Results 101 to 110 of about 1,157,409 (244)

Prevalence, knowledge and attitudes relating to β-alanine use among professional footballers

, 2017
Objectives To investigate β-alanine supplementation use and level of knowledge amongst professional footballers. Design Cross-sectional survey of Australian professional football players.
CT Brennan (14452272), DG Jenkins (9850859), VG Kelly (9867023), GJ Slater (14452275), MD Leveritt (9247337)   +4 more
core   +2 more sources

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Gene transfer efficacies of novel cationic amphiphiles with alanine, β-alanine, and serine headgroups: a structure-activity investigation

, 2005
Herein, we report on the relative in vitro efficacies of nine novel nonglycerol based cationic amphiphiles with increasing hydrophobic tails and the amino acids serine, alanine and β-alanine as the headgroup functionalities (lipids 1-9, Scheme 1) in ...
Sen, Joyeeta, Chaudhuri, Arabinda
core   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Synergistic antibacterial effects of β-Chloro-L-alanine and phosphomycin on urinary tract isolates of E. coli

Biological Journal of Microorganism, 2013
Introduction: The aim of this study was the evaluation of the synergistic effect of sub-MIC doses of Phosphomycin with β-Chloro-L-alanine against urinary tract isolates of E. coli.
Nima Hosseini Jazani, Omid Hadizadeh, Hamed Farzaneh, Milad Moloudizargari   +3 more
doaj  

NEUROTOXIC EFFECTS OF α-FLUORO-β-ALANINE (FBAL) AND FLUOROACETIC ACID (FA) ON DOGS

, 2004
In order to clarify the mechanism of the neurotoxicity of 5-FU and/or its masked compounds, we studied the effects of α-fluoro-β-alanine (FBAL) and fluoroacetic acid (FA) on the formation of vacuolar changes in the dog cerebrum, using the dosage of 3.0 ...
Ariyoshi, Toshihiko, Yamashita, Kazumasa, Yada, Hideaki   +2 more
core  

Performance effects of acute β-alanine induced paresthesia in competitive cyclists

, 2016
β-alanine is a common ingredient in supplements consumed by athletes. Indeed, athletes may believe that the β-alanine induced paresthesia, experienced shortly after ingestion, is associated with its ergogenic effect despite no scientific mechanism ...
Bellinger, Phil, Minahan, Clare, Bellinger, Phillip M, Minahan, Clare L   +3 more
core   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source