Evaluating Commercially Available Antibodies for Rat α7 Nicotinic Acetylcholine Receptors. [PDF]
J Histochem Cytochem, 2017 Alpha7 nicotinic acetylcholine receptors (α7 nAChRs) are important drug targets in neurological disorders and inflammation, making their detection and localization by validated antibodies highly desirable.
Garg BK, Loring RH.
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Menthol binding and inhibition of α7-nicotinic acetylcholine receptors. [PDF]
PLoS ONE, 2013 Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes. The molecular targets of menthol remain poorly defined.
Abrar Ashoor +11 more
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Inhibition of Human α7 Nicotinic Acetylcholine Receptors by Cyclic Monoterpene Carveol [PDF]
European Journal of Pharmacology, 2016 Cyclic monoterpenes are a group of phytochemicals with antinociceptive, local anesthetic, and anti-inflammatory actions. Effects of cyclic monoterpenes including vanilin, pulegone, eugenole, carvone, carvacrol, carveol, thymol, thymoquinone, menthone ...
Yang, Keun-Hang Susan +8 more
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British Journal of Pharmacology, 2017 Background and purposeNeonicotinoid insecticides are described as poor agonists of mammalian nicotinic acetylcholine receptors. In this paper, we provide evidence that they diffenrently act on mammalian nicotinic receptors.Experimental approachTwo ...
Martin, Carine +5 more
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Neuroimmune nexus in the pathophysiology and therapy of inflammatory disorders: Role of α7 nicotinic acetylcholine receptors. [PDF]
Pharmacol Res, 2023 The α7-nicotinic acetylcholine receptor (α7nAChR) is a key protein in the cholinergic anti-inflammatory pathway (CAP) that links the nervous and immune systems.
Keever KR, Yakubenko VP, Hoover DB.
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Lovastatin Potentiates the Function of α7-Nicotinic Acetylcholine Receptors
PharmaceuticalsBackground/Objectives: Statins are currently one of the most commonly used cholesterol-lowering drugs. In recent years, in addition to their well-known effects on the cardiovascular system, statins have been shown to exert beneficial effects in the ...
Dmytro Isaev +2 more
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α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity. [PDF]
Trends Neurosci, 2022 Cholinergic innervation of the hippocampus uses the neurotransmitter acetylcholine (ACh) to coordinate neuronal circuit activity while simultaneously influencing the function of non-neuronal cell types.
Letsinger AC, Gu Z, Yakel JL.
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Homomeric and Heteromeric α7 Nicotinic Acetylcholine Receptors in Health and Some Central Nervous System Diseases. [PDF]
Membranes (Basel), 2021 Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in the modulation of essential brain functions such as memory, learning, and attention.
Borroni V, Barrantes FJ.
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Therapeutic Targeting of <i>α</i>7 Nicotinic Acetylcholine Receptors. [PDF]
Pharmacol Rev, 2021 The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all the members of the cys-loop superfamily of ligand-gated ion channels.
Papke RL, Horenstein NA.
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α7 nicotinic acetylcholine receptors as therapeutic targets in schizophrenia: Update on animal and clinical studies and strategies for the future. [PDF]
Neuropharmacology, 2020 Schizophrenia is a devastating mental illness and its effective treatment is among the most challenging issues in psychiatry. The symptoms of schizophrenia are heterogeneous ranging from positive symptoms (e.g., delusions, hallucinations) to negative ...
Terry AV, Callahan PM.
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