Results 81 to 90 of about 624,184 (210)

Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse

Scientific Reports, 2017
In neonatal mice motoneurons excite Renshaw cells by releasing both acetylcholine (ACh) and glutamate. These two neurotransmitters activate two types of nicotinic receptors (nAChRs) (the homomeric α7 receptors and the heteromeric α*ß* receptors) as well
Boris Lamotte d’Incamps, Gardave S. Bhumbra, Joshua D. Foster, Marco Beato, Philippe Ascher   +4 more
doaj   +1 more source

Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs. [PDF]

PLoS ONE, 2013
Functional α7 nicotinic acetylcholine receptors (AChRs) do not assemble efficiently in cells transfected with α7 subunits unless the cells are also transfected with the chaperone protein RIC-3.
Alexander Kuryatov, Jayanta Mukherjee, Jon Lindstrom   +2 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Heterogenous Cholinergic Nicotinic Receptors in the CNS

, 1988
Multiple nicotinic binding sites are found in mammalian brain. Several nicotinic agonists and antagonists have been used to characterize the nicotinic binding sites.
Nilsson, L, Abdu Adem, Luciana Romanelli, Nordberg, A, Lena Nilsson, Adem, A, Xiao Zhang, Zhang, X, Agneta Nordberg, Romanelli, L   +9 more
core   +1 more source

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity [PDF]

, 2007
Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack ...
Sixma, Titia K., Alewood, Paul F., Buettner, Regina, van Elk, R, Smit, A.B., Sixma, T., Dutertre, S., Nicke, A, van Elk, R., Smit, A., Nicke, Annette, Alewood, P. F., Sixma, T.K., Kendel, Y., Smit, AB, Lewis, R. J., Hopping, G., Kendel, Y, van Elk, René, Büttner, Regina, Elk, René van, Ulens, C, Ulens, Chris, Buttner, R, Kendel, Yvonne, Sixma, TK, Fish, Alexander, Lewis, R.J., Schroeder, Christina, Lewis, Richard,, Smit, August,, Buttner, R., Elk, R. van, Alewood, P.F., Lewis, Richard J., Fish, A, Sixma, Titia,, Schroeder, C., Alewood, Paul,, Fish, A., Alewood, P., Dutertre, Sébastien, Smit, August B., Ulens, C., Hopping, Gene, Nicke, A., Lewis, R.   +46 more
core   +1 more source

Diabetic Autonomic Neuropathy and Impaired Inflammatory Reflex

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
The cholinergic anti‐inflammatory pathway under normal and diabetic conditions. In the normal state, vagal activation through nicotinic acetylcholine receptors helps regulate immune responses and suppress excessive inflammation. In diabetes, impaired autonomic function and dysregulated cholinergic signalling weaken this anti‐inflammatory pathway ...
Narges Dastmalchi, Mohammad Amin Doustvandi, Reza Rahbarghazi, Khalil Hajiasgharzadeh   +3 more
wiley   +1 more source

Stimulating Neuroprotective and Regenerative Mechanisms in Alzheimer Disease [PDF]

, 2013
The processes involved in neuroprotection and brain repair are an important aspect of the preservation and restoration of neuronal functions affected by pathological lesions.
Lilja, Anna M
core   +1 more source

Regarding: Nicotinic acetylcholine receptors α7 and α9 modify tobacco smoke risk for multiple sclerosis. [PDF]

, 2020
This is a author manuscript of an article accepted for publication in Multiple Sclerosis Journal. Version of record is available online at Jacobs BM, Smets I, Giovannoni G, Noyce A, Jokubaitis V, Dobson R. Regarding: Nicotinic acetylcholine receptors α7
Jokubaitis, V, Smets, I, Jacobs, BM, Noyce, A, Giovannoni, G, Dobson, R   +5 more
core   +1 more source

Calcium imaging with genetically encoded sensor Case12: Facile analysis of α7/α9 nAChR mutants.

PLoS ONE, 2017
Elucidation of the structural basis of pharmacological differences for highly homologous α7 and α9 nicotinic acetylcholine receptors (nAChRs) may shed light on their involvement in different physiological functions and diseases.
Irina Shelukhina, Ekaterina Spirova, Denis Kudryavtsev, Lucy Ojomoko, Markus Werner, Christoph Methfessel, Michael Hollmann, Victor Tsetlin   +7 more
doaj   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, Volume 13, Issue 55, 5 October 2026.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source