Results 21 to 30 of about 6,822 (183)

Improved Satellite Cell Proliferation Induced by L-Carnosine Benefits Muscle Growth of Pigs in Part through Activation of the Akt/mTOR/S6K Signaling Pathway

Agriculture, 2022
(1) Background: L-carnosine (β-alanyl-L-histidine), a natural dipeptide, exists at relatively high concentrations in skeletal muscles, and has been shown to protect cells from adverse conditions due to its antioxidant, anti-aging, anti-glycation, and ...
Yaojun Liu, Wenqiang Shen, Tao Liu, Rainer Mosenthin, Yinghui Bao, Peng Chen, Wenbo Hao, Lihong Zhao, Jianyun Zhang, Cheng Ji, Qiugang Ma   +10 more
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Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization

Frontiers in Physiology, 2019
High (millimolar) concentrations of the histidine containing dipeptide – carnosine (β-alanine-L-histidine) are present in the skeletal muscle. The dipeptide has been shown to buffer intracellular pH, chelate transition metals, and scavenge lipid ...
Adjoa A. Boakye, Deqing Zhang, Deqing Zhang, Luping Guo, Luping Guo, Yuting Zheng, Yuting Zheng, David Hoetker, David Hoetker, Jingjing Zhao, Jingjing Zhao, Dheeraj Kumar Posa, Dheeraj Kumar Posa, Chin K. Ng, Huaiyu Zheng, Amit Kumar, Vijay Kumar, Michael F. Wempe, Aruni Bhatnagar, Aruni Bhatnagar, Daniel J. Conklin, Daniel J. Conklin, Shahid P. Baba, Shahid P. Baba   +23 more
doaj   +1 more source

Anti-stress effects of carnosine on restraint-evoked immunocompromise in mice through spleen lymphocyte number maintenance. [PDF]

PLoS ONE, 2012
Carnosine (β-alanyl-L-histidine), a naturally occurring dipeptide, has been characterized as a putative neurotransmitter and serves as a reservoir for brain histamine, which could act on histaminergic neurons system to relieve stress-induced damages ...
Yi-Fang Li, Rong-Rong He, Bun Tsoi, Xiao-Di Li, Wei-Xi Li, Keiichi Abe, Hiroshi Kurihara   +6 more
doaj   +1 more source

Carnosine attenuates vascular smooth muscle cells calcification through mTOR signaling pathway

Aging Medicine, 2020
Objective Vascular calcification is prevalent in the aging population, as we know that arterial calcification is associated with aging. Recent studies have demonstrated that carnosine, a naturally occurring dipeptide, performs the treatment of aging ...
Yi Huang, Jinli Wang, Mandi Luo, Dan Yan, Cuntai Zhang   +4 more
doaj   +1 more source

L-Carnosine Stimulation of Coenzyme Q10 Biosynthesis Promotes Improved Mitochondrial Function and Decreases Hepatic Steatosis in Diabetic Conditions

Antioxidants, 2021
Mitochondrial dysfunction in type 2 diabetes leads to oxidative stress, which drives disease progression and diabetes complications. L-carnosine, an endogenous dipeptide, improves metabolic control, wound healing and kidney function in animal models of ...
Cheng Schwank-Xu, Elisabete Forsberg, Magnus Bentinger, Allan Zhao, Ishrath Ansurudeen, Gustav Dallner, Sergiu-Bogdan Catrina, Kerstin Brismar, Michael Tekle   +8 more
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Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model

Molecular Cancer, 2010
Background It was previously demonstrated that the dipeptide carnosine inhibits growth of cultured cells isolated from patients with malignant glioma.
Meixensberger Jürgen, Gebhardt Rolf, Hengstler Jan, Hermes Matthias, Geiger Kathrin D, Fuchs Beate, Zemitzsch Nadine, Renner Christof, Gaunitz Frank   +8 more
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Genetic Polymorphisms of Carnosine Synthase -1(ATPGD1) and Serum Carnosine Levels in Relation to Cardiovascular Diseases in Iraqi Type 2 Diabetics

Iraqi Journal of Pharmaceutical Sciences
Diabetes mellitus (DM) is a metabolic disorder specified by persistent hyperglycemia that occurs when β-cell insulin production became unable to control blood glucose with deterioration of response for insulin.
Haneen Subhee Shaheed, Shatha H Ali
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Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?

Frontiers in Nutrition, 2019
Carnosine is an abundant histidine-containing dipeptide in human skeletal muscle and formed by beta-alanine and L-histidine. It performs various physiological roles during exercise and has attracted strong interest in recent years with numerous ...
Pedro Perim, Felipe Miguel Marticorena, Felipe Ribeiro, Gabriel Barreto, Nathan Gobbi, Chad Kerksick, Eimear Dolan, Bryan Saunders, Bryan Saunders   +8 more
doaj   +1 more source

Investigation of Dose-Related Effects of Carnosine on Anxiety with Sympathetic Skin Response and T-maze

Acta Medica, 2014
Carnosine is a dipeptide formed of the amino acids β-alanine and histidine. Only a limited number of studies have examined the effects of carnosine on sympathetic nerve activation and anxiety.
Nazan Dolu, Hale Acer, Ali Yucel Kara
doaj   +1 more source

Evaluation of supplementary carnosine accumulation and distribution: an initial analysis of participants in the Nucleophilic Defense Against PM Toxicity (NEAT) clinical trial

Amino Acids
Carnosine is an endogenous dipeptide that buffers intracellular pH and quenches toxic products of lipid peroxidation. Used as a dietary supplement, it also supports exercise endurance.
Shahid P. Baba, Alok R. Amraotkar, David Hoetker, Hong Gao, Daniel Gomes, Jingjing Zhao, Michael F. Wempe, Peter J. Rice, Andrew P. DeFilippis, Shesh N. Rai, C. Arden Pope, Aruni Bhatnagar, Timothy E. O’Toole   +12 more
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