Results 1 to 10 of about 6,822 (183)

Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation

Antioxidants, 2021
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It is found in high concentrations in the brain, muscle, and gastrointestinal tissues of humans and is present in all vertebrates.
Marko Stupin, Aleksandar Kibel, Olivera Galovic   +2 more
exaly   +3 more sources

Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial [PDF]

Journal of the International Society of Sports Nutrition
Background Carnosine (β-alanine-L-histidine) is an endogenous dipeptide found in abundance in highly metabolic tissues such as skeletal muscle and the brain, where it is thought to play a role in intracellular buffering, and thereby, promote anaerobic ...
Timothy E. O'Toole, Christopher J. Wingard, Sonja K. Bariess, Catherine E. Crandell, Alok R. Amraotkar, Hong Gao, Aruni Bhatnagar   +6 more
doaj   +2 more sources

Exercise and β-alanine supplementation on carnosine-acrolein adduct in skeletal muscle

Redox Biology, 2018
Previous studies have demonstrated that exercise results in reactive aldehyde production and that β-alanine supplementation increases carnosine content in skeletal muscle.
Bruno Gualano, Luana Farias De Oliveira, Guilherme Artioli   +2 more
exaly   +3 more sources

Varied Effects of Carnosine and an Antioxidant-Enriched Carnosine Supplement in Paracetamol-Induced Hepatotoxicity Model in Mice [PDF]

Current Issues in Molecular Biology
Carnosine is widely recognized for its antioxidant and cytoprotective properties and is being increasingly used in dietary supplements. However, its effects in drug-induced liver injury remain insufficiently studied.
Dragana Zaklan, Nikola Martić, Bojana Andrejić Višnjić, Milana Bosanac, Snežana Hadžistević, Aleksandar Rašković, Nebojša Pavlović   +6 more
doaj   +2 more sources

Thermodynamic and voltammetric study on carnosine and ferrocenyl-carnosine

Dalton Transactions, 2023
An electroactive carnosine derivative (ferrocenyl-carnosine, FcCAR (L)) was synthesized and its complexing and sensing properties were evaluated; it was found to be promising for the electrochemical detection of Hg 2+ and Pb 2+ in an aqueous environment.
Chiara Abate, Anna Piperno, Alex Fragoso, Ottavia Giuffrè, Antonino Mazzaglia, Angela Scala, Claudia Foti   +6 more
openaire   +3 more sources

CARNOSINE-LOADED ORAL NIOSOMES AMELIORATE HIGH-FRUCTOSE-INDUCED METABOLIC SYNDROME IN RATS VIA MODULATION OF SIRT1, A METABOLIC MASTER SWITCH

Slovenian Veterinary Research, 2023
Metabolic syndrome is a crucial health challenge, and the available therapeutic agents are still not effective. Carnosine, a cytoplasmic dipeptide, is a potent anti-glycation, anti-oxidant, anti-inflammatory and chelating agent.
Amany I Ahmed, Nada Y. Nasr, Mahmoud A. Said, Reham H. Alattar, Khalifa El-Dawy   +4 more
doaj   +1 more source

Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a chronic autoimmune disease driven by sustained inflammation in the central nervous system. One of the pathological hallmarks of MS is extensive free radical production. However, the subsequent generation, potential
Jan Spaas, Wouter M. A. Franssen, Charly Keytsman, Laura Blancquaert, Tim Vanmierlo, Jeroen Bogie, Bieke Broux, Niels Hellings, Jack van Horssen, Dheeraj Kumar Posa, David Hoetker, Shahid P. Baba, Wim Derave, Bert O. Eijnde   +13 more
doaj   +1 more source

Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence

Molecules, 2022
The activity of the P-glycoprotein (P-gp) transporter encoded by the ABCB1 gene confers resistance to anticancer drugs and contributes to cancer-related mortality and morbidity.
Mohamed A. Morsy, Mahmoud Kandeel, Ahmed R. N. Ibrahim, Seham A. Abdel-Gaber, Shery Jacob, Katharigatta N. Venugopala, Pottathil Shinu, Mahmoud El-Daly   +7 more
doaj   +1 more source

Regulation of mitochondrial function and energy metabolism: A primary mechanism of cytoprotection provided by carnosine [PDF]

Trends in Pharmaceutical Sciences, 2018
Carnosine is an abundantly found dipeptide present in different tissues. Several pharmacological properties have been attributed to carnosine. On the other hand, the precise mechanism of cytoprotection provided by carnosine remains obscure.
Reza Heidari, Vahid Ghanbarinejad, Mohammad Mehdi Ommati, Akram Jamshidzadeh, Hossein Niknahad   +4 more
doaj   +3 more sources

Carnosine and bone (Review)

Molecular Medicine Reports, 2022
Carnosine is a vital endogenous dipeptide that has anti‑inflammatory, antiaging, anti‑crosslinking, antitumor and immune regulatory effects. Numerous cell and animal model studies have proved that carnosine and its compounds promote the proliferation and differentiation of osteoblasts, inhibit osteoclasts and protect chondrocytes.
Yang, Hao, Hou, Xiaoli, Xing, Lei, Tian, Faming   +3 more
openaire   +2 more sources