Results 41 to 50 of about 22,484 (120)

Docking Sulochrin and Its Derivative as α-Glucosidase Inhibitors of Saccharomyces cerevisiae

Indonesian Journal of Chemistry, 2017
Sulochrin known has activity as inhibitors of α-glucosidase enzyme. Interaction of sulochrin to active site of α-glucosidase enzyme from S. cerevisiae has studied by docking method.
Wening Lestari, Rizna Triana Dewi, Leonardus Broto Sugeng Kardono, Arry Yanuar   +3 more
doaj   +1 more source

A new route to the synthesis of 2-hydrazolyl-4-thiazolidinone hybrids, evaluation of α-glucosidase inhibitory activity and molecular modeling insights

Heliyon
One of the multifactorial worldwide health syndromes is diabetes mellitus which is increasing at a disturbing rate. The inhibition of α-glucosidase, an enzyme that catalyzes starch hydrolysis in the intestine, is one helpful therapeutic approach for ...
Saghi Sepehri, Ghazaleh Farhadi, Maryam Maghbul, Farough Nasiri, Mohammad Ali Faramarzi, Karim Mahnam, Somayeh Mojtabavi, Mohammad Mahdavi, Zhaleh Moharrami Oranj   +8 more
doaj   +1 more source

Chiral pyrimidinyl-piperazine carboxamide derivatives as potent yeast α-glucosidase inhibitors

Scientific Reports
α-Glucosidase is an important target in treating type 2 diabetes, and thus, the inhibition of this enzyme could delay sugar digestion and avoid postprandial hyperglycemia.
Noval Herfindo, Pirun Mikled, Neni Frimayanti, Thanyada Rungrotmongkol, Warinthorn Chavasiri   +4 more
doaj   +1 more source

Isolation, characterization, antidiabetic and antityrosinase potentials of compounds isolated from Anabasis Articulata

Applied Food Research
Herein, we report the isolation, characterization, in silico evaluation and biological potentials of four compounds (1–4) isolated from A. Articulata. All compounds (isoleteolin (2), hyperoside (3) and quercitrin (4)) demonstrated antioxidant properties;
Marwa Jan, Abdul Bari Shah, Fakhria A. Al-Joufi, Muhammad Zahoor, Muhammad Esa, Haroon ur Rashid, Naila Gulfam, Muhammad Saqib Shahzad, Haseena   +8 more
doaj   +1 more source

Effect of in vitro gastrointestinal digestion on the composition and bioactivity of anthocyanins in the fruits of cultivated Lycium ruthenicum Murray

CyTA - Journal of Food, 2019
The composition of anthocyanins in cultivated Lycium ruthenicum Murray (CLM) before and after in vitro gastrointestinal digestion was determined using an HPLC system coupled with an electrospray ionization-time of flight mass spectrometry.
Zi-Chao Wang, Nisar Tanzeela, Lijun Sun, Zhongxiang Fang, Yuzhen Yan, Dan Li, Huichun Xie, Huichun Wang, Yurong Guo   +8 more
doaj   +1 more source

Inhibitory Effect of Genistein on α-Glucosidase and Its Molecular Mechanism

Shipin gongye ke-ji
To investigate the inhibitory effects of genistein on α-glucosidase activity, the effects of genistein on starch digestion characteristics were determined by in vitro digestion assays. The type and molecular mechanism of inhibition were examined based on
Jianhui JIA, Boxin DOU, Man GAO, Chujia ZHANG, Ying LIU, Na ZHANG   +5 more
doaj   +1 more source

α-Glucosidase inhibition by green, white and oolong teas: in vitro activity and computational studies. [PDF]

J Enzyme Inhib Med Chem, 2023
Esposito F, Pala N, Carcelli M, Boateng ST, D'Aquila PS, Mariani A, Satta S, Chamcheu JC, Sechi M, Sanna V.   +9 more
europepmc   +1 more source

Phytochemical constituents of Hydrangea macrophylla var. acuminata leaves and their inhibitory activity against PTP1B and α-glucosidase

Journal of Enzyme Inhibition and Medicinal Chemistry
This study presents the first comprehensive phytochemical analysis of Hydrangea macrophylla var. acuminata leaves, resulting in the isolation of 41 secondary metabolites, including four new compounds: one phenolic (3) and three bis-iridoid glycosides (30–
Thi Ly Pham, Viet Phong Nguyen, Thi Thuy An Nguyen, Byung Sun Min, Jeong Ah Kim   +4 more
doaj   +1 more source

IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY

Vitae
Background: Momordica charantia is a vine, native to tropics and subtropics that has found use in herbal medicine. In Nigeria, the plant is locally used in the treatment of diabetes.
A. B. SALLAU, R. N. YAKUBU, S. M. ABDULLAHI, A. SALIHU, B. Y. BONIFACE   +4 more
doaj   +1 more source

Design, synthesis, and evaluation of triazolo[1,5-a]pyridines as novel and potent α‑glucosidase inhibitors

Scientific Reports
α-Glucosidase is a key enzyme responsible for controlling the blood glucose, making a pivotal target in the treatment of type 2 diabetes mellitus.
Fariba Peytam, Parham Foroumadi, Hayrettin Ozan Gulcan, Maryam Norouzbahari, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Fahimeh Ghasemi, Mohammadreza Torabi, Behnaz Bameri, Maliheh Barazandeh Tehrani, Loghman Firoozpour, Alireza Foroumadi   +11 more
doaj   +1 more source