Results 21 to 30 of about 9,433 (135)

NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly

Cell Reports, 2020
Summary: The α7 nicotinic acetylcholine receptor participates in diverse aspects of brain physiology and disease. Neurons tightly control α7 assembly, which relies upon NACHO, an endoplasmic reticulum (ER)-localized integral membrane protein.
Hae-Jin Kweon, Shenyan Gu, Emily Witham, Madhurima Dhara, Hong Yu, Elodie Desuzinges Mandon, Anass Jawhari, David S. Bredt   +7 more
doaj   +1 more source

Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor

Nature Communications, 2022
The intracellular domain (ICD) of Cys-loop receptors mediates many of their functions, but no complete structure of a Cys-loop receptor ICD is available to date.
Vasyl Bondarenko, Marta M. Wells, Qiang Chen, Tommy S. Tillman, Kevin Singewald, Matthew J. Lawless, Joel Caporoso, Nicole Brandon, Jonathan A. Coleman, Sunil Saxena, Erik Lindahl, Yan Xu, Pei Tang   +12 more
doaj   +1 more source

Nicotinic potentiation of frog retinotectal transmission in tectum layer F by α3β2, α4β2, α2β4, α6β2, or α7 acetylcholine receptor subtypes

Medicina, 2015
Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas, Vilija Kuraitė, Antanas Kuras   +2 more
doaj   +1 more source

Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons

Stem Cell Research, 2019
The α7 nicotinic acetylcholine receptor has been extensively researched as a target for treatment of cognitive impairment in Alzheimer's disease and schizophrenia.
Hjalte M. Larsen, Susanne K. Hansen, Jens D. Mikkelsen, Poul Hyttel, Tina C. Stummann   +4 more
doaj   +1 more source

Effects mediated by the α7 nicotinic acetylcholine receptor on cell proliferation and migration in rat adipose-derived stem cells

European Journal of Histochemistry, 2020
Adipose-derived stem cells (ASCs) are an attractive source for regenerative medicine as they can be easily isolated, rapidly expandable in culture and show excellent in vitro differentiation potential.
Marta Pernarella, Roberta Piovesana, Carlo Matera, Alessandro Faroni, Mario Fiore, Luciana Dini, Adam J. Reid, Clelia Dallanoce, Ada Maria Tata   +8 more
doaj   +1 more source

Menthol binding and inhibition of α7-nicotinic acetylcholine receptors. [PDF]

PLoS ONE, 2013
Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes. The molecular targets of menthol remain poorly defined.
Abrar Ashoor, Jacob C Nordman, Daniel Veltri, Keun-Hang Susan Yang, Lina Al Kury, Yaroslav Shuba, Mohamed Mahgoub, Frank C Howarth, Bassem Sadek, Amarda Shehu, Nadine Kabbani, Murat Oz   +11 more
doaj   +1 more source

Small molecule ligands for α9 * and α7 nicotinic receptors: A survey and an update, respectively

Pharmacological Research, 2023
The α9- and α7-containing nicotinic acetylcholine receptors (nAChRs) mediate numerous physiological and pathological processes by complex mechanisms that are currently the subject of intensive study and debate.
Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi   +2 more
doaj   +1 more source

Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2.

PLoS ONE, 2014
Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder Bitis
Catherine A Vulfius, Igor E Kasheverov, Vladislav G Starkov, Alexey V Osipov, Tatyana V Andreeva, Sergey Yu Filkin, Elena V Gorbacheva, Maxim E Astashev, Victor I Tsetlin, Yuri N Utkin   +9 more
doaj   +1 more source

Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors.

PLoS ONE, 2021
Cholinergic modulation of hippocampal network function is implicated in multiple behavioral and cognitive states. Activation of nicotinic and muscarinic acetylcholine receptors affects neuronal excitability, synaptic transmission and rhythmic ...
Olha Zapukhliak, Olga Netsyk, Artur Romanov, Oleksandr Maximyuk, Murat Oz, Gregory L Holmes, Oleg Krishtal, Dmytro Isaev   +7 more
doaj   +1 more source

A G protein‐coupled α7 nicotinic receptor regulates signaling and TNF‐α release in microglia

FEBS Open Bio, 2017
Acetylcholine activation of α7 nicotinic acetylcholine receptors (α7 nAChRs) in microglia attenuates neuroinflammation and regulates TNF‐α release. We used lipopolysaccharide to model inflammation in the microglial cell line EOC20 and examined signaling ...
Justin R. King, Trudy C. Gillevet, Nadine Kabbani   +2 more
doaj   +1 more source