Results 61 to 70 of about 10,570 (207)
Frontiers in PharmacologyOral consumption of histidyl dipeptides such as l-carnosine has been suggested to promote cardiometabolic health, although therapeutic mechanisms remain incompletely understood.
Islam A. Berdaweel +13 more
doaj +1 more source
Cells, 2019 Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition ...
Giuseppe Caruso +11 more
doaj +1 more source
Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells
The FEBS Journal, EarlyView.MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe +5 more
wiley +1 more source
Carnosine and related dipeptides as quenchers of reactive carbonyl species
, 2011 Carnosine (beta-alanyl-L-histidine, CAR) and related peptides are histidine-containing dipeptides particularly abundant in excitable tissues such as nervous system and skeletal muscle.
G. Aldini, M. Orioli, M. Carini
core +2 more sources
Integrative Cancer Therapies, 2018 Carnosine has been demonstrated to play an antitumorigenic role in certain types of cancer. However, its underlying mechanism is unclear. In this study, the roles of carnosine in cell proliferation and its underlying mechanism were investigated in the ...
Yun Bao MS +7 more
doaj +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Bacteriophages impact soil bacteria through lysis, altering the availability of organic carbon and plant nutrients. However, the magnitude of nutrient uptake by plants from lysed bacteria remains unknown, partly because this process is challenging to investigate in the field.
Vlastimil Novak +10 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend There has been controversy about the structural (capillary) response of skeletal muscle to altered O2 status, involving decreased supply (hypoxia) or increased demand (activity). Here we demonstrate that seven days of activation of skeletal muscle by indirect electrical stimulation led to significant expansion of the capillary ...
David Hauton +3 more
wiley +1 more source
Carnosine as a histidine source: Transport and hydrolysis of exogeneous carnosine by rat intestine.
Journal of Nutritional Science and Vitaminology, 1985 Transport and metabolism of L-carnosine (beta-alanyl-L-histidine) were studied in rat small intestine. Carnosine administered orally was found in rat serum as well as small intestine and liver, followed by an increase of histidine. At ten minutes after carnosine infusion per os, the carnosine content of the hepatic portal vein increased with the dose ...
TAMAKI, Nanaya +3 more
openaire +3 more sources
Determinants of muscle carnosine content [PDF]
Amino Acids, 2012 The main determinant of muscle carnosine (M-Carn) content is undoubtedly species, with, for example, aerobically trained female vegetarian athletes [with circa 13 mmol/kg dry muscle (dm)] having just 1/10th of that found in trained thoroughbred horses.
Harris, R. C. +5 more
openaire +2 more sources
Cosmetics, 2018 Carnosine has several physiological roles, from intracellular pH buffering to antioxidant activities, which all depend on bioavailability. This study was conducted in a human skin 3D model and focuses on the effects of the topical delivery of carnosine ...
Valeria Dissette +5 more
doaj +1 more source