Results 41 to 50 of about 10,698 (157)

Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID

Marine Drugs, 2023
α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively.
Jianying Dong, Panpan Zhang, Junjie Xie, Ting Xie, Xiaopeng Zhu, Dongting Zhangsun, Jinpeng Yu, Sulan Luo   +7 more
doaj   +1 more source

Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors.

PLoS ONE, 2011
Acetylcholine-based neurotransmission is regulated by cationic, ligand-gated ion channels called nicotinic acetylcholine receptors (nAChRs). These receptors have been linked to numerous neurological diseases and disorders such as Alzheimer's disease ...
Ryan E Pavlovicz, Brandon J Henderson, Andrew B Bonnell, R Thomas Boyd, Dennis B McKay, Chenglong Li   +5 more
doaj   +1 more source

Review: “The Disappointment Dilemma: Short‐ and Long‐Term Learning From Negative Outcomes”

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
The habenula routes negative‐outcome signals to VTA, RMTg, and IPN to shape aversive learning and motivation. The lateral habenula encodes acute negative prediction errors to rapidly adapt behavior to threat, fear, and avoidance. The medial habenula integrates repeated stress, drug, and aversive experiences into long‐term negative mood and expectations.
Ines Ibañez‐Tallon, Susanna Molas, Christophe D. Proulx, Joaquin Piriz, Edgar Soria‐Gómez   +4 more
wiley   +1 more source

Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins

Marine Drugs, 2023
Elevenins are peptides found in a range of organisms, including arthropods, annelids, nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single conserved disulfide bond.
Bankala Krishnarjuna, Punnepalli Sunanda, Jeffrey Seow, Han-Shen Tae, Samuel D. Robinson, Alessia Belgi, Andrea J. Robinson, Helena Safavi-Hemami, David J. Adams, Raymond S. Norton   +9 more
doaj   +1 more source

Towards Mechanism‐Informed Treatments for Mental Health

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Neuropsychiatric disorders impose a major global health burden, and current treatments, which historically mostly targeted dopamine and serotonin dysfunctions, often provide only partial, symptomatic relief. This review highlights emerging evidence that additional neuromodulator systems, including acetylcholine, norepinephrine, and endocannabinoids ...
Iker Bengoetxea de Tena, Farhanah Nabilah Sallie, Arvie Rodriguez Abiero, Beatrice Rizzi, Leandro Gabriel Champarini, Elisa Corti, Gianluca Masella, Ariel L. Dunn, Luisa Bandeira Binder, Tyler J. Wenzel, Agustin I. Robles, Roberta G. Anversa, Cécilia Tremblay, Aliance Romain Fokoua, Randriely Merscher Sobreira de Lima, Mateus D'Ávila, Trang T. T. Truong, Jessica C. Pierce, Rui S. Rodrigues, Luis Dinamarca‐Villarroel, Felipe Borges Almeida, Aino‐Kaisa Piironen, Andrey F. L. Aguiar, Andrés M. Jaramillo, Lucas Santos, Anja de Lange, David J. Nutt, Andrew J. Lawrence   +27 more
wiley   +1 more source

Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes

Marine Drugs, 2015
In the present study, we synthesized and, structurally and functionally characterized a novel α4/7-conotoxin Mr1.7 (PECCTHPACHVSHPELC-NH2), which was previously identified by cDNA libraries from Conus marmoreus in our lab.
Shuo Wang, Cong Zhao, Zhuguo Liu, Xuesong Wang, Na Liu, Weihong Du, Qiuyun Dai   +6 more
doaj   +1 more source

Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids

Frontiers in Pharmacology, 2022
Alkaloids that target nicotinic acetylcholine receptors (nAChR) are of great interest because of the critical role they play in mood and anxiety. However, understanding of the neuropharmacological effects of nicotinic alkaloids, such as cotinine and ...
Omar Alijevic, Oihane Jaka, Ainhoa Alzualde, Diana Maradze, Wenhao Xia, Stefan Frentzel, Andrew N. Gifford, Manuel C. Peitsch, Julia Hoeng, Kyoko Koshibu   +9 more
doaj   +1 more source

Efficacy of combined varenicline and nicotine replacement therapy compared with varenicline or nicotine replacement therapy alone for smoking cessation: A systematic review and meta‐analysis

Addiction, Volume 121, Issue 3, Page 499-509, March 2026.
Abstract Aims To assess whether combining nicotine replacement therapy (NRT) with varenicline improves long‐term smoking cessation rates compared with varenicline or NRT alone. Method Systematic review and meta‐analysis of randomized controlled trials (RCTs) or quasi‐RCTs, conducted according to PRISMA guidelines.
Xinmei Zhou, Zhenxiao Huang, Qingqing Song, Xin Xia, Anqi Cheng, Zhao Liu, Min Wang, Tingfen Ji, Ailifeire Aihemaiti, Ying Xie, Yi Liu, Yuxin Shi, Shunyi Shi, Yingman Gao, Hang Liu, Jiahui He, Liang Zhao, Dan Xiao, Chen Wang   +18 more
wiley   +1 more source

Novel α3β4 Nicotinic Acetylcholine Receptor-Selective Ligands. Discovery, Structure−Activity Studies, and Pharmacological Evaluation

, 2016
Antagonist activity at the α3β4 nicotinic acetylcholine receptor (nAChR) is thought to contribute to the antiaddictive properties of several compounds. However, truly selective ligands for the α3β4 nAChR have not been available.
Lawrence Toll (375148), Faming Jiang (2248579), Nurulain Zaveri (2248576), Cris Olsen (2248585), Willma Polgar (2248582)   +4 more
core   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, Volume 46, Issue 1, Page 179-197, January 2026.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source