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Inflammation mediates the effect of histidine on a lower risk of colorectal cancer [PDF]

Frontiers in Nutrition
BackgroundWhether anti-inflammatory mechanisms mediate the protective effects of histidine against colorectal carcinogenesis remains unexplored. We aimed to assess the association between plasma histidine and colorectal cancer (CRC) and to evaluate the ...
Chunlei He, Yudan Yang, Yudan Yang, Shuhui Chen, Bin Liu, Jing Guo, Ding Ye, Xiaohui Sun, Yingying Mao, Jiayu Li   +9 more
doaj   +2 more sources

Tautomerism in Neutral Histidine

Angewandte Chemie - International Edition, 2014
AbstractHistidine is an important natural amino acid, involved in many relevant biological processes, which, because of its physical properties, proved difficult to characterize experimentally in its neutral form. In this work, neutral histidine has been generated in the gas phase by laser ablation of solid samples and its NεH tautomeric form unraveled
C Bermudez, Santiago Mata, Carlos Cabezas   +2 more
exaly   +4 more sources

Global regulation and virulence mediated by the histidine-responsive local transcription factor HutC in Pseudomonas aeruginosa [PDF]

mBio
Host-derived nutritional substrates fuel infection in invading bacteria, yet their potential as signaling molecules for host perception remains largely unexplored.
Kiran S. Jayan, Naran Naren, Yunhao Liu, Xinyi Liu, Chang Luan, Xue-Xian Zhang   +5 more
doaj   +2 more sources

Histidine Metabolic Pathway Modifies the Relationships Between 6:2 Cl-PFESA Exposure and Preterm Birth [PDF]

Toxics
Background: Evidence linking chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) to preterm birth (PTB) is limited, and their relationships with the metabolome remain unexplored. Aims: Our study aimed to explore the role of the metabolome in the
Jianping Cong, Chu Chu, Zhitao Zhang, Gaoyuan Sun, Yan Zhang, Aaron M. Qian, Michael G. Vaughn, Sarah Dee Geiger, Kun Zhao, Yunting Zhang, Yang Zhou, Zhihua Yin, Guanghui Dong   +12 more
doaj   +2 more sources

Electrochemical Shell-Isolated Nanoparticle-Enhanced Raman Spectroscopy of Imidazole Ring Functionalized Monolayer on Smooth Gold Electrode

Molecules, 2022
The imidazole ring (Im) of histidine side chains plays a unique role in the function of proteins through covalent bonding with metal ions and hydrogen bonding interactions with adjusted biomolecules and water. At biological interfaces, these interactions
Agnė Zdaniauskienė, Martynas Talaikis, Tatjana Charkova, Rita Sadzevičienė, Linas Labanauskas, Gediminas Niaura   +5 more
doaj   +1 more source

Different Biological Activities of Histidine-Rich Peptides Are Favored by Variations in Their Design

Toxins, 2021
The protein transduction and antimicrobial activities of histidine-rich designer peptides were investigated as a function of their sequence and compared to gene transfection, lentivirus transduction and calcein release activities.
Morane Lointier, Candice Dussouillez, Elise Glattard, Antoine Kichler, Burkhard Bechinger   +4 more
doaj   +1 more source

Biosynthesis of Histidine [PDF]

EcoSal Plus, 2009
The biosynthesis of histidine in Escherichia coli and Salmonella typhimurium has been an important model system for the study of relationships between the flow of intermediates through a biosynthetic pathway and the control of the genes encoding the enzymes that catalyze the steps in a ...
Malcolm E, Winkler, Smirla, Ramos-Montañez   +1 more
openaire   +2 more sources

Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides

Molecules, 2023
Venous thromboembolism is a serious problem because it significantly increases the risk of developing vascular complications in elderly patients with obesity or immobilization, cancer, and many other diseases.
Victor P. Krasnov, Irina A. Nizova, Alexey Yu. Vigorov, Tatyana V. Matveeva, Galina L. Levit, Mikhail I. Kodess, Marina A. Ezhikova, Pavel A. Slepukhin, Dmitry A. Bakulin, Ivan N. Tyurenkov, Valery N. Charushin   +10 more
doaj   +1 more source

Histidine-Rich Defensins from the Solanaceae and Brasicaceae Are Antifungal and Metal Binding Proteins

Journal of Fungi, 2020
Plant defensins are best known for their antifungal activity and contribution to the plant immune system. The defining feature of plant defensins is their three-dimensional structure known as the cysteine stabilized alpha-beta motif. This protein fold is
Mark R. Bleackley, Shaily Vasa, Peta J. Harvey, Thomas M. A. Shafee, Bomai K. Kerenga, Tatiana P. Soares da Costa, David J. Craik, Rohan G. T. Lowe, Marilyn A. Anderson   +8 more
doaj   +1 more source

The level of sialic acids and imidazole compounds in the saliva of patients with lung cancer of different histological types

Сибирский онкологический журнал, 2019
In recent years, the possibility of using known and new tumor markers in primary and differential diagnosis of lung cancer has been actively studied.The purpose of the study was to study the level of sialic acids, the total content of imidazole compounds
L. V. Belskaya, V. K. Kosenok
doaj   +1 more source