusali LE, Kremiller KM, Riley AP.   +3 more
europepmc   +1 more source

α-Conotoxin PIA Is Selective for α6 Subunit-Containing Nicotinic Acetylcholine Receptors

, 2003
Until now, there have been no antagonists to discriminate between heteromeric nicotinic acetylcholine receptors (nAChRs) containing the very closely related α6 and α3 subunits. nAChRs containing α3, α4, or α6 subunits in combination with β2, occasionally
Baldomero M. Olivera, Doju Yoshikami, Cheryl Dowell, Maren Watkins, Alexander Kuryatov, James E. Garrett, Sarah T. Staheli, Jon M. Lindstrom, J. Michael McIntosh   +8 more
core   +1 more source

Optimizing the connectivity in disulfide-rich peptides: α-conotoxin SII as a case study

, 2005
We describe a strategy for the efficient, unambiguous assignment of disulfide connectivities in α-conotoxin SII, of which ∼30% of its mass is cysteine, as an example of a generalizable technique for investigation of cysteine-rich peptides.
Livett, Bruce G., Broxton, Natalie M., Moczydlowski, Edward G., Jones, Alun, Down, John G., Bingham, Jon-Paul   +5 more
core   +1 more source

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications. [PDF]

Biomolecules, 2022
Kasheverov I, Kudryavtsev D, Shelukhina I, Nikolaev G, Utkin Y, Tsetlin V.   +5 more
europepmc   +1 more source

Discovery of Novel Antinociceptive α‑Conotoxin Analogues from the Direct In Vivo Screening of a Synthetic Mixture-Based Combinatorial Library

, 2016
Marine cone snail venoms consist of large, naturally occurring combinatorial libraries of disulfide-constrained peptide neurotoxins known as conotoxins, which have profound potential in the development of analgesics.
Shainnel O. Eans (1375899), Elisa Mizrachi (1577218), Kate J. Reilley (1983916), Michelle R. Hoot (1983919), Reena Gyanda (1983907), Richard A. Houghten (381453), Christopher J. Armishaw (1983910), Jayati Banerjee (1983913), Michelle L. Ganno (1375911), Jay P. McLaughlin (1375902)   +9 more
core   +1 more source

Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors. [PDF]

Molecules, 2021
Bekbossynova A, Zharylgap A, Filchakova O.   +2 more
europepmc   +1 more source

From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR. [PDF]

Mar Drugs, 2021
Pan S, Fan Y, Zhu X, Xue Y, Luo S, Wang X.   +5 more
europepmc   +1 more source

A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy. [PDF]

Mar Drugs, 2022
Wang L, Wu X, Zhu X, Zhangsun D, Wu Y, Luo S.   +5 more
europepmc   +1 more source

Cross Talk between α7 and α3β4 Nicotinic Receptors Prevents Their Desensitization in Human Chromaffin Cells. [PDF]

J Neurosci, 2022
Jiménez-Pompa A, Sanz-Lázaro S, Omodolor RE, Medina-Polo J, González-Enguita C, Blázquez J, McIntosh JM, Albillos A.   +7 more
europepmc   +1 more source