Results 311 to 320 of about 1,799,019 (357)

Flavonoids as potential agents in the management of type 2 diabetes through the modulation of α-amylase and α-glucosidase activity: a review

Critical reviews in food science and nutrition, 2021
Type 2 diabetes (T2D) is one of the most prevalent metabolic diseases worldwide and is characterized by increased postprandial hyperglycemia (PPHG). α-Amylase and α-glucosidase inhibitors have been shown to slow the release of glucose from starch and ...
C. Proença, D. Ribeiro, M. Freitas, E. Fernandes   +3 more
semanticscholar   +1 more source

A Computational Comparative study of α-Glucosidase enzyme Divergence

Journal of Applied Bioinformatics & Computational Biology, 2015
A Computational Comparative study of α-Glucosidase enzyme Divergence α-Glucosidase (α-Gls) enzymes have a crucial role in digestion of carbohydrates and biosynthesis of glycoproteins. Theses enzymes hydrolyze terminal glycosidic bonds and release α-glucose from the substrate chain. They are found in prokaryotic cells, plants and mammalian tissues such
Mohammad Hossein Mehraban, Younes Ghasemi   +1 more
openaire   +1 more source

Novel bioactive peptides from ginkgo biloba seed protein and evaluation of their α-glucosidase inhibition activity.

Food Chemistry, 2022
The inhibition of α-glucosidase activity has been recognized as an effective approach for treating type 2 diabetes mellitus (T2DM). In recent years, much emphasis has been placed on identifying peptides with α-glucosidase inhibitory activity and ...
Xiang Wang, Yejun Deng, Pujun Xie, Lujie Liu, Caihong Zhang, Jiang Cheng, Yang Zhang, Y. Liu, Lixin Huang, Jianxin Jiang   +9 more
semanticscholar   +1 more source

Effects of hydroxylation at C3' on the B ring and diglycosylation at C3 on the C ring on flavonols inhibition of α-glucosidase activity.

Food Chemistry, 2022
The structure-activity relationship and inhibitory mechanism of flavonols on α-glucosidase were studied by inhibition kinetics, multispectral study, and molecular docking.
Yajuan Qin, Xiaoai Chen, Fei Xu, Chunhe Gu, Kexue Zhu, Yanjun Zhang, Gang Wu, P. Wang, L. Tan   +8 more
semanticscholar   +1 more source

Lumi-HOF@Tb as Probes for Multiple Ratiometric Fluorescence and Chemiluminescence Sensing of α-Glucosidase.

Analytical Chemistry, 2022
The innovative assembly of luminescent hydrogen-bonded organic frameworks (HOFs) into multifunctional optical sensors is of great significance for developing advanced materials.
Haiyan Li, Shangqing Zhang, Mingli Chen, Jianhua Wang   +3 more
semanticscholar   +1 more source

Chemical structure and inhibition on α-glucosidase of polysaccharides from corn silk by fractional precipitation.

Carbohydrate Polymers, 2021
Aimed to explore different corn silk polysaccharide (CSP) fractions derived by ethanol precipitation on the physicochemical properties and biological activities, four fractions (CSP20, CSP40, CSP60, and CSP80) were obtained.
Yanan Jia, Zihan Xue, Yajie Wang, Yangpeng Lu, Ruilin Li, Nannan Li, Qirou Wang, Min Zhang, Min Zhang, Haixia Chen   +9 more
semanticscholar   +1 more source

Recent Advances of α-Glucosidase Inhibitors: A Comprehensive Review.

Current Topics in Medicinal Chemistry, 2022
BACKGROUND Diabetes mellitus (DM) is a critical health issue prevailing in nearly half a billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is caused due to insulin resistance and accounts for 90% of diabetes cases.
Ahsas Goyal, N. Agrawal, Manisha Sharma, Shikha Singh   +3 more
semanticscholar   +1 more source

Novel Bis-Schiff's base derivatives of 4-nitroacetophenone as potent α-glucosidase agents: Design, synthesis and in silico approach.

Bioorganic chemistry (Print), 2022
Bis-Schiff's base derivatives of 4-nitroacetophenone (1-18) were synthesized in good yields by reacting hydrazone of 4-nitroacetophenone with substituted aldehydes and ketones with catalytic amount of acetic acid.
A. Alam, Mumtaz Ali, A. Latif, N. Rehman, Samina Saher, Zainab, Faryal, Ajmal Khan, S. Ullah, Obaid Ullah, S. Halim, Fatma Sani, A. Al‐Harrasi, Manzoor Ahmad   +13 more
semanticscholar   +1 more source

The inhibitory mechanism of chlorogenic acid and its acylated derivatives on α-amylase and α-glucosidase.

Food Chemistry, 2021
Due to the poor lipophilicity of chlorogenic acid (CA), five CA derivatives (C2-CA, C4-CA, C6-CA, C8-CA, and C12-CA) with different lipophilicities were synthesized using acylation catalyzed by lipase in present study.
Shang-Sheng Wang, Yue Li, Dejian Huang, Shang-wei Chen, Yong-mei Xia, Song Zhu   +5 more
semanticscholar   +1 more source

Novel thiosemicarbazide-based β-carboline derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation.

European journal of medicinal chemistry
In the quest for potent α-glucosidase inhibitors to combat diabetes, a series of novel thiosemicarbazide-based β-carboline derivatives (CTL1∼36) were synthesized and evaluated.
Bingwen Liang, Di Xiao, Shao-Hua Wang, Xuetao Xu   +3 more
semanticscholar   +1 more source