Results 131 to 140 of about 789,557 (313)

Sulfonamide chalcone as a new class of α-glucosidase inhibitors

, 2005
Chalcones 1-20, a new class of glycosidase inhibitors, were synthesized, and their glycosidase inhibitory activities were investigated. Non-aminochalcones 1-12 had no inhibitory activity, however, aminochalcones 13-20 had strong glycosidase (α ...
M S Yang, M J Curtis-Long, K H Park, J E Kang, Hyun Sun Lee, Hyung Won Ryu, W D Seo, J H Kim   +7 more
core   +1 more source

Extraction and Characterization of α -Amylase and α-Glucosidase Enzymes for Ethanol Preparation [PDF]

, 2020
In the research work, two enzymes (α -amylase and α-glucosidase) were extracted from germinated wheat grains and ungerminated flint corn by ammonium sulphate precipitation method for the bioethanol preparation.
Khin Moh Moh Hlaing, Dr, Ni Ni Aung, Dr, Aung Kyaw Moe, Mya Hnin Aye Khaing, Dr   +3 more
core  

Bio‐guided fractionation of (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Abelmoschus sagittifolius stands out as a valuable medicinal source for developing functional food targeting type 2 diabetes. This study investigated the α‐glucosidase inhibitory potential of an active fraction obtained from A. sagittifolius roots (ASR), enriched in (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid (OA), using both enzyme ...
Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan   +3 more
wiley   +1 more source

Rapidly screening of α-glucosidase inhibitors from Dioscorea opposita Thunb. peel based on rGO@Fe3O4 nanocomposites microreactor

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Present study aimed to immobilise the α-glucosidase on suitable supports to construct enzymatic microreactors and their subsequent applicability in efficient inhibitor screening from the Chinese Yam (Dioscorea opposita Thunb.) peel.
Songsong Zhang, Beibei Qiu, Jinhua Zhu, Weiping Hu, Fanyi Ma, M. Z. H. Khan, Xiuhua Liu   +6 more
doaj   +1 more source

Biochar‐Induced Shifts in Fungal Community Structure and Their Association With Soil Physical Properties in Degraded Soil From the Brazilian Semiarid

Land Degradation &Development, EarlyView.
ABSTRACT Soil degradation compromises ecosystem functioning. Biochar, a carbon‐rich amendment, has gained attention as a promising strategy to enhance soil structure and restore microbial balance. This study investigated the effects of two biochars, cashew bagasse biochar (CBB) and a co‐pyrolyzed biochar produced from sewage sludge and cashew pruning ...
João Marcos Rodrigues dos Santos, Arthur Prudêncio de Araujo Pereira, Kaio Gráculo Vieira Garcia, Ícaro Vasconcelos do Nascimento, Francisco Luan Almeida Barbosa, Tiago da Costa Dantas Moniz, Gilvanete da Silva Henrique, Murilo de Sousa Almeida, Vania Maria Maciel Melo, Mirian Cristina Gomes Costa, Helon Hébano de Freitas Sousa, Adriana Guirado Artur, Christiana de Fátima Bruce da Silva, Odair Pastor Ferreira, Antônio Gomes de Souza Filho, Erika Valente de Medeiros, Ademir Sergio Ferreira Araujo, Rafael Santiago da Costa, Jaedson Cláudio Anunciato Mota   +18 more
wiley   +1 more source

Benzonate derivatives of acetophenone as potent α-glucosidase inhibitors: synthesis, structure–activity relationship and mechanism

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
In this article, 23 compounds (6 and 7a–7v) were prepared and evaluated for their in vitro α-glucosidase inhibitory activity. The compounds 7d, 7f, 7i, 7n, 7o, 7r, 7s, 7u, and 7v displayed the α-glucosidase inhibition activity with IC50 values ranging ...
Wen-Jia Dan, Qiang Zhang, Fan Zhang, Wei-Wei Wang, Jin-Ming Gao   +4 more
doaj   +1 more source

MOESM1 of Identification and molecular characterization of a psychrophilic GH1 β-glucosidase from the subtropical soil microorganism Exiguobacterium sp. GXG2

, 2019
Additional file 1. Table S1. The results of homology modeling of BglG by multiple-template. Table S2. The evaluation of and multi-template model of BglG. Fig. S1. Functional screening of gene library. Fig. S2. Agarose gel electrophoresis of bglG gene. Fig. S3. The ramachandran plot of BglG multi-template model. Fig. S4.
Yin, Bangqiao, Gu, Hengsen, Mo, Xueyan, Xu, Yue, Yan, Bing, Li, Quanwen, Ou, Qian, Wu, Bo, Guo, Chen, Jiang, Chengjian   +9 more
openaire   +1 more source

Nitrogen Enrichment Enhances Soil Multifunctionality Through Distinct Drivers Across Urban, Suburban, and Rural Forests

Land Degradation &Development, EarlyView.
ABSTRACT The accelerating pace of urban expansion has profoundly reshaped urban–rural ecosystems, altering soil environments and impairing key ecological services. However, the combined impacts of urban expansion and atmospheric nitrogen (N) deposition on soil multifunctionality—the capacity to sustain multiple ecological processes—remain poorly ...
Xu Sun, Xiao Tao, Qingshui Yu, Zhuangzhuang Qian   +3 more
wiley   +1 more source

Characterising the selectivity of ER α-glucosidase inhibitors

, 2019
The endoplasmic reticulum (ER) contains both α-glucosidases and α-mannosidases which process the N-linked oligosaccharides of newly synthesised glycoproteins and thereby facilitate polypeptide folding and glycoprotein quality control.
High, Stephen; id_orcid, Roebuck, Quentin P, O'keefe, Sarah, Hirono, Shuichi, Nakagome, Izumi, Nash, Robert, Kato, Atsushi   +6 more
core   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu, Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D. Licht, John M. Allen, Kelvin P. Lee, Jingchuan Guo, Jiang Bian   +13 more
wiley   +1 more source