Results 1 to 10 of about 15,119 (225)

Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model [PDF]

Molecular Cancer, 2010
Background It was previously demonstrated that the dipeptide carnosine inhibits growth of cultured cells isolated from patients with malignant glioma.
Jan G Hengstler, Frank Gaunitz
exaly   +4 more sources

Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation

Antioxidants, 2021
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It is found in high concentrations in the brain, muscle, and gastrointestinal tissues of humans and is present in all vertebrates.
Ivana Jukic, Nikolina Kolobarić, Ana Stupin   +2 more
exaly   +3 more sources

Exercise and β-alanine supplementation on carnosine-acrolein adduct in skeletal muscle

Redox Biology, 2018
Previous studies have demonstrated that exercise results in reactive aldehyde production and that β-alanine supplementation increases carnosine content in skeletal muscle.
Paolo Di Mascio, Bruno Gualano, Guilherme G Artioli   +2 more
exaly   +3 more sources

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

Cells, 2019
Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition ...
Giuseppe Caruso, Nicolo' Musso, Margherita Grasso   +2 more
exaly   +3 more sources

CARNOSINE-LOADED ORAL NIOSOMES AMELIORATE HIGH-FRUCTOSE-INDUCED METABOLIC SYNDROME IN RATS VIA MODULATION OF SIRT1, A METABOLIC MASTER SWITCH

Slovenian Veterinary Research, 2023
Metabolic syndrome is a crucial health challenge, and the available therapeutic agents are still not effective. Carnosine, a cytoplasmic dipeptide, is a potent anti-glycation, anti-oxidant, anti-inflammatory and chelating agent.
Amany I Ahmed, Nada Y. Nasr, Mahmoud A. Said, Reham H. Alattar, Khalifa El-Dawy   +4 more
doaj   +1 more source

Regulation of mitochondrial function and energy metabolism: A primary mechanism of cytoprotection provided by carnosine [PDF]

Trends in Pharmaceutical Sciences, 2018
Carnosine is an abundantly found dipeptide present in different tissues. Several pharmacological properties have been attributed to carnosine. On the other hand, the precise mechanism of cytoprotection provided by carnosine remains obscure.
Reza Heidari, Vahid Ghanbarinejad, Mohammad Mehdi Ommati, Akram Jamshidzadeh, Hossein Niknahad   +4 more
doaj   +3 more sources

Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a chronic autoimmune disease driven by sustained inflammation in the central nervous system. One of the pathological hallmarks of MS is extensive free radical production. However, the subsequent generation, potential
Jan Spaas, Wouter M. A. Franssen, Charly Keytsman, Laura Blancquaert, Tim Vanmierlo, Jeroen Bogie, Bieke Broux, Niels Hellings, Jack van Horssen, Dheeraj Kumar Posa, David Hoetker, Shahid P. Baba, Wim Derave, Bert O. Eijnde   +13 more
doaj   +1 more source

Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence

Molecules, 2022
The activity of the P-glycoprotein (P-gp) transporter encoded by the ABCB1 gene confers resistance to anticancer drugs and contributes to cancer-related mortality and morbidity.
Mohamed A. Morsy, Mahmoud Kandeel, Ahmed R. N. Ibrahim, Seham A. Abdel-Gaber, Shery Jacob, Katharigatta N. Venugopala, Pottathil Shinu, Mahmoud El-Daly   +7 more
doaj   +1 more source

Thermodynamic and voltammetric study on carnosine and ferrocenyl-carnosine

Dalton Transactions, 2023
An electroactive carnosine derivative (ferrocenyl-carnosine, FcCAR (L)) was synthesized and its complexing and sensing properties were evaluated; it was found to be promising for the electrochemical detection of Hg2+and Pb2+in an aqueous environment.
Chiara Abate, Anna Piperno, Alex Fragoso, Ottavia Giuffrè, Antonino Mazzaglia, Angela Scala, Claudia Foti   +6 more
openaire   +3 more sources

Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Muscle wasting during cancer cachexia is mediated by protein degradation via autophagy and ubiquitin‐linked proteolysis. These processes are sensitive to changes in intracellular pH ([pH]i) and reactive oxygen species, which in skeletal muscle
Dheeraj Kumar Posa, Janice Miller, David Hoetker, Michael I. Ramage, Hong Gao, Jingjing Zhao, Benjamin Doelling, Aruni Bhatnagar, Stephen J. Wigmore, Richard J.E. Skipworth, Shahid P. Baba   +10 more
doaj   +1 more source