Results 61 to 70 of about 6,822 (183)

MIF‐MAPMS: Enhancing identification of myelin autoantigenic peptides in multiple sclerosis through multimodal information fusion

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Multiple sclerosis (MS) arises from an autoimmune response in which the immune system erroneously targets myelin autoantigens within the central nervous system, leading to myelin degradation and subsequent neurological dysfunction. Identifying myelin autoantigenic peptides (MAPs) is therefore critical for understanding MS pathogenesis and ...
Watshara Shoombuatong, Nalini Schaduangrat, Pramote Chumnanpuen, Lawankorn Mookdarsanit, Pakpoom Mookdarsanit   +4 more
wiley   +1 more source

The Pharmacology of the SLC15A4‐TASL Complex, an Emerging Target for the Treatment of Lupus

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT SLC15A4 is a member of the solute carrier superfamily that has been strongly linked to the pathogenesis of the auto‐immune disease SLE. The endo‐lysosomally localized SLC15A4 has traditionally been considered a proton‐dependent histidine and peptide transporter, but has also been shown to facilitate TLR7, 8, and 9 induced IFN‐alpha signaling ...
Alex L. Wilkinson, Dillon Popat, Kathy Sengmany, Miguel C. Silva, Steven J. Charlton, Charles S. Lay   +5 more
wiley   +1 more source

Carnosine‐Related Metabolism in Rat Cardiomyocytes and Human Heart Tissue

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Carnosine‐related metabolism in rat cardiomyocytes and human heart tissue. Jade V Creighton, Lívia de Souza Gonçalves, Saulo Gil, Bianca Scigliano Vargas, Leonardo Jensen, Marisa Helena Gennari de Medeiros, Hamilton Roschel, Mark D Turner, Craig L Doig, Guilherme Giannini Artioli, Craig Sale.
Jade V. Creighton, Lívia de Souza Gonçalves, Saulo Gil, Bianca Scigliano Vargas, Leonardo Jensen, Marisa Helena Gennari de Medeiros, Hamilton Roschel, Mark D. Turner, Craig L. Doig, Guilherme Giannini Artioli, Craig Sale   +10 more
wiley   +1 more source

Carnosine suppresses neuronal cell death and inflammation induced by 6-hydroxydopamine in an in vitro model of Parkinson's disease.

PLoS ONE, 2020
Parkinson's disease is a progressive neurodegenerative disease for which prevention and effective treatments are lacking. The pathogenesis of Parkinson's disease is not clearly understood.
Maho Kubota, Nahoko Kobayashi, Toshifumi Sugizaki, Mikako Shimoda, Masahiro Kawahara, Ken-Ichiro Tanaka   +5 more
doaj   +1 more source

Tracking COVID‐19 Severity and Progression Through Amines and Lipid Mediators

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) exhibits a broad spectrum of severity, ranging from mild to critical cases. To reduce mortality and costs, tailored early interventions for at‐risk patients are essential. This study elucidates the association between longitudinal metabolomic profiles and COVID‐19 severity and progression.
Melissa Goris, Merys Valdez, Lieke Lamont, Wei Yang, Amy Harms, Naama Karu, Sabine Bos, Jelte Geerlings, Tom Ottenhoff, Roula Tsonaka, Anna HE Roukens, M. Sesmu Arbous, Simone A. Joosten, Thomas Hankemeier, Alida Kindt, In collaboration with BEAT‐COVID group, M.S. Arbous, B.M. van den Berg, S. Cannegieter, C.M. Cobbaert, A. van der Does, J.J.M. van Dongen, J. Eikenboom, M.C.M. Feltkamp, A. Geluk, J.J. Goeman, M. Giera, T. Hankemeier, M.H.M. Heemskerk, P.S. Hiemstra, C.H. Hokke, J.J. Janse, S.P. Jochems, S.A. Joosten, M. Kikkert, L. Lamont, J. Manniën, T.H.M. Ottenhoff, M.R. del Prado, N. Queralt Rosinach, M. Roestenberg, M. Roos, A.H.E. Roukens, H.H. Smits, E.J. Snijder, F.J.T. Staal, L.A. Trouw, R. Tsonaka, A. Verhoeven, L.G. Visser, J.J.C. de Vries, D.J. van Westerloo, J. Wigbers, H.J. van der Wijk, R.C. van Wissen, M. Wuhrer, M. Yazdanbakhsh, M. Zlei   +57 more
wiley   +1 more source

Dietary Supplementation of Rumen‐Inert Fatty Acids and Rumen‐Protected Choline Modulates the Uterine Environment of Pregnant Beef Cows

Molecular Reproduction and Development, Volume 93, Issue 7, July 2026.
This graphical abstract summarizes that dietary supplementation of pregnant beef cows with unsaturated fatty acids and choline can increase (green) the concentration of metabolites in the uterine luminal fluid and alter the endometrial epithelial transcriptome during the peri‐elongation period (upregulation = green and downregulation = red).
Megan Bahr, Allyson McCarty, Zaeem Sarwar, Damon Smith, Matt Poore, Daniel Poole, Nadia Ashrafi, Romana Mimi, Stewart Graham, Ky Pohler, Jose Santos, Christian Maltecca, Felipe A. C. C. Silva   +12 more
wiley   +1 more source

Anti-aggregating effect of the naturally occurring dipeptide carnosine on aβ1-42 fibril formation.

PLoS ONE, 2013
Carnosine is an endogenous dipeptide abundant in the central nervous system, where by acting as intracellular pH buffering molecule, Zn/Cu ion chelator, antioxidant and anti-crosslinking agent, it exerts a well-recognized multi-protective homeostatic ...
Alessandra Aloisi, Amilcare Barca, Alessandro Romano, Sara Guerrieri, Carlo Storelli, Rosaria Rinaldi, Tiziano Verri   +6 more
doaj   +1 more source

Effects of Carnosine on the Toxicity of Doxorubicin in Rabbits and Mice

Pteridines, 2003
The aim of this study was to establish the effect of naturally occurring antioxidant - carnosine - on the doxorubicin induced cardiotoxicity in a rabbit model.
Zieba Remigiusz, Czarnecka Elzbieta, Wągrowska-Danilewicz Małgorzata, Dzielska-Olczak Malgorzata, Graczyk Julita   +4 more
doaj   +1 more source

Revealing the global mechanism related to carnosine synthesis in the pectoralis major of slow-growing Korat chickens using a proteomic approach [PDF]

Animal Bioscience
Objective This study aimed to find global mechanisms related to carnosine synthesis in slow-growing Korat chickens (KRC) using a proteomic approach. Methods M.
Panpradub Sinpru, Chanadda Suwanvichanee, Rujjira Bunnom, Satoshi Kubota, Jirawat Yongsawatdigul, Wittawat Molee, Kanjana Thumanu, Amonrat Molee   +7 more
doaj   +1 more source

Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling.

PLoS ONE, 2019
Glioblastoma is a high-grade glioma with poor prognosis even after surgery and standard therapy. Here, we asked whether carnosine (β-alanyl-L-histidine), a naturally occurring dipeptide, exert its anti-neoplastic effect on glioblastoma cells via PI3K/Akt/
Henry Oppermann, Helene Faust, Ulrike Yamanishi, Jürgen Meixensberger, Frank Gaunitz   +4 more
doaj   +1 more source