Results 41 to 50 of about 308,029 (295)
Biomimetics, 2019 Biology offers a valuable inspiration toward the development of self-healing engineering composites and polymers. In particular, chemical level design principles extracted from proteinaceous biopolymers, especially the mussel byssus, provide inspiration ...
Stefan Zechel +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
All‐Hand‐Drawn Flexible UV–Vis–NIR Photodetectors Based on Histidine‐Doped MoS2 Quantum Dots
Advanced Materials InterfacesPhotodetectors play a vital role in optical communications, sensing, and medical diagnostics by converting light into electrical signals. However, conventional PD fabrication typically requires complex procedures and costly equipment, limiting ...
Meng‐Jer Wu +7 more
doaj +1 more source
The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain [PDF]
, 2009 Michel K-P, Schröder A-K, Zimmermann M, et al. The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain. Archives of Microbiology. 2009;191(6):553-559.The cyanobacterium Synechocystis sp.
Zimmermann, Maike +6 more
core +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Histidine-Specific Peptide Modification via Visible-Light-Promoted C–H Alkylation
, 2019 Histidine (His) carries a unique heteroaromatic imidazole side chain and plays irreplaceable functional roles in peptides and proteins. Existing strategies for site-selective histidine modification predominantly rely on the N-substitution reactions of ...
Jie Zhao (49409) +8 more
core +1 more source
Evolution of substrate specificity in a recipient's enzyme following horizontal gene transfer [PDF]
, 2013 Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about the impact of HGT on the evolution of enzyme function.
Noda-Garcia, Lianet +6 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Saudi Journal of Gastroenterology, 2017 Background/Aim: We investigated the association between blood amino acid concentration changes caused by elemental diet (ED) and their relationship to its therapeutic effect. Patients and Methods: Patients with active Crohn's disease (CD) followed ED for
Masakazu Nakano +5 more
doaj +1 more source
, 2019 Protein–protein interactions that can be controlled by environmental triggers have immense potential in various biological and industrial applications.
Momoko Ueda (7525199) +13 more
core +1 more source