Results 91 to 100 of about 624,184 (210)

The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Jie Liu, Kui Sun, Hongmei Liu, Meiyang Zhu, Chunmeng Li, Yuqi He, Lin Qin   +6 more
wiley   +1 more source

Involvement of stimulation of α7 nicotinic acetylcholine receptors in the suppressive effect of tropisetron on dextran sulfate sodium-induced colitis in mice.

Journal of Pharmacological Sciences, 2015
Ulcerative colitis (UC) involves chronic inflammation of the large intestine. Several agents are used to treat UC, but adverse side effects are remaining problems. We examined the effect of tropisetron as a new type of drug for UC using a dextran sulfate
Yuichi Tasaka, Daiki Yasunaga, T. Kiyoi, Mamoru Tanaka, Akihiro Tanaka, K. Suemaru, Hiroaki Araki   +6 more
semanticscholar   +1 more source

Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation

Frontiers in Neuroscience
Nicotinic receptor signaling is influential in modulating appropriate responses to salient stimuli within a complex environment. The cholinergic neurotransmitter system drives attention to salient stimuli such as stressors, and aids in orchestrating the ...
Kristin R. Anderson, Peter J. Rogu, Talulla B. Palumbo, Julie M. Miwa   +3 more
doaj   +1 more source

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, Volume 9, Issue 9, Page 1828-1848, September 2026.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source

Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker

Current pharmaceutical design, 2015
Accumulating evidence suggests that the α7 subtype of nicotinic acetylcholine receptors (nAChRs) plays a key role in inflammatory processes, thought to be involved in the pathophysiology of neuropsychiatric diseases, such as schizophrenia and Alzheimer’s
K. Hashimoto
semanticscholar   +1 more source

Therapeutic Potential of Oxiracetam in Neurocognitive Disorders: A Narrative Review

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Purpose: Cognitive impairment is a growing global health concern associated with aging, neurodegenerative diseases, stroke, and traumatic brain injury. Existing pharmacological treatments, including cholinesterase inhibitors and memantine, provide limited and variable benefits.
Hafsa Ali, Syeda Maliha, Sundas Ishtiaq, Omer Al‐Karawi, Mohammed Hammad Jaber Amin   +4 more
wiley   +1 more source

Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E₂ in rat microglial cultures

Journal of Neuroinflammation, 2005
Background Nicotinic acetylcholine (Ach) receptors are ligand-gated pentameric ion channels whose main function is to transmit signals for the neurotransmitter Ach in peripheral and central nervous system.
Minghetti Luisa, Carnevale Daniela, Ajmone-Cat Maria, De Simone Roberta   +3 more
doaj   +1 more source

Calvarial Bone Channels and a Putative Craniomaxillary–Brain Interface in Central Nervous System Immunity

Med Research, EarlyView.
Ziwen Sheng, Yulong Zhang, Hao Wang, Wenyu Zhen, Youming Zhu, Haitao Wang, Hengguo Zhang   +6 more
wiley   +1 more source

Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
The cycle between nicotine use and pain modulation. Cigarette smoking leads to nicotine entering the body, which binds to nicotinic acetylcholine receptors (nAChRs) in the brain, triggering the release of different neurotransmitters, including dopamine (DA), norepinephrine (NE), serotonin (5‐HT), and GABA.
Shan‐shan Hu, Chao‐feng Zhang, Battuvshin Lkhagvasuren, Di Wang   +3 more
wiley   +1 more source

Nicotinic Acetylcholine Receptors are Possible Therapeutic Targets for Schizophrenia [PDF]

, 2010
The rate of smoking in patients with schizophrenia is higher than that in the general population. Nicotinic acetylcholine receptors (nAChR) are involved in the sensorimotor gating deficits in schizophrenia.
川崎, 博己, 荒木, 博陽, 45288, 45289, 鴻海, 俊太郎, 町支, 臣成, 45291, 末丸, 克矢, 45290, 日比野, 俐, 45293, 45292   +11 more
core