Results 31 to 40 of about 31,759 (252)
Frontiers in Pharmacology, 2019 Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor–arrestin interactions are relatively well understood and considered responsible for specific therapeutic or adverse ...
Mikkel Søes Ibsen +9 more
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DEER Analysis of GPCR Conformational Heterogeneity
Biomolecules, 2021 G protein-coupled receptors (GPCRs) represent a large class of transmembrane helical proteins which are involved in numerous physiological signaling pathways and therefore represent crucial pharmacological targets.
Matthias Elgeti, Wayne L. Hubbell
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Isoflurane induces Art2‐Rsp5‐dependent endocytosis of Bap2 in yeast
FEBS Open Bio, 2021 Although general anesthesia is indispensable during modern surgical procedures, the mechanism by which inhalation anesthetics act on the synaptic membrane at the molecular and cellular level is largely unknown.
Fumi Kozu +5 more
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Frontiers in Cellular and Infection Microbiology, 2022 Arrestins are a family of scaffold proteins that play a crucial role in regulating numerous cellular processes, such as GPCR signaling. The Arthrobotrys oligospora arrestin family contains 12 members, which have highly conserved N-terminal and C-terminal
Liang Zhou +17 more
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Pharmacological parameters obtained in β-arrestin-2 recruitment assays.
, 2020 Pharmacological parameters obtained in β-arrestin-2 recruitment assays.
Tony Ngo (5072279) +6 more
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Functional characterization of an arrestin gene on insecticide resistance of
Parasites & Vectors, 2012 Background Continuous and excessive application of insecticides has resulted in the rapid development of insecticide resistance in several mosquito species, including Culex pipiens pallens.
Sun Yan +13 more
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β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate [PDF]
, 2020 The treatment of pediatric heart failure is a long-standing unmet medical need. Angiotensin II supports mammalian perinatal circulation by activating cardiac L-type Ca2+ channels through angiotensin type 1 receptor (AT1R) and β-arrestin.
Kawagishi, Hiroyuki +9 more
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, 2021 Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that inflicts damage to the joints of the hands and wrist. The aim of this study was to investigate the protective effect of β-Arrestin-2 (βArr2) on RA in vivo and in vitro.
Jiwei Cheng (8319618) +3 more
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, 2020 (A) Melanopsin (pink) in complex with β-arrestin 1 (green). Proximal C-terminus phosphorylation sites are indicated in dark red. (B) Melanopsin (pink) in complex with β-arrestin 1, which has surface charge indicated by red, blue, or white.
Elelbin A. Ortiz (8655285) +4 more
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Inferring the lifetime of endosomal protein complexes by fluorescence recovery after photobleaching [PDF]
, 2008 Cellular signal transduction is dynamic, with signaling proteins continually associating and dissociating into and from protein complexes. Here we present a fluorescence recovery after photobleaching technique to determine the lifetime of protein ...
Gousseva, Veronika +5 more
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