Results 1 to 10 of about 45,012 (142)

A method for in vivo evaluation of α-glucosidase inhibition using Drosophila [PDF]

MethodsX, 2023
The development of α-glucosidase inhibitors is essential for the prevention of type II diabetes. Previous research has investigated in vitro inhibition using isolated α-glucosidase, which may not accurately reflect physical processes.
Nattapong Wongchum, Alongklod Tanomtong, Somchai Pinlaor, Chatmongkon Suwannapoom, Ananya Dechakhamphu   +4 more
doaj   +2 more sources

Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones [PDF]

Heliyon, 2022
The synthesized 3,3-di(indolyl)indolin-2-ones 1a-p showed desired higher α-glucosidase inhibitory activities and lower α-amylase inhibitory activities than standard drug acarbose.
Mardi Santoso, Li Lin Ong, Nur Pasca Aijijiyah, First Ambar Wati, Azminah Azminah, Rose Malina Annuur, Arif Fadlan, Zaher M.A. Judeh   +7 more
doaj   +2 more sources

New Perspectives on the Risks of Hydroxylated Polychlorinated Biphenyl (OH-PCB) Exposure: Intestinal Flora α-Glucosidase Inhibition [PDF]

Toxics
Polychlorinated biphenyls (PCBs) are a group of colorless and odorless environmental pollutants with a wide range of toxic effects. Some PCBs, especially less chlorinated ones, will rapidly undergo phase I metabolism after entering the body, and ...
Guoqiang Qin, Ruoyong Jia, Juntang Xue, Li Chen, Yang Li, Weiming Luo, Xiaomin Wu, Tianfeng An, Zhongze Fang   +8 more
doaj   +2 more sources

Synthesis and Molecular Docking Studies of Alkoxy- and Imidazole-Substituted Xanthones as α-Amylase and α-Glucosidase Inhibitors

Molecules, 2023
Current antidiabetic drugs have severe side effects, which may be minimized by new selective molecules that strongly inhibit α-glucosidase and weakly inhibit α-amylase.
Dolores G. Aguila-Muñoz, Gabriel Vázquez-Lira, Erika Sarmiento-Tlale, María C. Cruz-López, Fabiola E. Jiménez-Montejo, Víctor E. López y López, Carlos H. Escalante, Dulce Andrade-Pavón, Omar Gómez-García, Joaquín Tamariz, Aarón Mendieta-Moctezuma   +10 more
doaj   +1 more source

Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys [PDF]

Journal of Nephropharmacology, 2022
Introduction: In most ancient cultures, honey has been used for both nutritional and medical purposes. Objectives: In this research, phenolic extracts of four Iranian honeys were evaluated to determine the antioxidant potentials using DPPH (2,2-diphenyl ...
Mahmoodreza Moein, Soheila Moein, Fatemeh Farmani, Sahere Rozbehan, Zahra Sabahi   +4 more
doaj   +1 more source

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors

Frontiers in Chemistry, 2022
A series of benzylidene analogs of oleanolic acid 4a∼4s were synthesized and assessed for their α-glucosidase and α-amylase inhibitory activities. The results presented that all synthesized analogs exhibited excellent-to-moderate inhibitory effects on α ...
Jun-Jie Ke, Jing Lin, Xin Zhang, Xiao-Zheng Wu, Ying-Ying Zheng, Chun-Mei Hu, Yu Kang, Kun Zhang, Zhuang Xiong, Zhi-Qiang Ma   +9 more
doaj   +1 more source

In Vitro and In Silico Screening Analysis of Artabotrys sumatranus Leaf and Twig Extracts for α-Glucosidase Inhibition Activity and Its Relationship with Antioxidant Activity

Scientia Pharmaceutica, 2022
Artabotrys sumatranus is one of the Artabotrys species, which lives in Sumatera, Java, and Borneo in Indonesia. No research has been found related to its activity. The objective of this study was to explore the potential of A.
Dela Rosa, Berna Elya, Muhammad Hanafi, Alfi Khatib, Muhammad Imam Surya   +4 more
doaj   +1 more source

Effect of Black Tea and Black Tea Pomace Polyphenols on α-Glucosidase and α-Amylase Inhibition, Relevant to Type 2 Diabetes Prevention [PDF]

Frontiers in Nutrition, 2015
This study evaluates the potential mechanism of action and bioactivity of black tea and black tea pomace for type 2 diabetes prevention via inhibition of carbohydrate hydrolyzing enzymes. Black tea leaves were extracted in hot water and black tea pomace was extracted in 70% acetone.
Lisa eStriegel, Lisa eStriegel, Bouhee eKang, Sarah J. Pilkenton, Michael eRychlik, Emmanouil eApostolidis   +5 more
openaire   +4 more sources

Effects of lactic acid bacteria fermentated pollens on the inhibition of α-glucosidase

Shipin yu jixie, 2022
Objective: This study focus on improving the α-glucosidase inhibition rate of Camellia pollens. Methods: Using α-glucosidase inhibition rate as the index, the response surface methodology was used to optimize the effects of lactic acid bacteria ...
LUO Yue-peng, YANG Yuan-fan, YU Yang-jun, HE Jun-zhu, WU Ling   +4 more
doaj   +1 more source

Effects of Hibiscus sabdariffa Linn. fruit extracts on α-glucosidase enzyme, glucose diffusion and wound healing activities [PDF]

, 2017
Objective To provide in vitro evidence for antidiabetic activity through potential inhibition of α-glucosidase enzyme, glucose diffusion and enhancement in the wound healing using methanolic extract and fractions from Hibiscus sabdariffa Linn.
Bohari, S. P. M., Shadhan, R. M.
core   +5 more sources