Results 1 to 10 of about 6,763 (184)

Carnosine Activates Cellular Stress Response in Podocytes and Reduces Glycative and Lipoperoxidative Stress

Biomedicines, 2020
Carnosine improves diabetic complications, including diabetic nephropathy, in in vivo models. To further understand the underlying mechanism of nephroprotection, we studied the effect of carnosine under glucose-induced stress on cellular stress response ...
Maria Scuto, Angela Trovato Salinaro, Sergio Modafferi, Alessandra Polimeni, Tilman Pfeffer, Tim Weigand, Vittorio Calabrese, Claus Peter Schmitt, Verena Peters   +8 more
doaj   +1 more source

Combined Anserine/Carnosine Exerts Anti‐Hyperuricemic, Nephroprotective, and Gut Microbiota‐Modulating Effects in Hyperuricemia Mice

Food Bioengineering, Volume 5, Issue 2, Page 194-208, June 2026.
Mixed carnosine and anserine significantly reduce serum uric acid, protect the kidneys, and modulate gut microbiota, demonstrating potent therapeutic potential against hyperuricemia. ABSTRACT The anti‐hyperuricemic, nephroprotective, and gut microbiota modulation effects of mixed carnosine and anserine (MAC) with the fixed ratio of 10:1 were evaluated ...
Jingjing Huang, Zheng Dang, Yuzhi Zhang, Haisheng Lin, Lei Du, Jie Zhang, Li Zhao, William T. H. Chang, Xiang‐Ru Kong, Wei‐Ting Tseng, Jingli Xie   +10 more
wiley   +1 more source

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

Cells, 2019
Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition ...
Giuseppe Caruso, Claudia G. Fresta, Nicolò Musso, Mariaconcetta Giambirtone, Margherita Grasso, Simona F. Spampinato, Sara Merlo, Filippo Drago, Giuseppe Lazzarino, Maria A. Sortino, Susan M. Lunte, Filippo Caraci   +11 more
doaj   +1 more source

Microalgae Oil Attenuates Liver Fat Deposition in NAFLD via Modulation of Anti‐Lipogenic Genes and Insulin Signaling Pathways in HFD Mice

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Dietary microalgae oil might reverse hepatic lipid deposition in a mouse model of fatty liver. This intervention significantly improves the overall fatty liver condition by reducing lipid accumulation and simultaneously restoring insulin sensitivity. ABSTRACT Non‐alcoholic fatty liver disease (NAFLD) is a leading cause of liver‐related mortality and ...
Athba AlQahtani, Mingjie Wang, Liping Liu, Liyuan Ran, Chao Liu, Yun Liang, Jinhui Yu, Yingjie Wu, Qingbo Guan   +8 more
wiley   +1 more source

Evaluation of the Transepidermal Penetration of a Carnosine Complex in Gel Formulation by 3D Skin Models

Cosmetics, 2018
Carnosine has several physiological roles, from intracellular pH buffering to antioxidant activities, which all depend on bioavailability. This study was conducted in a human skin 3D model and focuses on the effects of the topical delivery of carnosine ...
Valeria Dissette, Carlo Alberto Bignozzi, Giuseppe Valacchi, Alessandra Pecorelli, Stefano Manfredini, Silvia Vertuani   +5 more
doaj   +1 more source

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi, Giulia Gentili, Laura Salvadori, Martina Paiella, Marcello Manfredi, Vittoria Federica Borrini, Kaamashri Mangar, Ann Marie Schmidt, Maurizio Muscaritoli, Francesca Riuzzi, Guglielmo Sorci   +10 more
wiley   +1 more source

Carnosine Ameliorates Stress-Induced Glucose Metabolism Disorder in Restrained Mice

Journal of Pharmacological Sciences, 2011
.: Carnosine is a natural dipeptide that has shown multiple benefits in the treatment of various diseases. This study investigated the ameliorative effects of carnosine on glucose metabolism in restraint-stressed mice.
Bun Tsoi, Rong-Rong He, Dong-Hui Yang, Yi-Fang Li, Xiao-Di Li, Wei-Xi Li, Keiichi Abe, Hiroshi Kurihara   +7 more
doaj   +1 more source

Determinants of muscle carnosine content [PDF]

Amino Acids, 2012
The main determinant of muscle carnosine (M-Carn) content is undoubtedly species, with, for example, aerobically trained female vegetarian athletes [with circa 13 mmol/kg dry muscle (dm)] having just 1/10th of that found in trained thoroughbred horses.
Harris, R. C., Wise, J. A., Price, K. A., Kim, H. J., Kim, C. K., Sale, C.   +5 more
openaire   +2 more sources

Post‐Inflammatory Hyperpigmentation: Molecular Mechanisms and Advances in Dermocosmetic Management

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Post‐inflammatory hyperpigmentation (PIH) is a condition that causes skin pigmentation after acute or chronic inflammation. It affects people with darker skin tones more than others, especially Asians (Fitzpatrick types III–VI), and can last for months or even years, making life much less enjoyable.
Rui Li, Baiyu Li, Qilin Zhang, Chunyu Zhao, Caixia Ye, Yang Chen, Claire Huguet, Wei Xiong, Valentine Beguin, Delphine Kerob, Yijie Zheng   +10 more
wiley   +1 more source

Treatment of Acne‐Induced Facial Post‐Inflammatory Hyperpigmentation With a New 2‐MNG‐Containing Routine Versus a Thiamidol‐Containing Routine—A Monocentric Prospective Double‐Blind Randomized Comparative Trial

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Acne‐induced post‐inflammatory hyperpigmentation (PIHP) is a frequent condition. 2‐mercaptonicotinoyl glycine (2‐MNG) is an innovative anti‐pigmenting molecule. Aims The aim of this study is to compare the efficacy and tolerability of two routines in the treatment of PIHP: 2‐MNG‐containing serum + SPF50+/UVA sunscreen versus ...
Thierry Passeron, Guénaëlle Le Dantec, Samir Salah, Beatrice Marie, Kate Randamy, Kim T. F. C. Dhin‐Kien, Ann' Laure Demessant‐Flavigny, Andrew Alexis   +7 more
wiley   +1 more source