Results 41 to 50 of about 14,399 (162)

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10

Frontiers in Cellular Neuroscience, 2017
Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1β (IL-1β) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of α7, α9 and/or α10 subunits ...
Anna Zakrzewicz, Katrin Richter, Alisa Agné, Sigrid Wilker, Kathrin Siebers, Bijan Fink, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Mike Althaus, Mike Althaus, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh, Veronika Grau, Veronika Grau   +17 more
doaj   +1 more source

Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse. [PDF]

, 2019
Homomeric α7 nicotinic acetylcholine receptors (nAChRs) are abundantly expressed in the central and peripheral nervous system (CNS and PNS, respectively), and spinal cord.
Broide, Ron S, Chen, Yling, Leslie, Frances M, Winzer-Serhan, Ursula H   +3 more
core   +1 more source

Expression of the α7 nicotinic acetylcholine receptor in human lung cells [PDF]

, 2005
Background We and others have shown that one of the mechanisms of growth regulation of small cell lung cancer cell lines and cultured pulmonary neuroendocrine cells is by the binding of agonists to the α7 neuronal nicotinic acetylcholine receptor.
O Delbono, MG Cattaneo, A Codignola, HM Schuller, HM Schuller, HK Plummer III, BJ Sheppard, P Tarroni, HM Schuller, BA Jull, DE Johnson, HM Schuller, HK Plummer III, X Peng, DL Carlisle, S Couturier, J Lindstrom, P Song, P Song, HM Schuller, L Ke, M Bencherif, S Wonnacott, HS Sekhorn   +23 more
core   +2 more sources

Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons. [PDF]

PLoS ONE, 2015
Neurons derived from human induced pluripotent stem cells (iPSCs) represent a potentially valuable tool for the characterisation of neuronal receptors and ion channels.
Anna Chatzidaki, Antoine Fouillet, Jingling Li, Jeffrey Dage, Neil S Millar, Emanuele Sher, Daniel Ursu   +6 more
doaj   +1 more source

Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]

, 1995
Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K., Blumenthal, Edward M, Huang, Bo, Vijayaraghavan, Sukumar   +3 more
core   +2 more sources

An experimental study on (131)I-CHIBA-1001: a radioligand for α7 nicotinic acetylcholine receptors. [PDF]

PLoS ONE, 2013
OBJECTIVE: The α7 nicotinic acetylcholine receptors (nAChRs) play a vital role in the pathophysiology of neuropsychiatric diseases such as Alzheimer's disease and depression.
Lei Yin, Qian Zhao, Ling Li, Su Lei Zhang, Xue Qi Chen, Chao Ma, Lei Kang, Meng Liu, Chun Li Zhang, Ping Yan, Rong Fu Wang   +10 more
doaj   +1 more source

Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation

Pharmacological Research, 2023
Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstrated
Arik J. Hone, J. Michael McIntosh
doaj   +1 more source

Inside-out neuropharmacology of nicotinic drugs [PDF]

, 2015
Upregulation of neuronal nicotinic acetylcholine receptors (AChRs) is a venerable result of chronic exposure to nicotine; but it is one of several consequences of pharmacological chaperoning by nicotine and by some other nicotinic ligands, especially ...
Henderson, Brandon J., Lester, Henry A.
core   +1 more source

Unique nicotinic responses are present in distinct subtypes of mouse medial prefrontal layer V pyramidal neurons

Scientific Reports
The neurotransmitter acetylcholine supports goal-directed cognitive functions via activation of its nicotinic and muscarinic classes of receptors within the prefrontal cortex.
Ashutosh V. Patel, Anthony Nguyen, Ashley A. Geremia, Donia Zeng, Pietro Paletta, Elena Choleris, Craig D. C. Bailey   +6 more
doaj   +1 more source

Presynaptic Terminal Proteins and Nicotinic Receptors Are Depleted from Mouse Parasympathetic Ganglionic Junctions Paralysed with Botulinum Neurotoxin Type A

Toxins
Plasticity is fundamental to the development, strengthening, and maintenance of healthy synaptic connections and recovery from injury in both the central and peripheral nervous systems. Yet, the processes involved are poorly understood.
Ahmed Al-Sabi, Gary W. Lawrence
doaj   +1 more source