Results 11 to 20 of about 22,484 (120)

Identification and Molecular Binding Mechanism of Novel α-Glucosidase Inhibitory Peptides from Hot-Pressed Peanut Meal Protein Hydrolysates

Foods, 2023
Hot-pressed peanut meal protein hydrolysates are rich in Arg residue, but there is a lack of research on their α-glucosidase inhibitory activity. In this study, different proteases were used to produce hot-pressed peanut meal protein hydrolysates (PMHs ...
Xinyu Yang, Dan Wang, Yangyong Dai, Luping Zhao, Wentao Wang, Xiuzhen Ding   +5 more
doaj   +1 more source

ANTI-DIABETIC POTENTIAL OF PEPTIDE FROM P. NIRURI REVEALS THROUGH CARBOHYDRATE HYDROLYZING ENZYME INHIBITION ASSAY [PDF]

Science Heritage Journal, 2019
Herb Phyllanthus niruri (P. niruri) is known to have various pharmacological functions including anti-diabetic properties. In this research, protein extracts from different plant parts (leave, fruit and stem) of P. niruri were investigated for their anti-
Noor Hasniza Md Zin, Ainul Mardhiah Mohd Nail   +1 more
doaj   +1 more source

Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA derivatives were evaluated against α-glucosidase and α-amylase in vitro.
Xu-Yang Deng, Jun-Jie Ke, Ying-Ying Zheng, Dong-Li Li, Kun Zhang, Xi Zheng, Jing-Ying Wu, Zhuang Xiong, Pan-Pan Wu, Xue-Tao Xu   +9 more
doaj   +1 more source

In Vitro Inhibitory Effects of Polyphenols from Flos sophorae immaturus on α-Glucosidase: Action Mechanism, Isothermal Titration Calorimetry and Molecular Docking Analysis

Foods, 2023
Flos sophorae immaturus (FSI) is considered to be a natural hypoglycemic product with the potential for a-glucosidase inhibitory activity. In this work, the polyphenols with α-glucosidase inhibition in FSI were identified, and then their potential ...
Yuhong Gong, Jun Li, Jinwei Li, Li Wang, Liuping Fan   +4 more
doaj   +1 more source

Synthesis and bioactivities evaluation of quinazolin-4(3H)-one derivatives as α-glucosidase inhibitors

BMC Chemistry, 2022
The development of new antidiabetes agents is necessary to obtain optimal glycemic control and overcome its complications. Different quinazolin-4(3H)-one bearing phenoxy-acetamide derivatives (7a–r) were designed and synthesized to develop α-glucosidase ...
Mahshid Moheb, Aida Iraji, Navid Dastyafteh, Minoo Khalili Ghomi, Milad Noori, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Fatemeh Rasekh, Bagher Larijani, Kamiar Zomorodian, Seyed Esmaeil Sadat-Ebrahimi, Mohammad Mahdavi   +11 more
doaj   +1 more source

α-Glucosidase and α-Amylase Inhibitory Potentials of Quinoline–1,3,4-oxadiazole Conjugates Bearing 1,2,3-Triazole with Antioxidant Activity, Kinetic Studies, and Computational Validation

Pharmaceuticals, 2022
Diabetes mellitus (DM) is a multifaceted metabolic disorder that remains a major threat to global health security. Sadly, the clinical relevance of available drugs is burdened with an upsurge in adverse effects; hence, inhibiting the carbohydrate ...
Nosipho Cele, Paul Awolade, Pule Seboletswe, Kolawole Olofinsan, Md. Shahidul Islam, Parvesh Singh   +5 more
doaj   +1 more source

α-/β-Glucosidase and α-Amylase Inhibitory Activities of Roselle (Hibiscus sabdariffa L.) Ethanol Extract

MCBS (Molecular and Cellular Biomedical Sciences), 2017
Background: Diabetes mellitus is a metabolic disease, characterized by hyperglycemia due to disturbance in both insulin secretion and function. One of theurapeutic approaches is to reduce blood glucose levels by inhbiting α-/β-glucosidase and α-amylase ...
Marisca Evalina Gondokesumo, Hanna Sari Widya Kusuma, Wahyu Widowati   +2 more
doaj   +1 more source

Inhibitory Effect of Naringin on α-Glucosidase and Its Mechanism

Shipin gongye ke-ji, 2022
To investigate the inhibitory activity and mechanism of naringin on α-glucosidase, the inhibition effect, type, and molecular mechanism of naringin on α-glucosidase were investigated by integrative analysis of enzyme kinetics, fluorescence spectroscopy ...
Xiangju ZHOU, Yuqin CHEN, Zhongping YIN, Qi LIANG, ZANG Jianwei, Daobang TANG, Jiguang CHEN   +6 more
doaj   +1 more source

α-Amylase and α-Glucosidase Inhibition by Brown Seaweed (Sargassum sp) Extracts

Research Journal of Life Science, 2014
Inhibition of intestinal α-amylase and α-glucosidase is an important strategy to control post-prandial hyperglycemia associated with diabetes mellitus.
Muhammad Firdaus, Asep Awaludin Prihanto
doaj   +1 more source

Inhibitory Effects of Myricetrin and Dihydromyricetin toward α-Glucosidase and Pancreatic Lipase with Molecular Docking Analyses and Their Interaction

Journal of Food Quality, 2021
The aim of the current study was to evaluate the interaction effects of myricetrin and dihydromyricetin in inhibiting α-glucosidase and pancreatic lipase at different combination ratios and concentrations and to illuminate the underlying mechanisms of ...
Siyuan Mi, Jia Liu, Xiaojing Liu, Yishan Fu, Junjie Yi, Shengbao Cai   +5 more
doaj   +1 more source