Results 1 to 10 of about 31,759 (252)

Receptor-Arrestin Interactions: The GPCR Perspective

Biomolecules, 2021
Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three functions: precluding further receptor coupling to G proteins ...
Eugenia V Gurevich, Vsevolod V. Gurevich, Mohammad Seyedabadi   +2 more
exaly   +4 more sources

Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights. [PDF]

Smart Mol
Molecular glues exert diverse core biological functions by inducing or stabilizing protein–protein interactions, extending far beyond the traditional scope of targeted protein degradation. Key breakthroughs include expanded cereblon substrate recognition, sustained G protein‐coupled receptor megacomplex signaling, and the first orthosteric molecular ...
Guan Q, Shi X, Yang Q, Jiang X, Liu X, Zhan P.   +5 more
europepmc   +2 more sources

X‐Arrestin: a new retinal arrestin mapping to the X chromosome [PDF]

FEBS Letters, 1993
We have been using a differential cDNA cloning approach to isolate human retina‐specific and retina‐enriched genes [1]. A 1,314 bp cDNA was isolated by this approach, representing a highly retina‐specific message encoding a 388 amino acid protein showing 58%, 50%, and 49% homology to bovine β‐arrestin, and bovine and human retinal arrestin (S‐antigen),
Murakami, Akira, Yajima, Toshihiro, Sakuma, Hitoshi, McLaren, Margaret J., Inana, George   +4 more
openaire   +4 more sources

β-Arrestin-dependent deactivation of mouse melanopsin.

PLoS ONE, 2014
In mammals, the expression of the unusual visual pigment, melanopsin, is restricted to a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling regulate numerous non-visual functions including sleep, circadian ...
Evan G Cameron, Phyllis R Robinson
doaj   +2 more sources

Beta‐Arrestin‐2 Binds to Nucleolar Organizing Regions With P2X7 Receptor Stimulation and During Cell Division [PDF]

FASEB J
Beta‐Arrestin‐2 but not Beta‐Arrestin‐1 can accumulate in the nucleolus and come in close contact with the Nucleolar Organizing Regions during two distinct processes: P2X7 receptor stimulation (A) and cell division (B). Both seem to be due to loss of nuclear membrane barrier that keeps Beta‐arrestin‐2 out of the nucleus.
Gümüştaş T, Uysal S, Casella I, Uğur Ö, Uğur M.   +4 more
europepmc   +2 more sources

Subtype-dependent arrestin engagement of the metabotropic glutamate receptors [PDF]

Nature Communications
The arrestin-mediated regulation of signaling through the metabotropic glutamate receptors (mGlus) is fundamental mechanism modulating excitatory transmission and synaptic plasticity.
Shuling Lin, Chenhui Zhang, Jiaxin Wei, Shanshan Li, Jie Yu, Jingyi Xu, Kun Chen, Ye Feng, Ziyu Wang, Xiaojing Chu, Cuiying Yi, Limin Ma, Shuo Han, Wenqing Shui, Qiang Zhao, Beili Wu   +15 more
doaj   +2 more sources

β-arrestin-1 and β-arrestin-2 Restrain MRGPRX2-Triggered Degranulation and ERK1/2 Activation in Human Skin Mast Cells

Frontiers in Allergy, 2022
As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research.
Zhao Wang, Zhao Wang, Zhao Wang, Zhuoran Li, Zhuoran Li, Gürkan Bal, Gürkan Bal, Kristin Franke, Kristin Franke, Torsten Zuberbier, Torsten Zuberbier, Magda Babina, Magda Babina   +12 more
doaj   +1 more source

ClickArr: a novel, high-throughput assay for evaluating β-arrestin isoform recruitment

Frontiers in Pharmacology, 2023
Background: Modern methods for quantifying signaling bias at G protein–coupled receptors (GPCRs) rely on using a single β-arrestin isoform. However, it is increasingly appreciated that the two β-arrestin isoforms have unique roles, requiring the ability ...
Alexander R. French, Alexander R. French, Yazan J. Meqbil, Yazan J. Meqbil, Richard M. van Rijn, Richard M. van Rijn, Richard M. van Rijn   +6 more
doaj   +1 more source

The arrestin superfamily: cone arrestins are a fourth family [PDF]

FEBS Letters, 1995
Arrestins constitute a superfamily of regulatory proteins that down‐regulate phosphorylated G‐protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. The potential role of arrestin in color visual processes led us to identify a cDNA encoding a cone‐like arrestin in Xenopus laevis, the principle amphibian biological ...
Craft, Cheryl M., Whitmore, Donald H.
openaire   +2 more sources

Untersuchungen zur Phosphorylierung von Rhodopsin und deren Einfluss auf die Arrestin-Rhodopsin-Bindung [PDF]

, 2021
Die phosphorylierungsabhängige Bindung von Arrestin an G-Protein-gekoppelte Rezeptoren (GPCRs) ist ein weit verbreiteter Mechanismus, um aktive Rezeptoren zu inhibieren. Für die Bindung von Arrestin an lichtaktiviertes, phosphoryliertes Rhodopsin (pRho),
Vogt, Vivien 1989-, Vogt, Vivien
core   +1 more source