Results 31 to 40 of about 917,242 (94)

α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR

, 2006
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits assemble to form the α9α10 nAChR subtype. This receptor is believed to mediate cholinergic synaptic transmission between efferent olivocochlear fibers and the hair cells of the cochlea.
McIntosh, J. Michael, Watkins, Maren, Elgoyhen, Ana Belen, Haberlandt, Christian, Gomez Casati, Maria Eugenia, Ellison, Michael, Olivera, Baldomero M.   +6 more
core   +1 more source

Enhancing Stability and Albumin Binding Efficiency of α‑Conotoxin GI through Fatty Acid Modification

α-Conotoxin GI is a competitive blocker of muscle-type acetylcholine receptors and holds the potential for being developed as a molecular probe or a lead compound for drug discovery.
Quankuo He (17398282), Jianying Dong (14979244), Yuanyuan Lian (8364879), Panpan Qi (3255048), Junjie Zhang (355622), Sulan Luo (277905), Ting Xie (191025), Dongting Zhangsun (277907), Yong Wu (165587)   +8 more
core   +1 more source

α-Conotoxin MII Blocks Nicotine-Stimulated Dopamine Release in Rat Striatal Synaptosomes

, 1997
Activation of presynaptic nicotinic acetylcholine receptors (nAChRs) can induce the release of neurotransmitters such as dopamine and norepinephrine in the CNS.
Jennifer M. Kulak, Baldomero M. Olivera, Thu A. Nguyen, J. Michael McIntosh   +3 more
core   +1 more source

Molecular docking study on the α3β2 neuronal nicotinic acetylcholine receptor complexed with α-Conotoxin GIC [PDF]

, 2012
Nicotinic acetylcholine receptors (nAChRs) are a diverse familyof homo- or heteropentameric ligand-gated ion channels.Understanding the physiological role of each nAChR subtypeand the key residues responsible for normal and pathologicalstates is ...
Do-Hyoung Kim, D H Kim, Kyou Hoon Han, Si-Hyung Lee, Si Hyoung Lee, Chewook Lee, Kyou-Hoon Han   +6 more
core   +1 more source

Stapling Cysteine[2,4] Disulfide Bond of α-Conotoxin LsIA and Its Potential in Target Delivery

α-Conotoxins, as selective nAChR antagonists, can be valuable tools for targeted drug delivery and fluorescent labeling, while conotoxin-drug or conotoxin-fluorescent conjugates through the disulfide bond are rarely reported.
Baojian Zhang, Xin Sun, Hong Chang, Jiangnan Hu, Maomao Ren, Dongting Zhangsun, Shuai Dong   +6 more
core   +1 more source

Structural Basis for α-Conotoxin Potency and Selectivity [PDF]

, 2009
Parkinson\u27s disease is a debilitating movement disorder characterized by altered levels of α6β2* nicotinic acetylcholine receptors (nAChRs) localized on presynaptic striatal catecholaminergic neurons.
Narver, Andrew, Eidemiller, Seth, McDougal, Owen M., Turner, Matthew, Martin, Bryan, Marshall, Joshua, Cornell, Kenneth A.   +6 more
core   +1 more source

Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor

, 2021
Conotoxins are marine peptide toxins from marine cone snails. The α-conotoxin RegIIA can selectively act on human (h) α3β4 nicotinic acetylcholine receptor (nAChR), and is an important lead for drug development.
Liang Xue (174224), Tao Jiang (28401), Han Shen Tae (20023188), Rilei Yu (228408), Meiling Zheng (4610461)   +4 more
core   +1 more source

α-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as α3β2 and α7 nicotinic acetylcholine receptors

, 2006
The molluskan acetylcholine-binding protein (AChBP) is a homolog of the extracellular binding domain of the pentameric ligand-gated ion channel family. AChBP most closely resembles the α-subunit of nicotinic acetylcholine receptors and in particular the ...
I Tsigelny, K Y Ho, Kyou Hoon Han, C Dowell, T T Talley, J M McIntosh, S B Christensen, B M Olivera, P Taylor   +8 more
core   +1 more source

NMR structure determination of α-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold

, 2006
We have determined a high-resolution three-dimensional structure of α-conotoxin BuIA, a 13-residue peptide toxin isolated from Conus bullatus. Despite its unusual 4/4 disulfide bond layout α-conotoxin BuIA exhibits strong antagonistic activity at α6 ...
Do-heyoung Kim, Seung-Wook Chi, Kyou Hoon Han, J M McIntosh, B M Olivera   +4 more
core   +1 more source

NMR solution conformation of and antitoxic analogue of α-conotoxin GI: identification of a common nicotinic acetylcholine receptor α₁-subunit binding surface for small ligans and α-conotoxins

, 1999
The three-dimensional solution conformation of an 11-residue antitoxic analogue of α-conotoxin GI, des-Glu1-[Cys3Ala]-des-Cys13-conotoxin GI (CANPACGRHYS-NH2, designated 'GI-15' henceforth), has been determined using two-dimensional 1H NMR spectroscopy ...
K Hun Mok, Kyou Hoon Han
core   +1 more source