Synthesis and Antagonist Activity of Methyllycaconitine Analogues on Human α7 Nicotinic Acetylcholine Receptors. [PDF]
ACS Bio Med Chem Au, 2023 Methyllycaconitine (MLA), 1, is a naturally occurring norditerpenoid alkaloid that is a highly potent (IC50 = 2 nM) selective antagonist of α7 nicotinic acetylcholine receptors (nAChRs).
Qasem AMA +4 more
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A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE. [PDF]
Brain Behav Immun, 2020 Nicotinic acetylcholine receptors (nAChRs) are best known to function as ligand-gated ion channels in the nervous system. However, recent evidence suggests that nicotine modulates inflammation by desensitizing non-neuronal nAChRs, rather than by inducing
Godin JR +10 more
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Progress in neurobiology, 2021 The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to synaptic plasticity and memory acting through α7 subtype nicotinic ...
Maria Rosaria Tropea +7 more
semanticscholar +1 more source
α7 nicotinic acetylcholine receptors in lung cancer. [PDF]
Oncol Lett, 2018 Lung cancer has one of the highest mortality rates among malignancies globally, and smoking has been documented as the main cause of lung cancer. Nicotinic acetylcholine receptors (nAChRs) were initially identified as notable regulators of the nervous ...
Wang S, Hu Y.
europepmc +2 more sources
International Journal of Molecular Sciences, 2023 Nicotinic acetylcholine receptors (nAChRs) present as many different subtypes in the nervous and immune systems, muscles and on the cells of other organs.
I. Shelukhina +5 more
semanticscholar +1 more source
GTS-21 has cell-specific anti-inflammatory effects independent of α7 nicotinic acetylcholine receptors. [PDF]
PLoS One, 2019 α7 Nicotinic acetylcholine receptors (nAChRs) reportedly reduce inflammation by blocking effects of the important pro-inflammatory transcription factor, nuclear factor kappa-light chain-enhancer of B cells (NFκB).
Garg BK, Loring RH.
europepmc +2 more sources
Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility
Frontiers in Neurology, 2021 A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully ...
Peng Sun, Da-Gang Liu, Xiang-Ming Ye
doaj +1 more source
NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly
Cell Reports, 2020 Summary: The α7 nicotinic acetylcholine receptor participates in diverse aspects of brain physiology and disease. Neurons tightly control α7 assembly, which relies upon NACHO, an endoplasmic reticulum (ER)-localized integral membrane protein.
Hae-Jin Kweon +7 more
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Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor
Nature Communications, 2022 The intracellular domain (ICD) of Cys-loop receptors mediates many of their functions, but no complete structure of a Cys-loop receptor ICD is available to date.
Vasyl Bondarenko +12 more
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Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors. [PDF]
Br J Pharmacol, 2018 The alkaloid galantamine was originally isolated from the green snowdrop Galanthus woronowii and is currently marketed as a drug for treatment of mild to moderate dementia in patients with Alzheimer's disease. In addition to a well‐documented proficiency
Kowal NM +8 more
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