Results 61 to 70 of about 45,106 (236)

Evaluation of the alpha-glucosidase and alpha-amylase inhibitory potential of the Costus speciosus (J. Koenig) Sm. harvested in Vietnam

Vietnam Journal of Science, Technology and Engineering
This study aimed to evaluate the inhibitory activity of α-glucosidase and α-amylase enzymes using aqueous and 40% ethanol extracts from the aerial parts of Costus speciosus harvested in Binh Phuoc province, tested in vitro.
Oanh Hoang Hua, Nu Thi
doaj   +1 more source

Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats [PDF]

, 2015
In the present study, a 50% ethanolic extract of Orthosiphon stamineus was tested for its α-glucosidase inhibitory activity. In vivo assays of the extract (containing 1.02%, 3.76%, and 3.03% of 3′hydroxy-5,6,7,4′-tetramethoxyflavone, sinensetin, and ...
Ahmad, Mariam, Asmawi, Mohd. Zaini, Lee, Fung Ang, Mohamed, Elsnoussi Ali, Mun, Fei Yam   +4 more
core   +4 more sources

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Anti-Diabetic Effects of Different Phenolic-Rich Fractions from Rhus Chinensis Mill. Fruits in vitro

eFood, 2021
This study investigated the inhibitory effects of the Ethanol Extract (EE), Free Phenolic (TF), Esterified Phenolic (TE) and Insoluble-bound Phenolic (TI) from Rhus chinensis Mill.
Xiaojing Liu, Yishan Fu, Qian Ma, Junjie Yi, Shengbao Cai   +4 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Competitive α-glucosidase inhibitors, dihydrobenzoxanthones, from the barks of Artocarpus elasticus

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
This study aimed to search the α-glucosidase inhibitors from the barks part of Artocarpus elasticus. The responsible compounds for α-glucosidase inhibition were found out as dihydrobenzoxanthones (1–4) and alkylated flavones (5–6). All compounds showed a
Janar Jenis, Aizhamal Baiseitova, Sang Hwa Yoon, Chanin Park, Jeong Yoon Kim, Zuo Peng Li, Keun Woo Lee, Ki Hun Park   +7 more
doaj   +1 more source

Targeting MGAT4A‐Mediated N‐Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion

Exploration, EarlyView.
ABSTRACT Glioblastoma (GBM) is the most aggressive type of primary brain tumor, and its invasive properties contribute significantly to incomplete surgical resection and tumor recurrence. Despite extensive clinical efforts to mitigate GBM invasion, targeted therapies against GBM stem cells (GSCs), which drive invasion, remain incompletely understood ...
Rui Niu, Meichen Liu, Qingshan Yang, Jinlong Yin   +3 more
wiley   +1 more source

In vitro study on the hypoglycemic potential of Nicotiana tabacum leaf extracts

Bangladesh Journal of Pharmacology, 2014
Inhibition of some carbohydrate metabolizing enzymes is one of the modes of action of antihyperglycemic agents. The aim of this study was to investigate the in vitro inhibition of α-amylase and α-glucosidase by extracts of N. tabacum leaf.
Mutiu Idowu Kazeem, Semawon Mauton Ogungbe, Gbemisola Morounke Saibu, Oluwaseyi Mayode Aboyade   +3 more
doaj  

Health promoting potential of herbal teas and tinctures from Artemisia campestris subsp maritima: from traditional remedies to prospective products [PDF]

, 2018
This work explored the biotechnological potential of the medicinal halophyte Artemisia campestris subsp. maritima (dune wormwood) as a source of health promoting commodities.
A Akrout, A Alam, A Atia, A Buhmann, A Djeridane, A Lopes, AA Jahid, AP Rauter, AS Ribeiro, B Boulanouar, B Saad, CG Pereira, CG Pereira, D Paepe De, DA Viegas, DR Nogueira, F Shahidi, H Akkari, H Riedel, H Sebai, I Dib, I Jallali, JF Sanz, JG Gruenwald, JMJ Vasconcelos, KM Valant-Vetschera, L Barreira, L Custódio, M Karamać, M Saoudi, M Sefi, MJ Rodrigues, MJ Rodrigues, MJ Rodrigues, MP Kähkönen, MTH Khan, N Balasundram, P Pohl, R Ksouri, RW Pero, S Kumar, S Saeidnia, SK Panigrahy, T Oki, T-S Chang, V Sindhi, W Megdiche-Ksouri, YI Kwon, Z Ghlissi   +48 more
core   +2 more sources

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source