Results 111 to 120 of about 1,665 (158)

The Functional Topology of Phenylpiperazinium Agonists and Antagonists on the Nicotinic Acetylcholine Receptor Landscape: Pointing the Way for Future Therapeutic Management of Inflammation and Neuropathic Pain. [PDF]

ACS Chem Neurosci
Andleeb H, Gulsevin A, Papke RL.
europepmc   +1 more source

Modeling Nicotine, AT-1001, and Varenicline at the α3β4 Nicotine Acetylcholine Receptor

The escalating global prevalence of nicotine addiction, particularly among younger populations, has been linked to the increasing use of e-cigarettes, commonly known as vapes.
Madan, Japji, Khandai, Mourya, Cheong, Andersen   +2 more
core  

Structural insights into the progressive recovery of α7 nicotinic acetylcholine receptor from nicotine-induced desensitization. [PDF]

Sci Adv
Liu S, Chen H, Zhu X, Ye F, Zhao Y, Qin J, Zheng Y, Wang X, Zhang L, Chen H, Li X, Mu W, Fu Y, Luo C, Hou H, Bai C, Liu L, Tian C.   +17 more
europepmc   +1 more source

Single Amino Acid Substitution in Loop1 Switches the Selectivity of α-Conotoxin RegIIA towards the α7 Nicotinic Acetylcholine Receptor. [PDF]

Mar Drugs
Yu J, Xie J, Ma Y, Wei P, Zhang P, Tang Z, Zhu X, Zhangsun D, Luo S.   +8 more
europepmc   +1 more source

Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition. [PDF]

Nat Commun
Su J, Yu Z, Yin Z, Zhang Z, Zhao J, Meng Y, Li R, Gao Y, Zhang H, Yu R, Zhao Y.   +10 more
europepmc   +1 more source

Understanding varenicline function via key receptor and ligand interactions.

Cell Rep Phys Sci
Aiken SG, Fiorito D, Harper M, Pikus G, Underhill J, Murray J, Rawlinson J, O'Donoghue AC, Gotti C, Lummis SCR, Minguez Viñas T, Viscarra F, Bermudez I, Gallagher T, Oliveira ASF.   +14 more
europepmc   +1 more source

Chimeric Approach to Identify Molecular Determinants of Nicotinic Acetylcholine Receptors. [PDF]

Int J Mol Sci
Sapkota P, Akaberi SM, Ghimire B, Sharma K.   +3 more
europepmc   +1 more source

Stereoisomers of Chiral Methyl-Substituted Symmetric and Asymmetric Aryl Piperazinium Compounds Exhibit Distinct Selectivity for α9 and α7 Nicotinic Acetylcholine Receptors. [PDF]

ACS Chem Neurosci
Andleeb H, Papke RL, Richter K, Grau V, Hone AJ, Kerr A, McIntosh JM, Stokes C, Thakur GA.   +8 more
europepmc   +1 more source

The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets. [PDF]

Mol Cancer
Zhang C, Guo X, Wang Y, Zhang S, Wang Z.
europepmc   +1 more source

Peripheral Parasympathetic Networks in Pain: A Systems-Level Review of Mechanisms and Modulations. [PDF]

Cell Mol Neurobiol
Yang R, Jia S, Li Y, Yang H, Han Z, Liang L, Huang F, Fan W.   +7 more
europepmc   +1 more source