Results 21 to 30 of about 1,038 (93)

Molecular Determinants of Species Specificity of α-Conotoxin TxIB towards Rat and Human α6/α3β4 Nicotinic Acetylcholine Receptors

International Journal of Molecular Sciences, 2023
Conotoxins are widely distributed and important for studying ligand-gated ion channels. TxIB, a conotoxin consisting of 16 amino acids derived from Conus textile, is a unique selective ligand that blocks rat α6/α3β2β3 nAChR (IC50 = 28 nM) without ...
Ting Xie, Yuan Qin, Jinyuan Zhao, Jianying Dong, Panpan Qi, Panpan Zhang, Dongting Zhangsun, Xiaopeng Zhu, Jinpeng Yu, S. Luo   +9 more
semanticscholar   +1 more source

Mechanism of Action and Structure-Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor.

Journal of Medicinal Chemistry, 2022
α-Conotoxins (α-CTxs) can selectively target nicotinic acetylcholine receptors (nAChRs) and are important drug leads for the treatment of cancer, chronic pain, and neuralgia. Here, we chemically synthesized a formerly defined rat α7 nAChR targeting α-CTx
Jiazhen Liang, Han-Shen Tae, Zitong Zhao, Xiao Li, Jinghui Zhang, Shen Chen, Tao Jiang, David John Adams, Ri-lei Yu   +8 more
semanticscholar   +1 more source

Programmed Aptamer Screening, Characterization, and Rapid Detection for α-Conotoxin MI

Toxins, 2022
Conotoxins (CTXs) are a variety of mixed polypeptide toxins, among which α-conotoxin MI (CTX-MI) is the most toxic. Serious toxic symptoms, a lack of counteracting drugs, and cumbersome detection processes have made CTX-MI a hidden danger for humans. One
Han Guo, Bowen Deng, Luming Zhao, Yun Gao, Xiaojuan Zhang, Chengfang Yang, B. Zou, Han Chen, Mingjuan Sun, Lianghua Wang, B. Jiao   +10 more
semanticscholar   +1 more source

α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal

Frontiers in Pharmacology, 2022
Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Kailin Mao, Xiaodan Li, Zong-Yun Chen, Xiaoqian Dong, Dongting Zhangsun, Xiaopeng Zhu, S. Luo   +6 more
semanticscholar   +1 more source

Research into the Bioengineering of a Novel α-Conotoxin from the Milked Venom of Conus obscurus

International Journal of Molecular Sciences, 2022
The marine cone snail produces one of the fastest prey strikes in the animal kingdom. It injects highly efficacious venom, often causing prey paralysis and death within seconds.
Sean Wiere, Christopher K. Sugai, M. Espiritu, Vincent P. Aurelio, C. D. Reyes, Nicole Yuzon, R. Whittal, J. Tytgat, S. Peigneur, J. Bingham   +9 more
semanticscholar   +1 more source

A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect

Frontiers in Pharmacology, 2022
A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH2), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized.
Shuo Wang, Peter Bartels, Cong Zhao, Arsalan Yousuf, Zhuguo Liu, Shuo Yu, Anuja R. Bony, Xiaoli Ma, Qin Dai, Ting Sun, Na Liu, Meng-qing Yang, Ri-lei Yu, W. Du, David John Adams, Qiuyun Dai   +15 more
semanticscholar   +1 more source

α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice

Marine Drugs
Nicotine addiction is a serious global public health problem, so there is an urgent necessity to develop novel effective smoking cessation treatments with fewer adverse effects.
Weifeng Xu, Meiting Wang, Xiaodan Li, Rongyan He, Ren-bo Ding, Jiaolin Bao, Dongting Zhangsun, Sulan Luo   +7 more
semanticscholar   +1 more source

GABAB Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell‐Derived Sensory Neurons by Baclofen and α‐Conotoxin Vc1.1

Journal of Neurochemistry
GABAB receptor (GABABR) activation is known to alleviate pain by reducing neuronal excitability, primarily through inhibition of high voltage‐activated (HVA) calcium (CaV2.2) channels and potentiating G protein–coupled inwardly rectifying potassium (GIRK)
Mitchell St Clair-Glover, Arsalan Yousuf, Dominic Kaul, M. Dottori, David J. Adams   +4 more
semanticscholar   +1 more source

Engineering Enhanced Antimicrobial Properties in α-Conotoxin RgIA through D-Type Amino Acid Substitution and Incorporation of Lysine and Leucine Residues

Molecules
Antimicrobial peptides (AMPs), acknowledged as host defense peptides, constitute a category of predominant cationic peptides prevalent in diverse life forms. This study explored the antibacterial activity of α-conotoxin RgIA, and to enhance its stability
Minghe Wang, Zhouyuji Liao, Dongting Zhangsun, Yong Wu, S. Luo   +4 more
semanticscholar   +1 more source

Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of α7 Nicotinic Acetylcholine Receptor in the Rat Brain

Marine Drugs
α7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized,
Hongyu Shan, Nan Wang, Xinyu Gao, Zihan Wang, Jinpeng Yu, Dongting Zhangsun, Xiaopeng Zhu, S. Luo   +7 more
semanticscholar   +1 more source