Results 21 to 30 of about 6,763 (184)
Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Muscle wasting during cancer cachexia is mediated by protein degradation via autophagy and ubiquitin‐linked proteolysis. These processes are sensitive to changes in intracellular pH ([pH]i) and reactive oxygen species, which in skeletal muscle
Dheeraj Kumar Posa +10 more
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PLoS ONE, 2020 Carnosine is a naturally occurring histidine-containing dipeptide present at high concentration in mammalian skeletal muscles. Carnosine was shown to affect muscle contraction, prevent the accumulation of oxidative metabolism by-products and act as an ...
Marie-France Palin +4 more
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Carnosine in health and disease [PDF]
European Journal of Sport Science, 2018 AbstractCarnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of ...
Artioli, GG, Sale, C, Jones, RL
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Evaluation of Antidiabetic and Antioxidant Activities of L-carnosine using Enzyme Inhibition and Free Radical Scavenging Assays: An In-vitro Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Diabetes is a chronic disease that causes dysfunction of various organs and tissues resulting in end organ damage and premature mortality. Oxidative stress is a main factor of diabetic complications.
D Malathy +3 more
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Carnosine and cancer: a perspective [PDF]
Amino Acids, 2012 The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination. In the present perspective, a possible use of carnosine as an anti-neoplastic therapeutic, especially for the treatment of malignant brain tumours such as glioblastoma ...
Frank, Gaunitz, Alan R, Hipkiss
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Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal
Cellular Physiology and Biochemistry, 2018 Background/Aims: Reactive dicarbonyl compounds, such as methylglyoxal (MG), contribute to diabetic complications. MG-scavenging capacities of carnosine and anserine, which have been shown to mitigate diabetic nephropathy, were evaluated in vitro and in ...
Tim Weigand +14 more
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Biomedicines, 2021 Carnosine is a natural occurring endogenous dipeptide that was proposed as an anti-aging agent more than 20 years ago. Carnosine can be found at low millimolar concentrations at brain level and different preclinical studies have demonstrated its ...
Giuseppe Caruso +8 more
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Анналы клинической и экспериментальной неврологии, 2017 We investigated the protective effect of carnosine (carnosine-containing nanoliposomes and newly synthesized S-trolox-carnosine) in experiments in vivo on a model of acute hypobaric hypoxia in rodents and in vitro on neuronal cultures under oxidative ...
T. N. Fedorova +6 more
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Agriculture, 2022 (1) Background: L-carnosine (β-alanyl-L-histidine), a natural dipeptide, exists at relatively high concentrations in skeletal muscles, and has been shown to protect cells from adverse conditions due to its antioxidant, anti-aging, anti-glycation, and ...
Yaojun Liu +10 more
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Carnosine inhibits the proliferation of human gastric cancer SGC-7901 cells through both of the mitochondrial respiration and glycolysis pathways. [PDF]
PLoS ONE, 2014 Carnosine, a naturally occurring dipeptide, has been recently demonstrated to possess anti-tumor activity. However, its underlying mechanism is unclear.
Yao Shen +6 more
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