β-arrestin-1 and β-arrestin-2 Restrain MRGPRX2-Triggered Degranulation and ERK1/2 Activation in Human Skin Mast Cells [PDF]
Frontiers in Allergy, 2022 As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research.
Zhao Wang +12 more
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LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1 [PDF]
Scientific Reports, 2021 Recent evidence suggests that psychedelic drugs can exert beneficial effects on anxiety, depression, and ethanol and nicotine abuse in humans. However, their hallucinogenic side-effects often preclude their clinical use.
Ramona M. Rodriguiz +6 more
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T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation [PDF]
Advanced ScienceT‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in the progression of T‐2 toxin‐stimulated podocyte injury.
Tushuai Li +6 more
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β-Arrestin 1 in Thyrotropin Receptor Signaling in Bone: Studies in Osteoblast-Like Cells [PDF]
Frontiers in Endocrinology, 2020 A direct action of thyrotropin (TSH, thyroid-stimulating hormone) on bone precursors in humans is controversial. Studies in rodent models have provided conflicting findings.
Alisa Boutin +2 more
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Behavioral Characterization of β-Arrestin 1 Knockout Mice in Anxiety-Like and Alcohol Behaviors [PDF]
Frontiers in Behavioral Neuroscience, 2018 β-Arrestin 1 and 2 are highly expressed proteins involved in the desensitization of G protein-coupled receptor signaling which also regulate a variety of intracellular signaling pathways.
Meridith T. Robins +5 more
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β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility [PDF]
Skeletal Muscle, 2018 Background β2-adrenergic receptors (β2ARs) are the target of catecholamines and play fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology.
Jihee Kim +9 more
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Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility [PDF]
eLife, 2018 Luminal fluid reabsorption plays a fundamental role in male fertility. We demonstrated that the ubiquitous GPCR signaling proteins Gq and β-arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGRG2 ...
Dao-Lai Zhang +27 more
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Frontiers in Pharmacology, 2022 The δ-opioid receptor (δOR) has been considered as a therapeutic target in multiple neurological and neuropsychiatric disorders particularly as δOR agonists are deemed safer alternatives relative to the more abuse-liable µ-opioid receptor drugs. Clinical
Arryn T. Blaine +12 more
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Frontiers in Physiology, 2021 An increased vulnerability has been detected after ischemia/reperfusion injury in cardiomyocytes in diabetic patients. Glucagon-like peptide-1 (GLP-1) has been proven to have a notable cardioprotective effect in cardiomyocytes.
Xietian Pan, Chengxiang Li, Haokao Gao
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ClickArr: a novel, high-throughput assay for evaluating β-arrestin isoform recruitment
Frontiers in Pharmacology, 2023 Background: Modern methods for quantifying signaling bias at G protein–coupled receptors (GPCRs) rely on using a single β-arrestin isoform. However, it is increasingly appreciated that the two β-arrestin isoforms have unique roles, requiring the ability ...
Alexander R. French +6 more
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