Results 11 to 20 of about 1,038 (93)

Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists [PDF]

J Neurochem, 2020
Adrenal chromaffin cells release neurotransmitters in response to stress and may be involved in conditions such as post-traumatic stress and anxiety disorders.
Lola Rueda‐Ruzafa, Christensen, Sean, Hone, Arik J., Rueda Ruzafa, Lola, Almudena Albillos, Arik J. Hone, Tino Dyhring, Gordon, Thomas J., Albillos Martínez, María Almudena, McIntosh, J. Michael, Gajewiak, Joanna, Thomas J. Gordon, Sean Christensen, Dyhring, Tino, Joanna Gajewiak, J. Michael McIntosh   +15 more
core   +3 more sources

Cyclization of the Analgesic α‐Conotoxin Vc1.1 With a Non‐Natural Linker: Effects on Structure, Stability, and Bioactivity [PDF]

Journal of Peptide Science, Volume 31, Issue 6, June 2025.
This study cyclized conotoxin Vc1.1 using polyethylene glycol (PEG) linkers of different lengths and demonstrates that linker length modulates the peptide's helicity, thereby influencing its biological activity and stability. ABSTRACT α‐Conotoxin Vc1.1 is a disulfide‐rich peptide and a promising drug candidate for treating neuropathic and chronic pain.
Yuhui Zhang, Han Shen Tae, David J. Adams, Thomas Durek, David J. Craik   +4 more
wiley   +3 more sources

Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets [PDF]

Mar Drugs, 2019
Nicotinic acetylcholine receptors (nAChRs) are associated with various cancers, but the relation between nAChRs and cervical cancer remains unclear. Therefore, this study investigated the differential expression of nAChR subunits in human cervical cancer
Yiqiao Liu, Jiang Qian, Sulan Luo, Zhihua Sun, Dongting Zhangsun   +4 more
core   +3 more sources

Head-to-Tail Cyclization of α-Conotoxin TxID Leads to Enhanced Stability in Serum

GAZI UNIVERSITY JOURNAL OF SCIENCE, 2023
<p>Peptide biomolecules have important bioactivities and hence their use in drug design and development studies has increased in recent years. Conotoxins are natural peptides that obtained from cone snail venoms and have the potential to be used ...
Muharrem AKCAN, Nurcan BİÇEN KARAKOÇ, Akcan, Muharrem, Bicen Karakoc, Nurcan   +3 more
core   +2 more sources

Computational Design of α‐Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes [PDF]

Chemistry – A European Journal, Volume 30, Issue 7, February 1, 2024.
FoldX was benchmarked as the best energy prediction method, and seven accurate molecular models of α‐conotoxin/nAChRs were developed as surrogates for the experimental complexes. The combined use of FoldX and these molecular models emerged as an effective approach to predict α‐conotoxins with improved pharmaceutical properties.
Xiaosa Wu, Arik J. Hone, Yen‐Hua Huang, Richard J. Clark, J. Michael McIntosh, Quentin Kaas, David J. Craik   +6 more
wiley   +2 more sources

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity [PDF]

Front Pharmacol
Background and Purpose Nicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions.
Wen Wang, Meiting Wang, Huanbai Wang, Weifeng Xu, Conggang Wang, Jie Pei, Xiaodan Li, Dongting Zhangsun   +7 more
semanticscholar   +2 more sources

Single Amino Acid Substitution in Loop1 Switches the Selectivity of α-Conotoxin RegIIA towards the α7 Nicotinic Acetylcholine Receptor [PDF]

Mar Drugs
α-Conotoxins are disulfide-rich peptides obtained from the venom of cone snails, which are considered potential molecular probes and drug leads for nAChR-related disorders.
Jinpeng Yu, Junjie Xie, Yuting Ma, Pengcheng Wei, Panpan Zhang, Zepei Tang, Xiaopeng Zhu, Dongting Zhangsun, S. Luo   +8 more
semanticscholar   +2 more sources

Molecular determinants of the selectivity and potency of α-conotoxin Vc1.1 for human nicotinic acetylcholine receptors [PDF]

J Biol Chem
The α-conotoxins (α-Ctxs) are short, disulfide-rich peptides derived from the venom of the Conus marine snails, primarily acting as antagonists of nicotinic acetylcholine receptors (nAChRs).
Han-Shen Tae, Andrew Hung, Richard J. Clark, David J. Adams   +3 more
semanticscholar   +2 more sources

Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism

The FASEB Journal, 2023
This study was undertaken to identify and characterize the first ligands capable of selectively identifying nicotinic acetylcholine receptors containing α7 and β2 subunits (α7β2‐nAChR subtype). Basal forebrain cholinergic neurons express α7β2‐nAChR. Here,
Andrew A. George, Sabin J. John, L. Lucero, J. Eaton, Ekta Jaiswal, Sean B. Christensen, J. Gajewiak, M. Watkins, Yiwei Cao, Baldomero M Olivera, Wonpil Im, J. M. McIntosh, P. Whiteaker   +12 more
semanticscholar   +1 more source

α-Conotoxin recombinant protein ImI-AFP3 efficiently inhibits the growth and migration of lung cancer cells.

Protein Expression and Purification, 2023
α-Conotoxin ImI is a selective antagonist of alpha7 nicotinic acetylcholine receptor (α7 nAChR) that is involved in cancer development. Human alpha fetoprotein domain 3 (AFP3) is a prototype of anticancer agents.
Xiaobing Chen, Zijuan Zou, Wei Li, Xu Dong, Yi Chen, Yan Lu, Mingyue Zhu, Mengsen Li, Bo Lin   +8 more
semanticscholar   +1 more source