Results 121 to 130 of about 779,152 (196)
Co-inheritance of SCA and α-thalassemia and hematological indices.
, 2014 Co-inheritance of SCA and α-thalassemia and hematological indices.
Jeanne Ngogang (542273) +6 more
core +1 more source
Classification of α-thalassemia data using machine learning models [PDF]
Background: Around 7% of the global population has congenital hemoglobin disorders, with over 300,000 new cases of α-thalassemia annually. Diagnosis is costly and inaccurate in low-income regions, often relying on complete blood count (CBC) tests.
Kılıç, Deniz Kenan +14 more
core +1 more source
Hb SKMC and an unprecedented γδβ-thalassemia: first report from Iraq
HematologyBackground Thalassemias are genetic disorders of globin chain synthesis. In Iraq, β-thalassemia is more prevalent than α-thalassemia. This study identifies two unpredicted globin gene mutations, a rare α-globin gene mutation (Hb SKMC) and a novel γδβ ...
Rawand P. Shamoon +6 more
doaj +1 more source
, 2006 Haptoglobin (Hp) is an acute phase protein that removes free hemoglobin (Hb) released during hemolysis. Hp has also been shown to be toxic for malaria parasites. a+-Thalassemia is a hemoglobinopathy that results in subclinical hemolytic anemia.
Imrie, H +10 more
core
The risk of anemia and iron overload is a global concern in beta (β)-thalassemia. The β-thalassemia primary treatment includes blood transfusion and iron chelation therapy; however, both are associated with risks such as anemia, iron depletion,
Perpetua Modjadji +3 more
core +1 more source
Diagnosis of α-thalassemia using droplet digital PCR
Most α-thalassemia occurs due to a large deletion in the α-globin gene. Common α-thalassemia with known mutations, such as Southeast Asian (SEA) type is readily diagnosed by Gap-PCR.
Mori, Kentaro +9 more
core
Pharmacotherapy of Beta Thalassemia Major
, 2017 The aim of this thesis is to discuss the incidence, aetiology, clinical manifestation, diagnosis and pharmacological management of beta thalassemia major.
Kazemi Mohammadi, Seyedeh Maral
core
A novel α 0-thalassemia deletion in a Greek patient with HbH disease and β-thalassemia trait
, 2012 Objectives: To determine the molecular basis in a Greek child suspected of having HbH disease and β-thalassemia trait. Methods: Standard hematology, Hb electrophoresis, and HPLC. Multiplex ligation-dependent probe amplification (MLPA), direct sequencing,
Phylipsen, M. +10 more
core
Appropriate whole genome amplification and pathogenic loci detection can improve the accuracy of preimplantation genetic diagnosis for deletional α-thalassemia. [PDF]
Front Endocrinol (Lausanne), 2023 Lan Y +10 more
europepmc +1 more source
α-Thalassemia among pediatric Nb S homozygotes
, 1987 The number of α globin genes have been documented among 255 active SS patients under the age of 15 years. Ascertainment in the area served by our clinical program is 84%. The common -3.7 Kb α+ -Thalassemia (Th) had a gene frequency of 0.17. The incidence
McKie, Kathleen Mood +5 more
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