Speculation on How RIC-3 and Other Chaperones Facilitate α7 Nicotinic Receptor Folding and Assembly
Molecules, 2022 The process of how multimeric transmembrane proteins fold and assemble in the endoplasmic reticulum is not well understood. The alpha7 nicotinic receptor (α7 nAChR) is a good model for multimeric protein assembly since it has at least two independent and
Ralph H. Loring
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Anti-inflammation of spirocyclopiperazinium salt compound LXM-10 targeting α7 nAChR and M4 mAChR and inhibiting JAK2/STAT3 pathway in rats. [PDF]
PLoS ONE, 2013 The present study aims to investigate the therapeutic effects of LXM-10 by intragastric administration in both acute and chronic inflammatory models, and to explore the underlying molecular mechanisms.
Weiwei Zhang +5 more
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NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly
Cell Reports, 2020 Summary: The α7 nicotinic acetylcholine receptor participates in diverse aspects of brain physiology and disease. Neurons tightly control α7 assembly, which relies upon NACHO, an endoplasmic reticulum (ER)-localized integral membrane protein.
Hae-Jin Kweon +7 more
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α7 nicotinic acetylcholine receptor in memory processing [PDF]
, 2023 Information storage in the brain involves different memory types and stages that are processed by several brain regions. Cholinergic pathways through acetylcholine receptors actively participate on memory modulation, and their disfunction is associated ...
Jorge H. Medina +3 more
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Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor
Nature Communications, 2022 The intracellular domain (ICD) of Cys-loop receptors mediates many of their functions, but no complete structure of a Cys-loop receptor ICD is available to date.
Vasyl Bondarenko +12 more
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Stem Cell Research, 2019 The α7 nicotinic acetylcholine receptor has been extensively researched as a target for treatment of cognitive impairment in Alzheimer's disease and schizophrenia.
Hjalte M. Larsen +4 more
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Structure-Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids [PDF]
, 2012 This dissertation primarily describes structure-function studies of the nicotinic acetylcholine receptors (nAChRs). These studies use a combination of unnatural amino acid mutagenesis and electrophysiology to determine the specific molecular interactions
Puskar, Nyssa Leigh
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Upregulation of alpha 7 nicotinic receptors by acetylcholinesterase c-terminal peptides [PDF]
, 2009 Background: The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Bond, Cherie E. +14 more
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Journal of Pharmacological Sciences, 2004 GbaSM-4 cells, vascular smooth muscle cells (VSMCs) derived from brain basilar arteries, were shown to migrate toward d-nicotine by augmenting the actin cytoskeleton in their cell bodies and lamellipodia, and expression of nicotinic acetylcholine ...
Sheng Li +7 more
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Scanning curves and kinetics of the acetylcholine/acetylcholine receptor hysteresis [PDF]
, 1988 Neumann E, Boldt E, Rauer B, Wolf H, Chang HW. Scanning curves and kinetics of the acetylcholine/acetylcholine receptor hysteresis. Bioelectrochemistry and Bioenergetics.
Hendrik Wolf +9 more
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