Results 141 to 150 of about 965,280 (210)

Curcumin Therapy Reduces Iron Overload and Oxidative Stress in Beta-Thalassemia: Findings from a Meta-Analytic Study

The risk of anemia and iron overload is a global concern in beta (β)-thalassemia. The β-thalassemia primary treatment includes blood transfusion and iron chelation therapy; however, both are associated with risks such as anemia, iron depletion,
Perpetua Modjadji, Kabelo Mokgalaboni, Wendy N. Phoswa, Sogolo L. Lebelo   +3 more
core   +1 more source

Pharmacotherapy of Beta Thalassemia Major

, 2017
The aim of this thesis is to discuss the incidence, aetiology, clinical manifestation, diagnosis and pharmacological management of beta thalassemia major.
Kazemi Mohammadi, Seyedeh Maral
core  

α-Thalassemia among pediatric Nb S homozygotes

, 1987
The number of α globin genes have been documented among 255 active SS patients under the age of 15 years. Ascertainment in the area served by our clinical program is 84%. The common -3.7 Kb α+ -Thalassemia (Th) had a gene frequency of 0.17. The incidence
McKie, Kathleen Mood, Kutlar, Abdullah, McKie, Virgil C., Felice, Alex, Zhao, J., Twenty-ninth Annual Meeting of the American Society of Hematology   +5 more
core  

Screening for (-(SEA)) α-globin gene deletion in β-thalassemia carriers and prevention of hydrops fetalis

, 2000
In Southeast Asia, where thalassemia is prevalent, heterozygous carriers of both β-thalassemia mutation and the (-(SEA)) α-globin gene deletion are encountered.
Ma, ESK, Chan, GCF, Yu Lung Lau, Shau Yin Ha, Li Chong Chan, Chan, AYY   +5 more
core  

Successful gene therapy for transfusion-dependent α-thalassemia: a case report. [PDF]

Blood Adv
Yin X, Qian L, Dong G, Chen Y, Zhou Y, Yang B, Liao G, Sun H, Guo H, Zeng X, Zou H, Ye T, He J, Yao W, Ouyang W, Zhang X, Liu C.   +16 more
europepmc   +1 more source

Planting seeds of cure before birth in α-thalassemia major. [PDF]

Blood Adv
Rozmus J, Amid A.
europepmc   +1 more source

Molecular Spectrum of α-Thalassemia Mutations in Antalya, Türkiye and Their Relationship with Hematological Parameters. [PDF]

Genes (Basel)
Erkal Ö, Paksoy B.
europepmc   +1 more source

Appropriate whole genome amplification and pathogenic loci detection can improve the accuracy of preimplantation genetic diagnosis for deletional α-thalassemia. [PDF]

Front Endocrinol (Lausanne), 2023
Lan Y, Zhou H, He S, Shu J, Liang L, Wei H, Luo J, Wang C, Zhao X, Qiu Q, Huang P.   +10 more
europepmc   +1 more source

Application of short tandem repeats (STRs) in the preimplantation genetic diagnosis (PGD) of α-thalassemia

Objectives: α-thalassemia is an autosomal recessive monogenic blood disorder, affecting up to 5% of the world's population. The occurrence rate of the disease in Vietnam varies up to up to 51.5%, with high rate of mutation carriers, of couples consisting
Phuong Le Thi, Phuoc-Dung Nguyen, Nha Nguyen Thi, Van-Khanh Tran, Manh Ha Nguyen, Dang Thi Minh Nguyet, Hai Anh Tran, The-Hung Bui, Thinh Huy Tran, Thanh Van Ta, Nhat-Minh Dang-Tran, Vu Viet Ha Vuong   +11 more
core   +1 more source

In utero hematopoietic cell transplantation in fetuses with α-thalassemia major: a phase 1 clinical trial. [PDF]

Blood Adv
MacKenzie TC, Lianoglou BR, Gonzalez Velez J, Dvorak CC, Kharbanda S, Herzeg A, Canepa E, Kreger EM, Frascoli M, Sper R, Gupta AR, Leung J, Tang Q, Sinha R, Worthington AK, Gano D, Bakkour Coco S, Chafets D, Keller RL, Shimotake J, Lal A, Glenn OA, Moon-Grady AJ, Vichinsky E.   +23 more
europepmc   +1 more source