Expression of the α7 nicotinic acetylcholine receptor in human lung cells [PDF]
Respiratory Research, 2005 Background We and others have shown that one of the mechanisms of growth regulation of small cell lung cancer cell lines and cultured pulmonary neuroendocrine cells is by the binding of agonists to the α7 neuronal nicotinic acetylcholine receptor.
Schuller, Hildegard M. +8 more
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AAV.PHP.eB-based strategies for precise modulation of α7 nicotinic acetylcholine receptor in neurons and astrocytes in the adult mouse brain. [PDF]
Sci RepPrecise control of the α7 nicotinic acetylcholine receptor (α7-nAChR) in specific brain cell types is crucial for understanding its role in neural circuit function and disease.
Puliatti G +5 more
europepmc +3 more sources
Neuregulin upregulates microglial α7 nicotinic acetylcholine receptor expression in immortalized cell lines: implications for regulating neuroinflammation. [PDF]
PLoS ONE, 2013 Neuregulin, previously known as ARIA, is a signaling protein involved in cell survival, synaptic plasticity, cell communication and differentiation. Neuregulin has also been described as a potent inducer of acetylcholine receptor transcription in muscle ...
Malwina Mencel +5 more
core +2 more sources
Journal of Pharmacological Sciences, 2006 Nicotine inhibited interleukin (IL)-18 and -12 production in lipopolysaccharide (LPS)-stimulated monocytes, and the action of nicotine was antagonized by a non-selective and a selective α7 nicotinic acetylcholine receptor (α7-nAChR) antagonist ...
Tadashi Yoshino +5 more
core +2 more sources
Neuroinflammation Modulation via α7 Nicotinic Acetylcholine Receptor and Its Chaperone, RIC-3
Molecules, 2021 Nicotinic acetylcholine receptors (nAChRs) are widely expressed in or on various cell types and have diverse functions. In immune cells nAChRs regulate proliferation, differentiation and cytokine release.
Tehila Mizrachi +3 more
core +2 more sources
Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor. [PDF]
Cell Mol Life Sci, 2023 International audienceThe α7 nicotinic acetylcholine receptor (nAChR), a potential drug target for treating cognitive disorders, mediates communication between neuronal and non- neuronal cells. Although many competitive antagonists, agonists, and partial-
Li Q +10 more
europepmc +3 more sources
Vagus nerve stimulation is a potential treatment for ischemic stroke
Neural Regeneration Research, 2023 Microglia are the brain’s primary innate immune cells, and they are activated and affect pro-inflammatory phenotype or regulatory phenotype after ischemic stroke.
Yi-Lin Liu +4 more
doaj +1 more source
Acute lung injury in cholinergic-deficient mice supports anti-inflammatory role of α7 nicotinic acetylcholine receptor [PDF]
, 2021 (1) Background: The lung cholinergic pathway is important for controlling pulmonary inflammation in acute lung injury, a condition that is characterized by a sudden onset and intense inflammation.
Prado, Vivian F. +6 more
core +3 more sources
Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription. [PDF]
Cell Insight, 2022 Alpha7 nicotinic acetylcholine receptor (α7 nAChR), a hub of the cholinergic anti-inflammatory pathway (CAP), is required for the treatment of inflammatory diseases.
Wen J +8 more
europepmc +2 more sources
Journal of Pharmacological Sciences, 2022 We examined whether galantamine (GAL), a cholinesterase inhibitor and allosteric potentiating ligand for α7 nicotinic acetylcholine receptor (nAChR), had an impact on emotional abnormalities in forebrain-specific cholecystokinin receptor-2 overexpressed ...
Shota Tanase +6 more
doaj +1 more source