Results 41 to 50 of about 291,783 (305)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Structural Effects on the Reaction of Singlet Oxygen with Tertiary Amines in Aqueous Solution
OxygenPhotosensitized excitation of molecular oxygen generates singlet oxygen, a reactive oxygen species that has been studied in biological systems, synthetic methods and in aquatic ecosystems.
Grace Sliwinski +2 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
ChemistryHigh-temperature cooking processes like frying, baking, smoking, or drying can induce chemical transformations in conventional food ingredients, causing deteriorative modifications.
Vaiyapuri Subbarayan Periasamy +2 more
doaj +1 more source
Histidine Metabolism and Function [PDF]
The Journal of Nutrition, 2020 Histidine is a dietary essential amino acid because it cannot be synthesized in humans. The WHO/FAO requirement for adults for histidine is 10 mg · kg body weight-1 · d-1. Histidine is required for synthesis of proteins. It plays particularly important roles in the active site of enzymes, such as serine proteases (e.g., trypsin) where it is a member of
Margaret E, Brosnan, John T, Brosnan
openaire +2 more sources
Epitope Labeling of Histidine Decarboxylase in Drosophila melanogaster [PDF]
, 2006 Histidine decarboxylase (HDC) plays a critical role in the synthesis of histamine, a central nervous system neurotransmitter used by both vertebrates and invertebrates.
Payne, Stephanie A. N.
core +1 more source
Histidine-Directed Arylation/Alkenylation of Backbone N–H Bonds Mediated by Copper(II) [PDF]
, 2016 Chemical modification of proteins and peptides represents a challenge of reaction design as well as an important biological tool. In contrast to side-chain modification, synthetic methods to alter backbone structure are extremely limited.
Zachary T. Ball (1819597) +3 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl‑1 [PDF]
Several novel and effective cysteine targeting (Cys) covalent drugs are in clinical use. However, the target area containing a druggable Cys residue is limited.
Maurizio Pellecchia (135470) +5 more
core +3 more sources
All‐Hand‐Drawn Flexible UV–Vis–NIR Photodetectors Based on Histidine‐Doped MoS2 Quantum Dots
Advanced Materials InterfacesPhotodetectors play a vital role in optical communications, sensing, and medical diagnostics by converting light into electrical signals. However, conventional PD fabrication typically requires complex procedures and costly equipment, limiting ...
Meng‐Jer Wu +7 more
doaj +1 more source