Results 71 to 80 of about 9,433 (135)

The Effect of the Anticonvulsant Topiramate on Acetylcholine‐Induced Calcium Signals is Linked to Sirt‐1 Activity

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
This work provides a potential new link between the anticonvulsive Topiramate, the deacetylase Sirt‐1 and the cholinergic signalling, suggesting that Topiramate may modulate cholinergic pathways in a Sirt‐1 depended manner. ABSTRACT Although some forms of epilepsy directly result from mutations in nicotinic acetylcholine receptors, none of the ...
Marie‐Luise Kümmel
wiley   +1 more source

Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor

Cell Reports, 2016
Central insulin action activates hepatic IL-6/STAT3 signaling, which suppresses the gene expression of hepatic gluconeogenic enzymes. The vagus nerve plays an important role in this centrally mediated hepatic response; however, the precise mechanism ...
Kumi Kimura, Mamoru Tanida, Naoto Nagata, Yuka Inaba, Hitoshi Watanabe, Mayumi Nagashimada, Tsuguhito Ota, Shun-ichiro Asahara, Yoshiaki Kido, Michihiro Matsumoto, Koji Toshinai, Masamitsu Nakazato, Toshishige Shibamoto, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue   +15 more
doaj   +1 more source

Symmetry-adapted Markov state models of closing, opening, and desensitizing in α 7 nicotinic acetylcholine receptors

Nature Communications
α7 nicotinic acetylcholine receptors (nAChRs) are homopentameric ligand-gated ion channels with critical roles in the nervous system. Recent studies have resolved and functionally annotated closed, open, and desensitized states of these receptors ...
Yuxuan Zhuang, Rebecca J. Howard, Erik Lindahl   +2 more
doaj   +1 more source

Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria.

PLoS ONE, 2012
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate synaptic transmission in the muscle and autonomic ganglia and regulate transmitter release in the brain.
Galyna Gergalova, Olena Lykhmus, Olena Kalashnyk, Lyudmyla Koval, Volodymyr Chernyshov, Elena Kryukova, Victor Tsetlin, Sergiy Komisarenko, Maryna Skok   +8 more
doaj   +1 more source

SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors. [PDF]

J Biol Chem, 2023
O'Brien BCV, Weber L, Hueffer K, Weltzin MM.   +3 more
europepmc   +1 more source

Neuroimmune nexus in the pathophysiology and therapy of inflammatory disorders: Role of α7 nicotinic acetylcholine receptors. [PDF]

Pharmacol Res, 2023
Keever KR, Yakubenko VP, Hoover DB.
europepmc   +1 more source

Subtype-Selective Peptide and Protein Neurotoxic Inhibitors of Nicotinic Acetylcholine Receptors Enhance Proliferation of Patient-Derived Glioblastoma Cell Lines

Toxins
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, with a poor prognosis. GBM cells, which develop in the environment of neural tissue, often exploit neurotransmitters and their receptors to promote their own growth and invasion ...
Elena Gondarenko, Diana Mazur, Marina Masliakova, Yana Ryabukha, Igor Kasheverov, Yuri Utkin, Victor Tsetlin, Mikhail Shahparonov, Denis Kudryavtsev, Nadine Antipova   +9 more
doaj   +1 more source

Editorial Note: HIV gp120 Induces Mucus Formation in Human Bronchial Epithelial Cells through CXCR4/α7-Nicotinic Acetylcholine Receptors. [PDF]

PLoS One, 2023
PLOS ONE Editors.
europepmc   +1 more source

Synthesis and Antagonist Activity of Methyllycaconitine Analogues on Human α7 Nicotinic Acetylcholine Receptors. [PDF]

ACS Bio Med Chem Au, 2023
Qasem AMA, Rowan MG, Sanders VR, Millar NS, Blagbrough IS.   +4 more
europepmc   +1 more source

α7 Nicotinic Acetylcholine Receptors May Improve Schwann Cell Regenerating Potential via Metabotropic Signaling Pathways. [PDF]

Cells, 2023
Botticelli E, Guerriero C, Fucile S, De Stefano ME, Matera C, Dallanoce C, De Amici M, Tata AM.   +7 more
europepmc   +1 more source