Results 61 to 70 of about 9,433 (135)

Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation

Frontiers in Neuroscience
Nicotinic receptor signaling is influential in modulating appropriate responses to salient stimuli within a complex environment. The cholinergic neurotransmitter system drives attention to salient stimuli such as stressors, and aids in orchestrating the ...
Kristin R. Anderson, Peter J. Rogu, Talulla B. Palumbo, Julie M. Miwa   +3 more
doaj   +1 more source

tVNS Mitigates Neuroinflammation and Nociception in a Rodent LPS Endotoxemia Model

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
Experimental design and key findings. Four groups (Control+Sham, Control+tVNS, LPS+Sham, LPS+tVNS; n = 7 each) underwent serum ELISA, brain Western blot, and behavioral testing. tVNS altered serum Haptoglobin, IL‐6, CGRP1, and VE‐Cadherin levels, reversed LPS‐induced increases in brain IL‐1β, HMGB1, Haptoglobin, PAR‐2, and CGRP, and alleviated LPS ...
Kerem Atalar, Ece Alim, Aysen Calikusu, Elif Gulcicek Abbasoglu Topa, Hale Gok Dagidir, Meltem Bahcelioglu, Neslihan Bukan, Fusun Erten, Kazım Sahin, Saadet Özen Akarca Dizakar, Hayrunnisa Bolay   +10 more
wiley   +1 more source

Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E₂ in rat microglial cultures

Journal of Neuroinflammation, 2005
Background Nicotinic acetylcholine (Ach) receptors are ligand-gated pentameric ion channels whose main function is to transmit signals for the neurotransmitter Ach in peripheral and central nervous system.
Minghetti Luisa, Carnevale Daniela, Ajmone-Cat Maria, De Simone Roberta   +3 more
doaj   +1 more source

Skin Boosters: 2026 Updated

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Skin boosters are increasingly used to improve dermal quality through injectable and device‐assisted approaches; however, definitions and clinical evidence remain heterogeneous. Aims To provide an updated overview and propose a practical classification of skin boosters, including mechanisms, delivery methods, clinical outcomes, and limitations.
Kyu‐ho Yi, Hyunggyu Kang, Jong Keun Song, Olena Sydorchuk, Jeremy B. Green, Hugues Cartier, Roya Zarmehr Zamin, Benjamin Ascher   +7 more
wiley   +1 more source

Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors

Beilstein Journal of Organic Chemistry, 2007
BackgroundThe 5,8-disubstituted indolizidines constitute the largest class of poison-frog alkaloids. Some alkaloids have been shown to act as noncompetitive blockers at nicotinic acetylcholine receptors but the proposed structures and the biological ...
Soushi Kobayashi, Naoki Toyooka, Dejun Zhou, Hiroshi Tsuneki, Tsutomu Wada, Toshiyasu Sasaoka, Hideki Sakai, Hideo Nemoto, H. Martin Garraffo, Thomas F. Spande, John W. Daly   +10 more
doaj   +1 more source

Note for Male Smokers: The Healthy Eating Index Associated With the Risk of Subclinical Myocardial Injury

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Flow chart of the study population. ABSTRACT Objectives To investigate the associations of the healthy eating index (HEI) and subclinical myocardial injury (SCMI) in different smoking statuses (current smokers, former smokers, and never smokers) based on the National Health and Nutrition Examination Survey (NHANES) III.
Zhi‐jin Li, Bin‐gui Li
wiley   +1 more source

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source

Lovastatin Potentiates the Function of α7-Nicotinic Acetylcholine Receptors

Pharmaceuticals
Background/Objectives: Statins are currently one of the most commonly used cholesterol-lowering drugs. In recent years, in addition to their well-known effects on the cardiovascular system, statins have been shown to exert beneficial effects in the ...
Dmytro Isaev, Keun-Hang Susan Yang, Murat Oz   +2 more
doaj   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 402-431, May 2026.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source