Results 1 to 10 of about 10,570 (207)

The Role and Mechanism of Carnosine in Alleviating Type 2 Diabetic Sarcopenia in Mice Through PI3K/AMPK/PGC-1α Signaling Pathway [PDF]

Biology
Type 2 diabetes mellitus (T2DM) accounts for over 90% of diabetes cases, and T2DM-related sarcopenia is a growing concern. Carnosine, abundant in human skeletal muscle, helps maintain muscle quality and function. This study investigated whether carnosine
Xiang Li, Bo Tian, Yuxin Chen, Huili Tong, Xiaoming Chen, Zhifeng Cheng   +5 more
doaj   +2 more sources

Periodontitis-Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine-Mediated Acidosis Adaptation. [PDF]

Cell Prolif
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Wu R, Cai Z, Sun H, Yu H, Zhang B, Zhang C, Fan Y, Zhu X, Ni Y, Cui Y, Wang K, Li Z, Zhou X, He Q, Wu Y, Zhang Y.   +15 more
europepmc   +2 more sources

Exercise and β-alanine supplementation on carnosine-acrolein adduct in skeletal muscle

Redox Biology, 2018
Previous studies have demonstrated that exercise results in reactive aldehyde production and that β-alanine supplementation increases carnosine content in skeletal muscle.
Bruno Gualano, Luana Farias de Oliveira, Guilherme Artioli   +2 more
exaly   +3 more sources

Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial [PDF]

Journal of the International Society of Sports Nutrition
Background Carnosine (β-alanine-L-histidine) is an endogenous dipeptide found in abundance in highly metabolic tissues such as skeletal muscle and the brain, where it is thought to play a role in intracellular buffering, and thereby, promote anaerobic ...
Timothy E. O'Toole, Christopher J. Wingard, Sonja K. Bariess, Catherine E. Crandell, Alok R. Amraotkar, Hong Gao, Aruni Bhatnagar   +6 more
doaj   +2 more sources

Evaluation of supplementary carnosine accumulation and distribution: an initial analysis of participants in the Nucleophilic Defense Against PM Toxicity (NEAT) clinical trial

Amino Acids
Carnosine is an endogenous dipeptide that buffers intracellular pH and quenches toxic products of lipid peroxidation. Used as a dietary supplement, it also supports exercise endurance.
Timothy O'Toole, David Hoetker, Peter J Rice   +2 more
exaly   +2 more sources

Varied Effects of Carnosine and an Antioxidant-Enriched Carnosine Supplement in Paracetamol-Induced Hepatotoxicity Model in Mice [PDF]

Current Issues in Molecular Biology
Carnosine is widely recognized for its antioxidant and cytoprotective properties and is being increasingly used in dietary supplements. However, its effects in drug-induced liver injury remain insufficiently studied.
Dragana Zaklan, Nikola Martić, Bojana Andrejić Višnjić, Milana Bosanac, Snežana Hadžistević, Aleksandar Rašković, Nebojša Pavlović   +6 more
doaj   +2 more sources

Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation

Antioxidants, 2021
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It is found in high concentrations in the brain, muscle, and gastrointestinal tissues of humans and is present in all vertebrates.
Ivana Jukić, Nikolina Kolobarić, Ana Stupin, Anita Matić, Nataša Kozina, Zrinka Mihaljević, Martina Mihalj, Petar Šušnjara, Marko Stupin, Željka Breškić Ćurić, Kristina Selthofer-Relatić, Aleksandar Kibel, Anamarija Lukinac, Luka Kolar, Gordana Kralik, Zlata Kralik, Aleksandar Széchenyi, Marija Jozanović, Olivera Galović, Martina Medvidović-Kosanović, Ines Drenjančević   +20 more
doaj   +1 more source

CARNOSINE-LOADED ORAL NIOSOMES AMELIORATE HIGH-FRUCTOSE-INDUCED METABOLIC SYNDROME IN RATS VIA MODULATION OF SIRT1, A METABOLIC MASTER SWITCH

Slovenian Veterinary Research, 2023
Metabolic syndrome is a crucial health challenge, and the available therapeutic agents are still not effective. Carnosine, a cytoplasmic dipeptide, is a potent anti-glycation, anti-oxidant, anti-inflammatory and chelating agent.
Amany I Ahmed, Nada Y. Nasr, Mahmoud A. Said, Reham H. Alattar, Khalifa El-Dawy   +4 more
doaj   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a chronic autoimmune disease driven by sustained inflammation in the central nervous system. One of the pathological hallmarks of MS is extensive free radical production. However, the subsequent generation, potential
Jan Spaas, Wouter M. A. Franssen, Charly Keytsman, Laura Blancquaert, Tim Vanmierlo, Jeroen Bogie, Bieke Broux, Niels Hellings, Jack van Horssen, Dheeraj Kumar Posa, David Hoetker, Shahid P. Baba, Wim Derave, Bert O. Eijnde   +13 more
doaj   +1 more source