Results 31 to 40 of about 1,038 (93)

Stapling Cysteine[2,4] Disulfide Bond of α-Conotoxin LsIA and Its Potential in Target Delivery

Marine Drugs
α-Conotoxins, as selective nAChR antagonists, can be valuable tools for targeted drug delivery and fluorescent labeling, while conotoxin-drug or conotoxin-fluorescent conjugates through the disulfide bond are rarely reported.
Xin Sun, Jiangnan Hu, Maomao Ren, Hong-Tai Chang, Dongting Zhangsun, Baojian Zhang, Shuai Dong   +6 more
semanticscholar   +1 more source

Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus

Marine Drugs
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating ...
Jorge L B Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, I. B. Ramiro, J. Imperial, Lee S. Leavitt, J. Phan, Fernando A. Fisher, M. Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. M. McIntosh, V. Vasconcelos, Baldomero M Olivera, J. Gajewiak   +19 more
semanticscholar   +1 more source

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

Marine Drugs
α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions.
Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J. Adams, Ri-lei Yu   +7 more
semanticscholar   +1 more source

What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. [PDF]

J Med Chem, 2023
Straub CJ, Rusali LE, Kremiller KM, Riley AP.   +3 more
europepmc   +1 more source

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications. [PDF]

Biomolecules, 2022
Kasheverov I, Kudryavtsev D, Shelukhina I, Nikolaev G, Utkin Y, Tsetlin V.   +5 more
europepmc   +1 more source

Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors. [PDF]

Molecules, 2021
Bekbossynova A, Zharylgap A, Filchakova O.   +2 more
europepmc   +1 more source

From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR. [PDF]

Mar Drugs, 2021
Pan S, Fan Y, Zhu X, Xue Y, Luo S, Wang X.   +5 more
europepmc   +1 more source

A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy. [PDF]

Mar Drugs, 2022
Wang L, Wu X, Zhu X, Zhangsun D, Wu Y, Luo S.   +5 more
europepmc   +1 more source

Cross Talk between α7 and α3β4 Nicotinic Receptors Prevents Their Desensitization in Human Chromaffin Cells. [PDF]

J Neurosci, 2022
Jiménez-Pompa A, Sanz-Lázaro S, Omodolor RE, Medina-Polo J, González-Enguita C, Blázquez J, McIntosh JM, Albillos A.   +7 more
europepmc   +1 more source

Characterization of an α 4/7-Conotoxin LvIF from Conus lividus That Selectively Blocks α3β2 Nicotinic Acetylcholine Receptor. [PDF]

Mar Drugs, 2021
Guo M, Yu J, Zhu X, Zhangsun D, Luo S.
europepmc   +1 more source