Results 71 to 80 of about 624,184 (210)
The role of neuronal nicotinic acetylcholine receptors in central cardiovascular regulation. [PDF]
, 2007 The central effect of nicotine on cardiovascular regulation has been extensively studied. However, due to its unselective nature for nicotinic acetylcholine receptors (nAChR) the involvement of specific nAChRs at sites in the brain, in central nervous ...
Moore, C.
core
, 1988 Several studies showed clearly that the mammalian central nervous system possess nicotinic receptors. Recently, using membrane receptor binding studies the regional distribution of 3H-nicotine and/or H-acetylcholine binding sites in the human brain has ...
Abdu Adem +9 more
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Nature CommunicationsEpilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and
Quynh-Anh Nguyen +13 more
doaj +1 more source
BMC Neuroscience, 2005 Background Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most intensively studied nAChR subunits
Sansom Mark SP +6 more
doaj +1 more source
Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596. [PDF]
PLoS ONE, 2012 Positive allosteric modulators of highly Ca(2+)-permeable α7 nicotinic acetylcholine receptors, such as PNU-120596, may become useful therapeutic tools supporting neuronal survival and function.
Victor V Uteshev
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Cells, 2022 Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by intestinal dysmotility. Changes in intestinal microbiota (dysbiosis) can lead to alterations in neuro-muscular functions in the gut. Toll-like receptors (TLRs) 2 and 4
Elena Layunta +2 more
doaj +1 more source
Immunology, EarlyView.Activated T‐cells instigate signalling events leading to the activation of transcription factors, which in turn, act on the nucleus to produce cytokines. We postulate that c‐fos is one of these transcription factors which upregulates the choline acetyltransferase gene responsible for synthesising acetylcholine (ACh).
Jarita Lay, Nicholas Manolios
wiley +1 more source
Studying the function of α7 nicotinic acetylcholine receptor in Drosophila humoral immunity
, 2023 Acetylcholine (ACh) is one the major neurotransmitters, whose role in mediating synaptic interactions between neurons in the central nervous system in vertebrates and invertebrates is well characterized.
Giulia Cattabriga +7 more
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Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. [PDF]
PLoS ONE, 2014 Three recently discovered tentacle muscles are crucial to perform patterned movements of upper tentacles of the terrestrial snail, Helix pomatia. The muscles receive central and peripheral excitatory cholinergic innervation lacking inhibitory innervation.
Tibor Kiss +3 more
doaj +1 more source
Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases
Journal of Periodontal Research, EarlyView.This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini +3 more
wiley +1 more source