Results 111 to 120 of about 10,698 (157)

Peptides containing SARS-CoV-2 spike-protein residues are antagonists of α7 and α9α10 nAChRs and modulate interleukin-1β release from human monocytic THP-1 cells. [PDF]

J Biol Chem
Hone AJ, Richter K, Riaz Z, Wakkuri J, Tekarli B, Gajewiak J, Grau V, McIntosh JM.   +7 more
europepmc   +1 more source

From marine predator to pharmacology: Conotoxin diversity, discovery, and therapeutic potential. [PDF]

Zool Res
Mao KL, Fu JX, Chen J, Liao YL, Huang ML, Chen Z, Lin LM, Shi Q, Gao BM.   +8 more
europepmc   +1 more source

The Functional Topology of Phenylpiperazinium Agonists and Antagonists on the Nicotinic Acetylcholine Receptor Landscape: Pointing the Way for Future Therapeutic Management of Inflammation and Neuropathic Pain. [PDF]

ACS Chem Neurosci
Andleeb H, Gulsevin A, Papke RL.
europepmc   +1 more source

A deep learning framework (CreoPep) for target-specific design and optimization of conotoxin peptides. [PDF]

Commun Chem
Ge C, Tae HS, Lu L, Zhang Z, Huang Z, An B, Wang Y, Jiang T, Cai W, Chang S, Adams DJ, Yu R.   +11 more
europepmc   +1 more source

Single Amino Acid Substitution in Loop1 Switches the Selectivity of α-Conotoxin RegIIA towards the α7 Nicotinic Acetylcholine Receptor. [PDF]

Mar Drugs
Yu J, Xie J, Ma Y, Wei P, Zhang P, Tang Z, Zhu X, Zhangsun D, Luo S.   +8 more
europepmc   +1 more source

Understanding varenicline function via key receptor and ligand interactions.

Cell Rep Phys Sci
Aiken SG, Fiorito D, Harper M, Pikus G, Underhill J, Murray J, Rawlinson J, O'Donoghue AC, Gotti C, Lummis SCR, Minguez Viñas T, Viscarra F, Bermudez I, Gallagher T, Oliveira ASF.   +14 more
europepmc   +1 more source

Convergence is not correctness: context-dependent performance of enhanced-sampling methods across biological complexity. [PDF]

Nat Commun
Kang C, Chen CG, Tang C, Arredondo SC, Zhou M, Fu H, Yang L, Gumbart JC, Fakharzadeh A, Moradi M, Chen H, Sun R, Harris J, Roux B, Chipot C.   +14 more
europepmc   +1 more source

Structural insights into the progressive recovery of α7 nicotinic acetylcholine receptor from nicotine-induced desensitization. [PDF]

Sci Adv
Liu S, Chen H, Zhu X, Ye F, Zhao Y, Qin J, Zheng Y, Wang X, Zhang L, Chen H, Li X, Mu W, Fu Y, Luo C, Hou H, Bai C, Liu L, Tian C.   +17 more
europepmc   +1 more source

Discriminative stimulus and locomotor activity profiles of nicotine and varenicline. [PDF]

Pharmacol Biochem Behav
Kusi-Boadum NK, Taylor CM, Shetty RA, Sumien N, Forster MJ.   +4 more
europepmc   +1 more source

Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition. [PDF]

Nat Commun
Su J, Yu Z, Yin Z, Zhang Z, Zhao J, Meng Y, Li R, Gao Y, Zhang H, Yu R, Zhao Y.   +10 more
europepmc   +1 more source