Results 111 to 120 of about 624,184 (210)

β-Amyloid Peptide Activates α7 Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes*

Journal of Biological Chemistry, 2002
The α7 nicotinic acetylcholine receptor is highly expressed in hippocampus and in cholinergic projection neurons from the basal forebrain, structures that are particularly vulnerable to the ravages of Alzheimer's disease.
K. Dineley, K. Bell, D. Bui, J. Sweatt
semanticscholar   +1 more source

Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors

European Journal of Pharmacology, 2012
The effect of the (R,S)-ketamine metabolites (R,S)-norketamine, (R,S)-dehydronorketamine, (2S,6S)-hydroxynorketamine and (2R,6R)- hydroxynorketamine on the activity of α7 and α3β4 neuronal nicotinic acetylcholine receptors was investigated using patch ...
R. Moaddel, G. Abdrakhmanova, Joanna Kozak, K. Jóźwiak, L. Toll, L. Jimenez, A. Rosenberg, Thao Tran, Yingxian Xiao, C. Zarate, I. Wainer   +10 more
semanticscholar   +1 more source

Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens [PDF]

, 2004
The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine ...
Burzomato, V., Beato, M., Colquhoun, D., Groot-Kormelink, P.J., Sivilotti, L.G.   +4 more
core  

Activation of α7 nicotinic acetylcholine receptors prevents monosodium iodoacetate-induced osteoarthritis in rats.

Cellular Physiology and Biochemistry, 2015
BACKGROUND/AIMS Although some evidence suggests that the prevalence of osteoarthritis (OA) is lower in smokers compared to nonsmokers, the mechanisms of nicotine-induced protection remain unclear.
Yuan Liu, Dong-Ying Wu, Fang-Long Song, Chenlei Zhu, Yu-jian Hui, Qingcheng Zhu, Jie Wu, Wei-Min Fan, Jun Hu   +8 more
semanticscholar   +1 more source

Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects

Journal of Biological Chemistry, 2014
Background: Nicotinic receptors are activated by acetylcholine and have been implicated in several neurological disorders. Results: Allosteric modulators, sharing close chemical similarity, exhibit five distinct pharmacological effects on α7 nicotinic ...
JasKiran K. Gill-Thind, P. Dhankher, J. D'oyley, Tom D. Sheppard, N. Millar   +4 more
semanticscholar   +1 more source

Molecular characterisation of insect nicotinic acetylcholine receptors [PDF]

, 2003
Nicotinic acetylcholine receptors (nAChRs) are pentameric multi-subunit proteins that form ligand-gated ion channels in the central nervous systems of vertebrates and invertebrates and at the neuromuscular junction of vertebrate species. In insects, they
Kirwan, M. J., Kirwan, Michael Joseph
core  

Presynaptic α7 Nicotinic Acetylcholine Receptors Enhance Hippocampal Mossy Fiber Glutamatergic Transmission via PKA Activation

Journal of Neuroscience, 2014
Nicotinic acetylcholine receptors (nAChRs) are expressed widely in the CNS, and mediate both synaptic and perisynaptic activities of endogenous cholinergic inputs and pharmacological actions of exogenous compounds (e.g., nicotine and choline). Behavioral
Qing Cheng, J. Yakel
semanticscholar   +1 more source

Symmetry-adapted Markov state models of closing, opening, and desensitizing in α 7 nicotinic acetylcholine receptors

Nature Communications
α7 nicotinic acetylcholine receptors (nAChRs) are homopentameric ligand-gated ion channels with critical roles in the nervous system. Recent studies have resolved and functionally annotated closed, open, and desensitized states of these receptors ...
Yuxuan Zhuang, Rebecca J. Howard, Erik Lindahl   +2 more
doaj   +1 more source

Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor

Cell Reports, 2016
Central insulin action activates hepatic IL-6/STAT3 signaling, which suppresses the gene expression of hepatic gluconeogenic enzymes. The vagus nerve plays an important role in this centrally mediated hepatic response; however, the precise mechanism ...
Kumi Kimura, Mamoru Tanida, Naoto Nagata, Yuka Inaba, Hitoshi Watanabe, Mayumi Nagashimada, Tsuguhito Ota, Shun-ichiro Asahara, Yoshiaki Kido, Michihiro Matsumoto, Koji Toshinai, Masamitsu Nakazato, Toshishige Shibamoto, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue   +15 more
doaj   +1 more source

α7-Containing and Non-α7-Containing Nicotinic Receptors Respond Differently to Spillover of Acetylcholine

, 2011
We explored whether nicotinic acetylcholine receptors (nAChRs) might participate in paracrine transmission by asking if they respond to spillover of ACh at a model synapse in the chick ciliary ganglion, where ACh activates diffusely distributed α7- and ...
Doychin Stanchev, Peter B. Sargent
core   +1 more source