Results 41 to 50 of about 15,119 (225)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition [PDF]

, 2015
Although the prevalence of malnutrition in the old age is increasing worldwide a synthetic understanding of the impact of aging on the intake, digestion, and absorption of nutrients is still lacking.
Bordoni, Alessandra, Dupont, Didier, Gille, Doreen, Kachal, Josefa, Peyron, Marie-Agnès, Pinto, Paula, Rémond, Didier., Santos, Claudia Nunes Dos, Shahar, Danit R., Tomás-Cobos, Lidia, Vergères, Guy, Walther, Barbara   +11 more
core   +4 more sources

Carnosine in health and disease [PDF]

European Journal of Sport Science, 2018
AbstractCarnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of ...
Artioli, GG, Sale, C, Jones, RL
openaire   +3 more sources

Genetic Polymorphisms of Carnosine Synthase -1(ATPGD1) and Serum Carnosine Levels in Relation to Cardiovascular Diseases in Iraqi Type 2 Diabetics

Iraqi Journal of Pharmaceutical Sciences
Diabetes mellitus (DM) is a metabolic disorder specified by persistent hyperglycemia that occurs when β-cell insulin production became unable to control blood glucose with deterioration of response for insulin.
Haneen Subhee Shaheed, Shatha H Ali
doaj   +1 more source

CARNOSINE-CONTAINING LIPOSOMES: PREPARATION AND PROPERTIES

Тонкие химические технологии, 2016
Carnosine is a natural dipeptide antioxidant. It is proved that it protects human’s cells from oxidative stress. However, it has a short lifetime in a human organism due to the carnosinase activity.
N. A. Antonova, G. M. Sorokoumova, T. N. Fedorova, S. L. Stvolynsky, D. A. Abaimov, V. I. Popenko, V. I. Shvets   +6 more
doaj   +1 more source

Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?

Frontiers in Nutrition, 2019
Carnosine is an abundant histidine-containing dipeptide in human skeletal muscle and formed by beta-alanine and L-histidine. It performs various physiological roles during exercise and has attracted strong interest in recent years with numerous ...
Pedro Perim, Felipe Miguel Marticorena, Felipe Ribeiro, Gabriel Barreto, Nathan Gobbi, Chad Kerksick, Eimear Dolan, Bryan Saunders, Bryan Saunders   +8 more
doaj   +1 more source

Carnosine and cancer: a perspective [PDF]

Amino Acids, 2012
The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination. In the present perspective, a possible use of carnosine as an anti-neoplastic therapeutic, especially for the treatment of malignant brain tumours such as glioblastoma ...
Frank, Gaunitz, Alan R, Hipkiss
openaire   +2 more sources

Evaluation of supplementary carnosine accumulation and distribution: an initial analysis of participants in the Nucleophilic Defense Against PM Toxicity (NEAT) clinical trial

Amino Acids
Carnosine is an endogenous dipeptide that buffers intracellular pH and quenches toxic products of lipid peroxidation. Used as a dietary supplement, it also supports exercise endurance.
Shahid P. Baba, Alok R. Amraotkar, David Hoetker, Hong Gao, Daniel Gomes, Jingjing Zhao, Michael F. Wempe, Peter J. Rice, Andrew P. DeFilippis, Shesh N. Rai, C. Arden Pope, Aruni Bhatnagar, Timothy E. O’Toole   +12 more
doaj   +1 more source

Differences in muscle histidine‐containing dipeptides in broilers [PDF]

, 2019
BACKGROUND: Poultry meat has high levels of histidine-containing dipeptides (HCD) and consumption of meat rich in HCD may elicit certain health benefits. The aim of this work was to compare the HCD content (anserine and carnosine) in the breast and thigh
Barbaresi, Silvia, Claeys, Erik, De Smet, Stefaan, Derave, Wim, Maertens, Luc   +4 more
core   +2 more sources

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

PEGylation renders carnosine resistant to hydrolysis by serum carnosinase and increases renal carnosine levels

Amino Acids
Carnosine’s protective effect in rodent models of glycoxidative stress have provided a rational for translation of these findings in therapeutic concepts in patient with diabetic kidney disease.
Shiqi Zhang, Guang Yang, Qinqin Zhang, Yuying Fan, Mingna Tang, Liuhai Shen, Dongchun Zhu, Guiyang Zhang, Benito Yard   +8 more
doaj   +1 more source