Results 21 to 30 of about 1,798,291 (314)

Synthesis of activity evaluation of flavonoid derivatives as ɑ-glucosidase inhibitors

Frontiers in Chemistry, 2022
Six flavonoid derivatives were synthesized and tested for anti-α-glucosidase activities. All derivatives were confirmed using NMR and HRMS and exhibited excellent inhibitory effects on α-glucosidase.
Hua Zhu, Xin Zhong
doaj   +1 more source

Enhanced enzymatic activity and stability by in situ entrapment of α-Glucosidase within super porous p(HEMA) cryogels during synthesis

Biotechnology Reports, 2020
Here, poly(2-hydroxyethyl methacrylate) (p(HEMA)) cryogel were prepared in the presence 0.48, 0.96, and 1.92 mL of α-Glucosidase enzyme (0.06 Units/mL) solutions to obtain enzyme entrapped superporous p(HEMA) cryogels, donated as α-Glucosidase@p(HEMA)-1,
Sahin Demirci, Mehtap Sahiner, Selehattin Yilmaz, Erdener Karadag, Nurettin Sahiner   +4 more
doaj   +1 more source

Purification and characterization of two extracellular β-glucosidases fromAspergillus nidulans [PDF]

FEMS Microbiology Letters, 1992
Two β-glucosidases, P-I and P-II, were purified from the culture filtrate of Aspergillus nidulans. The Mr values of P-I and P-II were about 125 000 and 50 000, respectively. The isoelectric point, optimal pH and temperature, Michaelis constants for several substrates and inhibition constants for glucose and glucono-δ-lactone of each enzyme were ...
Ki-Sun Kwon, Hyung Gyoo Kang, Yung Chil Hah   +2 more
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Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase

Life, 2022
It is well known that carbohydrates are the main source of calories in most diets. However, by inhibiting carbohydrases, intake of calories is reduced and weight loss is improved.
Ina Ćorković, D. Gašo-Sokač, Anita Pichler, J. Šimunović, M. Kopjar   +4 more
semanticscholar   +1 more source

Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA derivatives were evaluated against α-glucosidase and α-amylase in vitro.
Xu-Yang Deng, Jun-Jie Ke, Ying-Ying Zheng, Dong-Li Li, Kun Zhang, Xi Zheng, Jing-Ying Wu, Zhuang Xiong, Pan-Pan Wu, Xue-Tao Xu   +9 more
doaj   +1 more source

Inhibitory Potential of α-Amylase, α-Glucosidase, and Pancreatic Lipase by a Formulation of Five Plant Extracts: TOTUM-63

International Journal of Molecular Sciences, 2023
Controlling post-prandial hyperglycemia and hyperlipidemia, particularly by regulating the activity of digestive enzymes, allows managing type 2 diabetes and obesity.
Quentin Haguet, F. Le Joubioux, V. Chavanelle, Hugo Groult, Nathan Schoonjans, Cédric Langhi, A. Michaux, Y. Otero, N. Boisseau, S. Peltier, P. Sirvent, T. Maugard   +11 more
semanticscholar   +1 more source

Inhibitory Mechanism of Engeletin Against α-Glucosidase

Natural Product Communications, 2021
The inhibitory mechanism of engeletin against α-glucosidase was investigated for the first time by fluorescence spectroscopy and molecular docking. The results showed that engeletin could inhibit α-glucosidase in a noncompetitive inhibition mode with a ...
Yunbo Li, Xiaoling Liu, Haoyu Zhou, Bo Li, Igor Kostiantinovich Mazurenko   +4 more
doaj   +1 more source

Extracellular α-glucosidase of an alkalophilic microorganism,Bacillussp. ATCC 21591 [PDF]

FEMS Microbiology Letters, 1983
Bacillus sp. ATCC 21591, an alkalophilic bacterium, produces 3 enzymes associated with degradation of starch-α-amylase, pullulanase and α-glucosidase. The latter reached a maximum after 24 h growth. Highest activities of α-glucosidase and pullulanase were obtained when the initial pH of the medium was 9.7 and although at pH 10.4 highest biomass was ...
C.T. Kelly, F. O'Reilly, W.M. Fogarty
openaire   +1 more source

Understanding phenolic acids inhibition of α-amylase and α-glucosidase and influence of reaction conditions.

Food Chemistry, 2021
Phenolic acids are involved in modulating the activity of starch digestive enzymes but remains unclear if their interaction with enzymes or starch is governing the inhibition.
Andrea Aleixandre, J. Gil, J. Sineiro, C. Rosell   +3 more
semanticscholar   +1 more source

Inhibition activity of α-glucosidase by infusion and ethanol extract of white tea and stevia combination [PDF]

Jurnal Sains Teh dan Kina, 2017
Ethanol extract of white tea and its stevia liquor was observed for α-glukosidase inhibition. The research was divided into some steps;  white tea and stevia combination hedonic sensory test, phytochemical identification, and α-glucosidase inhibition activity.
Elvi Trinoviani, Ai Kholisoh, Nisa Fitriani Ar-Rifa, Ardi Rustamsyah   +3 more
openaire   +1 more source