Results 121 to 130 of about 25,601 (192)

T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation

Advanced Science
T‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in the progression of T‐2 toxin‐stimulated podocyte injury.
Tushuai Li, Wenxue Sun, Shenglong Zhu, Chengsheng He, Tong Chang, Jie Zhang, Yongquan Chen   +6 more
doaj   +1 more source

ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy. [PDF]

, 2019
Background:Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G ...
Beard, Timothy L, Bergese, Sergio D, Berkowitz, Richard D, Brzezinski, Marek, Cochrane, Kristina, Habib, Ashraf S, Hammer, Gregory B, Mace, Sharon E, Minkowitz, Harold S, Pan, Peter H, Wase, Linda   +10 more
core  

Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

Nature Communications
The apelin receptor (APJR) plays a pivotal role in regulating cardiovascular and metabolic health1,2. Understanding the mechanisms of biased agonism at APJR is crucial for drug discovery, as stimulation of the β-arrestin pathway may lead to some adverse ...
Yang Yue, Chanjuan Xu, Lijie Wu, Man Na, Kexin Xu, Xuan Chen, Yuxuan Song, Sichun Weng, Lu Xu, Fei Li, Xi Lin, Arthur Wang, Jianfeng Liu, Fei Xu   +13 more
doaj   +1 more source

GRK phosphorylation drives β-arrestin-independent internalization of chemokine receptor CXCR5. [PDF]

J Biol Chem
Crecelius JM, Zhuo Y, Manz AR, Drube J, Schulz S, Hoffmann C, Marchese A.   +6 more
europepmc   +1 more source

Functional and structural insights into interactions between β-Arrestin 1 and Gαs or Gαi1. [PDF]

Nat Commun
Duan L, Kim H, Suh Y, Ahn D, Kim S, Hyun J, Kwon Y, Seong J, Chung KY.   +8 more
europepmc   +1 more source

Angiotensin receptor conformations stabilized by biased ligands differentially modulate β-arrestin interactions. [PDF]

J Biol Chem
Elgeti M, Belyaeva J, Helabad MB, Staus DP, Wingler LM.   +4 more
europepmc   +1 more source

β-Arrestin 1 Differentially Modulates cAMP and ERK Pathways Downstream of the FSH Receptor. [PDF]

Curr Issues Mol Biol
Park SH, Byambaragchaa M, Yu YR, Lee JW, Kwak MJ, Yoon SB, Kim JS, Kang MH, Min KS.   +8 more
europepmc   +1 more source

β‑Arrestin-Mediated Activation of Chemokine Receptor CCR7 by Human β‑Defensin‑3 Drives Oral Squamous Cell Carcinoma Progression. [PDF]

JACS Au
Kinanti NP, Chang CC, Lai XY, Hsu HJ.
europepmc   +1 more source

Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation. [PDF]

Nat Commun
Shi H, Zhang M, Hu X, Zhang J, Chen T, Wu P, Wang X, Wei S, Choy G, Temitayo Bello S, Chen H, Liu C, Guo Y, Sun H, He J.   +14 more
europepmc   +1 more source

Carfentanil is a β-arrestin-biased agonist at the μ opioid receptor. [PDF]

Br J Pharmacol, 2023
Ramos-Gonzalez N, Groom S, Sutcliffe KJ, Bancroft S, Bailey CP, Sessions RB, Henderson G, Kelly E.   +7 more
europepmc   +1 more source