Results 121 to 130 of about 624,184 (210)

Rabies virus glycoprotein variants modulate neuronal nicotinic receptors in a conformation-dependent manner

Scientific Reports
Rabies encephalitis remains nearly 100% fatal once symptoms appear, and no effective treatments exist because the molecular mechanisms underlying neuronal disruption remain poorly understood.
Seyedeh Melika Akaberi,  Sabina Yeasmin, Pooja Sapkota, Kavita Sharma, Marvin Schulte   +4 more
doaj   +1 more source

Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria.

PLoS ONE, 2012
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate synaptic transmission in the muscle and autonomic ganglia and regulate transmitter release in the brain.
Galyna Gergalova, Olena Lykhmus, Olena Kalashnyk, Lyudmyla Koval, Volodymyr Chernyshov, Elena Kryukova, Victor Tsetlin, Sergiy Komisarenko, Maryna Skok   +8 more
doaj   +1 more source

Precise Localization of α7 Nicotinic Acetylcholine Receptors on Glutamatergic Axon Terminals in the Rat Ventral Tegmental Area

Journal of Neuroscience, 2004
α7 neuronal nicotinic acetylcholine receptors (nAChRs) constitute one of the predominant nAChR subtypes in the mammalian brain. Within the ventral tegmental area (VTA), nicotine application, paired with postsynaptic stimulation, contributes to a form of ...
I. Jones, S. Wonnacott
semanticscholar   +1 more source

Loop B is a major structural component of the 5-HT3 receptor [PDF]

, 2008
The 5-HT3 receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence of six peptide loops (A-F).
Thompson, Andrew J., Thompson, A.J., M. Lochner, Lummis, S. C. R., Lummis, S.C.R., S. C. R. Lummis, Lochner, M., A. J. Thompson, Lochner, Martin, Thompson, Andrew James   +9 more
core   +2 more sources

Kynurenic acid as an Antagonist of α7 Nicotinic Acetylcholine Receptors in the Brain: Facts and Challenges

Biochemical Pharmacology, 2012
Kynurenic acid (KYNA), a major tryptophan metabolite, is a glutamate receptor antagonist, which is also reported to inhibit α7 nicotinic acetylcholine receptors (α7nAChRs).
E. X. Albuquerque, R. Schwarcz
semanticscholar   +1 more source

SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors. [PDF]

J Biol Chem, 2023
O'Brien BCV, Weber L, Hueffer K, Weltzin MM.   +3 more
europepmc   +1 more source

Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]

, 2007
Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D., Groot-Kormelink, P., Plested, A.J.R., Sivilotti, L.G.   +3 more
core  

New spirocyclic Δ2-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors

, 2011
A set of structural analogues of spirocyclic quinuclidinyl- Δ2-isoxazolines, characterized as potent and selective α7 nicotinic agonists, was prepared and assayed for binding affinity at α7 and α4β2 neuronal nicotinic acetylcholine receptors (nAChRs ...
Clelia Dallanoce, C.M.L. Dallanoce, Cecilia Gotti, Sergio Fucile, Carlo De Micheli, Carlo Matera, C. Gotti, Fabio Frigerio, C. Matera, G.L. Visconti, FUCILE, Sergio, S. Fucile, Giovanni Grazioso, M. DE AMICI, Francesco Clementi, F. Clementi, G. Grazioso, Marco De Amici, Francesco Pistillo, Luca Pucci, L. Pucci, Giacomo Luca Visconti, F. Frigerio, F. Pistillo, C. DE MICHELI   +24 more
core   +1 more source

Acute lung injury in cholinergic-deficient mice supports anti-inflammatory role of α7 nicotinic acetylcholine receptor [PDF]

, 2021
(1) Background: The lung cholinergic pathway is important for controlling pulmonary inflammation in acute lung injury, a condition that is characterized by a sudden onset and intense inflammation.
Prado, Vivian F., Banzato, Rosana, Hamouda, Ayman K., Pinheiro, Nathalia M., Prado, Marco A. M., Tiberio, Lolanda, Prado, Carla M.   +6 more
core  

Pharmacological studies on acetylcholine and other transmitter receptors from invertebrate muscle and central neurones

, 1988
Muscle tension recordings were made from earthworm body wall muscle and the action of acetylcholine, cholinomimtics and cholinolytics examined. The effect of cholinergic agents on muscle twitches induced following field stimulation was also investigated.
Hassoni, Abdul-Nabi Atya, Hassoni, A.A
core   +1 more source