Results 21 to 30 of about 22,484 (120)

Insight into the Inhibitory Mechanisms of Hesperidin on α-Glucosidase through Kinetics, Fluorescence Quenching, and Molecular Docking Studies

Foods, 2023
The α-glucosidase inhibitor is of interest to researchers due to its association with type-II diabetes treatment by suppressing postprandial hyperglycemia. Hesperidin is a major flavonoid in orange fruit with diverse biological properties.
Kumaravel Kaliaperumal, Linyan Zhang, Liangliang Gao, Qin Xiong, Yan Liang, Yueming Jiang, Jun Zhang   +6 more
doaj   +1 more source

Inhibitory Mechanism of Quercimeritrin as a Novel α-Glucosidase Selective Inhibitor

Foods, 2023
In this study, 12 flavonoid glycosides were selected based on virtual screening and the literature, and Quercimeritrin was selected as the best selective inhibitor of α-glucosidase through in vitro enzyme activity inhibition experiments.
Fengyu Guo, Jie An, Minlong Wang, Weibo Zhang, Chong Chen, Xueying Mao, Siyuan Liu, Pengjie Wang, Fazheng Ren   +8 more
doaj   +1 more source

Synthesis of Curcumin Derivatives (2.5-Bis((E)-4-Hydroxy-3-Methoxy Benzylidine) Cyclopenta-1-On) from Vanillin and Its Activity Test Against Α-Glucosidase Enzymes

Walisongo Journal of Chemistry, 2022
Synthesis of curcumin analogs (2.5-Bis((E)-4-Hydroxy-3-Methoxy Benzylidine) Cyclopenta-1-On) based on Claisen-Schmidt condensation using an acid catalyst and inhibition of glucosidase enzyme was carried out.
Rahma Diyan Martha, Danar Danar, Rini Retnosari   +2 more
doaj   +1 more source

Phytochemical Screening, Antioxidant, and Inhibition Activity of Against α-Amylase and α-Glucosidase

Dose-Response, 2022
Picrorhiza kurroa (P.K) usually familiar as kutki is a well-known plant in the Ayurvedic system of medicine due to its reported activities including antidiabetic, antibacterial, antioxidant, antitumor, anti-inflammatory, and hepatoprotective. The current
Jaweria Nisar, Syed Muhammad A. Shah, Muhammad Akram, Sultan Ayaz, Abid Rashid   +4 more
doaj   +1 more source

Inhibition of protein tyrosine phosphatase (PTP1B) and α-glucosidase by geranylated flavonoids from Paulownia tomentosa

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase are important targets to treat obesity and diabetes, due to their deep correlation with insulin and leptin signalling, and glucose regulation.
Yeong Hun Song, Zia Uddin, Young Min Jin, Zuopeng Li, Marcus John Curtis-Long, Kwang Dong Kim, Jung Keun Cho, Ki Hun Park   +7 more
doaj   +1 more source

Combined Inhibitory Effects of Procyanidins and Protocatechuic Acid on Starch Digestive Enzymes

Shipin gongye ke-ji
Starch is the main source of energy for the human body. Natural products such as procyanidin (PC) and protocatechuic acid (PCA) can reduce postp'ran'dial blood sugar by controlling the digestion of starch.
Jing ZHANG, Jiefan JIAO, Shaojun YUN, Cuiping FENG, Feier CHENG   +4 more
doaj   +1 more source

α- Glucosidase Inhibitory and Antioxidant Activities of Moluccella aucheri (Boiss.) Scheen Extracts [PDF]

Journal of Advanced Biomedical Sciences, 2021
Background & Objective: α-Glucosidase is one of the main enzymes in the intestinal absorption of carbohydrates. Inhibition of this enzyme can improve postprandial hyperglycemia in diabetic patients.
Mina Doorandishan, Morteza Gholami, Hossein Mirkhani, Pouneh Ebrahimi, Amir Reza Jassbi   +4 more
doaj  

Structure-Activity Relationships of N-Cinnamoyl and Hydroxycinnamoyl Amides on α-Glucosidase Inhibition

Journal of Chemistry, 2017
Currently, there is an increasing interest towards α-glucosidase inhibition of various diseases including diabetes mellitus type 2, cancer, HIV, and B- and C-type viral hepatitis.
Maya G. Chochkova, Petranka P. Petrova, Boyka M. Stoykova, Galya I. Ivanova, Martin Štícha, Gábor Dibó, Tsenka S. Milkova   +6 more
doaj   +1 more source

Uji Aktivitas Antidiabetes dari Ekstrak Metanol Buah Kiwi (Actinidia deliciosa) melalui Penghambatan Aktivitas α-Glukosidase

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2017
Diabetes melitus (DM) is defined as a chronic metabolic disease or disorder with multiple etiologies characterized by high blood sugar levels. One way to treat diabetes mellitus is inhibiting the α-glucosidase enzyme.
Okpri Meila, Noraini Noraini
doaj   +1 more source

Evaluation of cannabidiol’s inhibitory effect on alpha-glucosidase and its stability in simulated gastric and intestinal fluids

Journal of Cannabis Research, 2021
Objective Cannabidiol (CBD) has been reported to have anti-diabetic effects in pre-clinical and clinical studies but its inhibitory effects on α-glucosidase, a carbohydrate hydrolyzing enzyme, remain unknown. Herein, we evaluated CBD’s inhibitory effects
Hang Ma, Huifang Li, Chang Liu, Navindra P. Seeram   +3 more
doaj   +1 more source