Results 31 to 40 of about 22,484 (120)

Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting α-amylase, and α-glucosidase: synthesis, molecular docking, and ADMET studies

Journal of Enzyme Inhibition and Medicinal Chemistry
Inhibition of α-glucosidase and α-amylase are key tactics for managing blood glucose levels. Currently, stronger, and more accessible inhibitors are needed to treat diabetes.
Nirvana A. Gohar, Eman A. Fayed, Yousry A. Ammar, Ola A. Abu Ali, Ahmed Ragab, Amal M. Mahfoz, Moustafa S. Abusaif   +6 more
doaj   +1 more source

Benzonate derivatives of acetophenone as potent α-glucosidase inhibitors: synthesis, structure–activity relationship and mechanism

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
In this article, 23 compounds (6 and 7a–7v) were prepared and evaluated for their in vitro α-glucosidase inhibitory activity. The compounds 7d, 7f, 7i, 7n, 7o, 7r, 7s, 7u, and 7v displayed the α-glucosidase inhibition activity with IC50 values ranging ...
Wen-Jia Dan, Qiang Zhang, Fan Zhang, Wei-Wei Wang, Jin-Ming Gao   +4 more
doaj   +1 more source

Both Acidic pH Value and Binding Interactions of Tartaric Acid With α-Glucosidase Cause the Enzyme Inhibition: The Mechanism in α-Glucosidase Inhibition of Four Caffeic and Tartaric Acid Derivates

Frontiers in Nutrition, 2021
The inhibition mechanism of four caffeic and tartaric acid derivates, including caffeic acid (CA), tartaric acid (TA), caftaric acid (CFA) and chicoric acid (CHA) against α-glucosidase was characterized by substrate depletion, fluorescence quenching ...
Wenyue Li, Yi Song, Wanshu Sun, Xi Yang, Xuebo Liu, Lijun Sun   +5 more
doaj   +1 more source

Evaluation of the alpha-glucosidase and alpha-amylase inhibitory potential of the Costus speciosus (J. Koenig) Sm. harvested in Vietnam

Vietnam Journal of Science, Technology and Engineering
This study aimed to evaluate the inhibitory activity of α-glucosidase and α-amylase enzymes using aqueous and 40% ethanol extracts from the aerial parts of Costus speciosus harvested in Binh Phuoc province, tested in vitro.
Oanh Hoang Hua, Nu Thi
doaj   +1 more source

Optimization and Molecular Mechanism of Novel α-Glucosidase Inhibitory Peptides Derived from Camellia Seed Cake through Enzymatic Hydrolysis

Foods, 2023
In recent years, food-derived hypoglycemic peptides have received a lot of attention in the study of active peptides, but their anti-diabetic mechanism of action is not yet clear.
Yuanping Zhang, Fenghua Wu, Zhiping He, Xuezhi Fang, Xingquan Liu   +4 more
doaj   +1 more source

Competitive α-glucosidase inhibitors, dihydrobenzoxanthones, from the barks of Artocarpus elasticus

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
This study aimed to search the α-glucosidase inhibitors from the barks part of Artocarpus elasticus. The responsible compounds for α-glucosidase inhibition were found out as dihydrobenzoxanthones (1–4) and alkylated flavones (5–6). All compounds showed a
Janar Jenis, Aizhamal Baiseitova, Sang Hwa Yoon, Chanin Park, Jeong Yoon Kim, Zuo Peng Li, Keun Woo Lee, Ki Hun Park   +7 more
doaj   +1 more source

Anti-Diabetic Effects of Different Phenolic-Rich Fractions from Rhus Chinensis Mill. Fruits in vitro

eFood, 2021
This study investigated the inhibitory effects of the Ethanol Extract (EE), Free Phenolic (TF), Esterified Phenolic (TE) and Insoluble-bound Phenolic (TI) from Rhus chinensis Mill.
Xiaojing Liu, Yishan Fu, Qian Ma, Junjie Yi, Shengbao Cai   +4 more
doaj   +1 more source

In vitro study on the hypoglycemic potential of Nicotiana tabacum leaf extracts

Bangladesh Journal of Pharmacology, 2014
Inhibition of some carbohydrate metabolizing enzymes is one of the modes of action of antihyperglycemic agents. The aim of this study was to investigate the in vitro inhibition of α-amylase and α-glucosidase by extracts of N. tabacum leaf.
Mutiu Idowu Kazeem, Semawon Mauton Ogungbe, Gbemisola Morounke Saibu, Oluwaseyi Mayode Aboyade   +3 more
doaj  

Identification of highly potent α-glucosidase inhibitory and antioxidant constituents from Zizyphus rugosa bark: enzyme kinetic and molecular docking studies with active metabolites

Pharmaceutical Biology, 2017
Context: Previous studies have shown that extracts of Zizyphus rugosa Lam. (Rhamnaceae) bark contained phytoconstituents with antidiabetic potential to lower blood glucose levels in diabetic rats. However, there has been no report on the active compounds
Jirapast Sichaem, Thammarat Aree, Kiattisak Lugsanangarm, Santi Tip-pyang   +3 more
doaj   +1 more source

Antioxidant activity and α-glucosidase inhibitory activity of five banana pulp polyphenols

Shipin yu jixie
Objective: The purpose of this study was to compare the activity difference of polyphenols in banana pulp of different varieties and to provide scientific basis for the exploitation and utilization of banana pulp polyphenols.
RAN Jingfeng, CHEN Xiaoai, YI Cuiping, ZHANG Yanjun   +3 more
doaj   +1 more source