Results 41 to 50 of about 1,665 (158)

Molecular Regulation of Betulinic Acid on α3β4 Nicotinic Acetylcholine Receptors

Molecules, 2021
Betulinic acid (BA) is a major constituent of Zizyphus seeds that have been long used as therapeutic agents for sleep-related issues in Asia. BA is a pentacyclic triterpenoid. It also possesses various anti-cancer and anti-inflammatory effects.
Shinhui Lee, Woog Jung, Sanung Eom, Hye Duck Yeom, Heui-Dong Park, Junho H. Lee   +5 more
doaj   +1 more source

α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors

, 2017
α3β4 nAChRs have been implicated in various pathophysiological conditions. However, the expression profile of α3β4 nAChRs and α6/α3β4 nAChRs overlap in a variety of tissues.
Wu, Yong, Sulan Luo, Zhangsun, Manqi, Manqi Zhangsun, Zhangsun, Dongting, Peta J. Harvey, Craik, David J., McIntosh, J. Michael, Luo, Sulan, Zhu, Xiaopeng, Harvey, Peta J., Quentin Kaas, Kaas, Quentin, Xiaopeng Zhu, David J. Craik, Dongting Zhangsun, Yong Wu, J. Michael McIntosh   +17 more
core   +1 more source

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor

, 2017
Nicotinic acetylcholine receptors (nAChR) are therapeutic targets for a range of human diseases. α-Conotoxins are naturally occurring peptide antagonists of nAChRs that have been used as pharmacological probes and investigated as drug leads for nAChR ...
Paul F. Alewood, Nikita Abraham, Andreas Brust, Lotten Ragnarsson, Michael Healy, Richard J. Lewis   +5 more
core   +2 more sources

Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID

Marine Drugs, 2023
α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively.
Jianying Dong, Panpan Zhang, Junjie Xie, Ting Xie, Xiaopeng Zhu, Dongting Zhangsun, Jinpeng Yu, Sulan Luo   +7 more
doaj   +1 more source

Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors.

PLoS ONE, 2011
Acetylcholine-based neurotransmission is regulated by cationic, ligand-gated ion channels called nicotinic acetylcholine receptors (nAChRs). These receptors have been linked to numerous neurological diseases and disorders such as Alzheimer's disease ...
Ryan E Pavlovicz, Brandon J Henderson, Andrew B Bonnell, R Thomas Boyd, Dennis B McKay, Chenglong Li   +5 more
doaj   +1 more source

Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins

Marine Drugs, 2023
Elevenins are peptides found in a range of organisms, including arthropods, annelids, nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single conserved disulfide bond.
Bankala Krishnarjuna, Punnepalli Sunanda, Jeffrey Seow, Han-Shen Tae, Samuel D. Robinson, Alessia Belgi, Andrea J. Robinson, Helena Safavi-Hemami, David J. Adams, Raymond S. Norton   +9 more
doaj   +1 more source

Efficacy of combined varenicline and nicotine replacement therapy compared with varenicline or nicotine replacement therapy alone for smoking cessation: A systematic review and meta‐analysis

Addiction, Volume 121, Issue 3, Page 499-509, March 2026.
Abstract Aims To assess whether combining nicotine replacement therapy (NRT) with varenicline improves long‐term smoking cessation rates compared with varenicline or NRT alone. Method Systematic review and meta‐analysis of randomized controlled trials (RCTs) or quasi‐RCTs, conducted according to PRISMA guidelines.
Xinmei Zhou, Zhenxiao Huang, Qingqing Song, Xin Xia, Anqi Cheng, Zhao Liu, Min Wang, Tingfen Ji, Ailifeire Aihemaiti, Ying Xie, Yi Liu, Yuxin Shi, Shunyi Shi, Yingman Gao, Hang Liu, Jiahui He, Liang Zhao, Dan Xiao, Chen Wang   +18 more
wiley   +1 more source

Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes

Marine Drugs, 2015
In the present study, we synthesized and, structurally and functionally characterized a novel α4/7-conotoxin Mr1.7 (PECCTHPACHVSHPELC-NH2), which was previously identified by cDNA libraries from Conus marmoreus in our lab.
Shuo Wang, Cong Zhao, Zhuguo Liu, Xuesong Wang, Na Liu, Weihong Du, Qiuyun Dai   +6 more
doaj   +1 more source

Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids

Frontiers in Pharmacology, 2022
Alkaloids that target nicotinic acetylcholine receptors (nAChR) are of great interest because of the critical role they play in mood and anxiety. However, understanding of the neuropharmacological effects of nicotinic alkaloids, such as cotinine and ...
Omar Alijevic, Oihane Jaka, Ainhoa Alzualde, Diana Maradze, Wenhao Xia, Stefan Frentzel, Andrew N. Gifford, Manuel C. Peitsch, Julia Hoeng, Kyoko Koshibu   +9 more
doaj   +1 more source

Novel α3β4 Nicotinic Acetylcholine Receptor-Selective Ligands. Discovery, Structure−Activity Studies, and Pharmacological Evaluation

, 2016
Antagonist activity at the α3β4 nicotinic acetylcholine receptor (nAChR) is thought to contribute to the antiaddictive properties of several compounds. However, truly selective ligands for the α3β4 nAChR have not been available.
Lawrence Toll (375148), Faming Jiang (2248579), Nurulain Zaveri (2248576), Cris Olsen (2248585), Willma Polgar (2248582)   +4 more
core   +1 more source