Results 171 to 180 of about 2,121,152 (251)

Exercise Training Attenuates Acute β-Adrenergic Receptor Activation-Induced Cardiac Inflammation via the Activation of AMP-Activated Protein Kinase. [PDF]

Int J Mol Sci, 2023
Zhang M, Alemasi A, Zhao M, Xu W, Zhang Y, Gao W, Yu H, Xiao H.   +7 more
europepmc   +1 more source

Change in β 1 -adrenergic receptor protein concentration in adipose tissue correlates with diet-induced weight loss

, 2005
A B S T R A C T The aim of the present study was to examine gene expression and protein concentrations of β 1 -and β 2 -adrenergic receptors in subcutaneous adipose tissue in obese subjects in response to weight loss. Eighteen obese subjects were studied
Palle Bratholm, Arne Astrup, Niels J Christensen, Mads Rasmussen, Søren Toubro, Anita Belza, Thomas Almdal   +6 more
core  

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Repurposing Drug Metabolites into Dual β-Adrenergic Receptor-Carbonic Anhydrase Modulators as Potential Tools for Ocular Disorders. [PDF]

J Med Chem
Ammara A, Carone A, Lucarini L, Sgambellone S, Marri S, Villano S, Matucci R, Luga G, Fittipaldi C, Pecori R, Pieraccini G, Di Serio C, García-Llorca A, Eysteinsson T, Kalinin S, Viita JAO, Urtti A, Carta F, Selleri S, Supuran CT.   +19 more
europepmc   +1 more source

Lubabegron fumarate acts as a β-adrenergic receptor antagonist in cultured bovine intramuscular and subcutaneous adipocytes. [PDF]

J Anim Sci, 2022
Hwang JH, Kube JC, Smith SB.
europepmc   +1 more source

Beta-adrenergic receptor regulation and airway inflammation

, 2005
There is ongoing concern that regular use of β2-agonists without additional use of inhaled steroids may contribute to an adverse outcome of asthma, which may in part be due to desensitization of the β2-adrenergic receptor (Chapter7 ). Therefore, there is
Oostendorp, Jaap
core  

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

β-adrenergic receptor inhibits heart regeneration by downregulating Yap m6A modification. [PDF]

Cell Death Dis
Guan K, Li Z, Li Z.
europepmc   +1 more source

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes. [PDF]

Proc Natl Acad Sci U S A, 2021
Bathe-Peters M, Gmach P, Boltz HH, Einsiedel J, Gotthardt M, Hübner H, Gmeiner P, Lohse MJ, Annibale P.   +8 more
europepmc   +1 more source

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source